LAMA5_MOUSE - dbPTM
LAMA5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAMA5_MOUSE
UniProt AC Q61001
Protein Name Laminin subunit alpha-5
Gene Name Lama5
Organism Mus musculus (Mouse).
Sequence Length 3718
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
Protein Description Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae..
Protein Sequence MAKRGGQLCAGSAPGALGPRSPAPRPLLLLLAGLALVGEARTPGGDGFSLHPPYFNLAEGARITASATCGEEAPTRSVSRPTEDLYCKLVGGPVAGGDPNQTIQGQYCDICTAANSNKAHPVSNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSTDFGHTYQPWQFFASSKRDCLERFGPRTLERITQDDDVICTTEYSRIVPLENGEIVVSLVNGRPGALNFSYSPLLRDFTKATNIRLRFLRTNTLLGHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADVCDAKDPLDPFRLQCACQHNTCGGSCDRCCPGFNQQPWKPATTDSANECQSCNCHGHAYDCYYDPEVDRRNASQNQDNVYQGGGVCLDCQHHTTGINCERCLPGFFRAPDQPLDSPHVCRPCDCESDFTDGTCEDLTGRCYCRPNFTGELCAACAEGYTDFPHCYPLPSFPHNDTREQVLPAGQIVNCDCNAAGTQGNACRKDPRLGRCVCKPNFRGAHCELCAPGFHGPSCHPCQCSSPGVANSLCDPESGQCMCRTGFEGDRCDHCALGYFHFPLCQLCGCSPAGTLPEGCDEAGRCQCRPGFDGPHCDRCLPGYHGYPDCHACACDPRGALDQQCGVGGLCHCRPGYTGATCQECSPGFYGFPSCIPCHCSADGSLHTTCDPTTGQCRCRPRVTGLHCDMCVPGAYNFPYCEAGSCHPAGLAPANPALPETQAPCMCRAHVEGPSCDRCKPGYWGLSASNPEGCTRCSCDPRGTLGGVTECQGNGQCFCKAHVCGKTCAACKDGFFGLDYADYFGCRSCRCDVGGALGQGCEPKTGACRCRPNTQGPTCSEPAKDHYLPDLHHMRLELEEAATPEGHAVRFGFNPLEFENFSWRGYAHMMAIQPRIVARLNVTSPDLFRLVFRYVNRGSTSVNGQISVREEGKLSSCTNCTEQSQPVAFPPSTEPAFVTVPQRGFGEPFVLNPGIWALLVEAEGVLLDYVVLLPSTYYEAALLQHRVTEACTYRPSALHSTENCLVYAHLPLDGFPSAAGTEALCRHDNSLPRPCPTEQLSPSHPPLATCFGSDVDIQLEMAVPQPGQYVLVVEYVGEDSHQEMGVAVHTPQRAPQQGVLNLHPCPYSSLCRSPARDTQHHLAIFYLDSEASIRLTAEQAHFFLHSVTLVPVEEFSTEFVEPRVFCVSSHGTFNPSSAACLASRFPKPPQPIILKDCQVLPLPPDLPLTQSQELSPGAPPEGPQPRPPTAVDPNAEPTLLRHPQGTVVFTTQVPTLGRYAFLLHGYQPVHPSFPVEVLINGGRIWQGHANASFCPHGYGCRTLVLCEGQTMLDVTDNELTVTVRVPEGRWLWLDYVLIVPEDAYSSSYLQEEPLDKSYDFISHCATQGYHISPSSSSPFCRNAATSLSLFYNNGALPCGCHEVGAVSPTCEPFGGQCPCRGHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTVPPDCLVCQPQSFGCHPLVGCEECNCSGPGVQELTDPTCDMDSGQCRCRPNVAGRRCDTCAPGFYGYPSCRPCDCHEAGTMASVCDPLTGQCHCKENVQGSRCDQCRVGTFSLDAANPKGCTRCFCFGATERCGNSNLARHEFVDMEGWVLLSSDRQVVPHEHRPEIELLHADLRSVADTFSELYWQAPPSYLGDRVSSYGGTLHYELHSETQRGDIFIPYESRPDVVLQGNQMSIAFLELAYPPPGQVHRGQLQLVEGNFRHLETHNPVSREELMMVLAGLEQLQIRALFSQTSSSVSLRRVVLEVASEAGRGPPASNVELCMCPANYRGDSCQECAPGYYRDTKGLFLGRCVPCQCHGHSDRCLPGSGICVGCQHNTEGDQCERCRPGFVSSDPSNPASPCVSCPCPLAVPSNNFADGCVLRNGRTQCLCRPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNMIFSDCDPLTGACRGCLRHTTGPHCERCAPGFYGNALLPGNCTRCDCSPCGTETCDPQSGRCLCKAGVTGQRCDRCLEGYFGFEQCQGCRPCACGPAAKGSECHPQSGQCHCQPGTTGPQCLECAPGYWGLPEKGCRRCQCPRGHCDPHTGHCTCPPGLSGERCDTCSQQHQVPVPGKPGGHGIHCEVCDHCVVLLLDDLERAGALLPAIREQLQGINASSAAWARLHRLNASIADLQSKLRSPPGPRYQAAQQLQTLEQQSISLQQDTERLGSQATGVQGQAGQLLDTTESTLGRAQKLLESVRAVGRALNELASRMGQGSPGDALVPSGEQLRWALAEVERLLWDMRTRDLGAQGAVAEAELAEAQRLMARVQEQLTSFWEENQSLATHIRDQLAQYESGLMDLREALNQAVNTTREAEELNSRNQERLKEALQWKQELSQDNATLKATLQAASLILGHVSELLQGIDQAKEDLEHLAASLDGAWTPLLKRMQAFSPASSKVDLVEAAEAHAQKLNQLAINLSGIILGINQDRFIQRAVEASNAYSSILQAVQAAEDAAGQALRQASRTWEMVVQRGLAAGARQLLANSSALEETILGHQGRLGLAQGRLQAAGIQLHNVWARKNQLAAQIQEAQAMLAMDTSETSEKIAHAKAVAAEALSTATHVQSQLQGMQKNVERWQSQLGGLQGQDLSQVERDASSSVSTLEKTLPQLLAKLSRLENRGVHNASLALSANIGRVRKLIAQARSAASKVKVSMKFNGRSGVRLRTPRDLADLAAYTALKFHIQSPVPAPEPGKNTGDHFVLYMGSRQATGDYMGVSLRNQKVHWVYRLGKAGPTTLSIDENIGEQFAAVSIDRTLQFGHMSVTVEKQMVHEIKGDTVAPGSEGLLNLHPDDFVFYVGGYPSNFTPPEPLRFPGYLGCIEMETLNEEVVSLYNFEQTFMLDTAVDKPCARSKATGDPWLTDGSYLDGSGFARISFEKQFSNTKRFDQELRLVSYNGIIFFLKQESQFLCLAVQEGTLVLFYDFGSGLKKADPLQPPQALTAASKAIQVFLLAGNRKRVLVRVERATVFSVDQDNMLEMADAYYLGGVPPEQLPLSLRQLFPSGGSVRGCIKGIKALGKYVDLKRLNTTGISFGCTADLLVGRTMTFHGHGFLPLALPDVAPITEVVYSGFGFRGTQDNNLLYYRTSPDGPYQVSLREGHVTLRFMNQEVETQRVFADGAPHYVAFYSNVTGVWLYVDDQLQLVKSHERTTPMLQLQPEEPSRLLLGGLPVSGTFHNFSGCISNVFVQRLRGPQRVFDLHQNMGSVNVSVGCTPAQLIETSRATAQKVSRRSRQPSQDLACTTPWLPGTIQDAYQFGGPLPSYLQFVGISPSHRNRLHLSMLVRPHAASQGLLLSTAPMSGRSPSLVLFLNHGHFVAQTEGPGPRLQVQSRQHSRAGQWHRVSVRWGMQQIQLVVDGSQTWSQKALHHRVPRAERPQPYTLSVGGLPASSYSSKLPVSVGFSGCLKKLQLDKRPLRTPTQMVGVTPCVSGPLEDGLFFPGSEGVVTLELPKAKMPYVSLELEMRPLAAAGLIFHLGQALATPYMQLKVLTEQVLLQANDGAGEFSTWVTYPKLCDGRWHRVAVIMGRDTLRLEVDTQSNHTTGRLPESLAGSPALLHLGSLPKSSTARPELPAYRGCLRKLLINGAPVNVTASVQIQGAVGMRGCPSGTLALSKQGKALTQRQAKPSVSPLLWH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationGGQLCAGSAPGALGP
CCCCCCCCCCCCCCC		16.86-
21PhosphorylationPGALGPRSPAPRPLL
CCCCCCCCCCCHHHH		28.66-
100N-linked_GlycosylationPVAGGDPNQTIQGQY
CCCCCCCCCCCCCEE		57.26-
102O-linked_GlycosylationAGGDPNQTIQGQYCD
CCCCCCCCCCCEECC		23.1630059200
148N-linked_GlycosylationGLEYNEVNVTLDLGQ
CCCCCEEEEEEEHHH		18.19-
248N-linked_GlycosylationNGRPGALNFSYSPLL
CCCCCCCCCCCHHHH		24.2319349973
260AcetylationPLLRDFTKATNIRLR
HHHCCHHHHHCCHHH		53.8921728379
271PhosphorylationIRLRFLRTNTLLGHL
CHHHHHHHCHHHHHH		34.4028576409
273PhosphorylationLRFLRTNTLLGHLMG
HHHHHHCHHHHHHHH		23.8128576409
383N-linked_GlycosylationDPEVDRRNASQNQDN
CHHHCCCCCCCCCCC		44.85-
457N-linked_GlycosylationGRCYCRPNFTGELCA
CCEEECCCCCHHHHH		27.97-
485N-linked_GlycosylationPLPSFPHNDTREQVL
ECCCCCCCCCCCCCC		53.22-
905N-linked_GlycosylationFNPLEFENFSWRGYA
CCCCEECCCCCCCCC		41.39-
926N-linked_GlycosylationPRIVARLNVTSPDLF
CEEEEECCCCCHHHH		29.4819349973
952PhosphorylationTSVNGQISVREEGKL
CCCCCEEEEEECCEE		13.7723882026
964N-linked_GlycosylationGKLSSCTNCTEQSQP
CEECCCCCCCCCCCC		34.73-
1335N-linked_GlycosylationRIWQGHANASFCPHG
EEEECCCCCCCCCCC		30.37-
1534N-linked_GlycosylationLVGCEECNCSGPGVQ
CCCCCCCCCCCCCCC		26.69-
1806PhosphorylationLFSQTSSSVSLRRVV
HHCCCCCCHHHHHHH		18.5923737553
1808PhosphorylationSQTSSSVSLRRVVLE
CCCCCCHHHHHHHHH		20.3627555448
2021N-linked_GlycosylationGNALLPGNCTRCDCS
CCCCCCCCCCCCCCC		23.27-
2140O-linked_GlycosylationCTCPPGLSGERCDTC
CCCCCCCCCCCCCCC		44.5230059200
2198N-linked_GlycosylationREQLQGINASSAAWA
HHHHCCCCHHHHHHH		40.3619349973
2211N-linked_GlycosylationWARLHRLNASIADLQ
HHHHHHHCCHHHHHH		31.4319349973
2365N-linked_GlycosylationLTSFWEENQSLATHI
HHHHHHHHHHHHHHH		25.81-
2381PhosphorylationDQLAQYESGLMDLRE
HHHHHHHHCHHHHHH		32.09-
2395N-linked_GlycosylationEALNQAVNTTREAEE
HHHHHHHHHHHHHHH		38.4519349973
2425N-linked_GlycosylationKQELSQDNATLKATL
HHHHCCCCHHHHHHH		27.4719349973
2443PhosphorylationSLILGHVSELLQGID
HHHHHHHHHHHHCHH		19.49-
2503N-linked_GlycosylationKLNQLAINLSGIILG
HHHHHHHHHHHHHEE		23.65-
2570N-linked_GlycosylationGARQLLANSSALEET
HHHHHHHCCHHHHHH		36.14-
2691PhosphorylationSVSTLEKTLPQLLAK
CHHHHHHHHHHHHHH		34.0022871156
2700PhosphorylationPQLLAKLSRLENRGV
HHHHHHHHHHHHCCC		33.8322871156
2709N-linked_GlycosylationLENRGVHNASLALSA
HHHCCCCCHHHHHHC		28.90-
2715PhosphorylationHNASLALSANIGRVR
CCHHHHHHCCHHHHH		17.4224719451
3111N-linked_GlycosylationYVDLKRLNTTGISFG
EEEHHCCCCCCCCCC		39.36-
3213N-linked_GlycosylationHYVAFYSNVTGVWLY
CEEEEEECCEEEEEE		24.80-
3261N-linked_GlycosylationPVSGTFHNFSGCISN
CCCCEEECCCCHHHH		28.70-
3291N-linked_GlycosylationHQNMGSVNVSVGCTP
HCCCCCEEEECCCCH		23.26-
3540PhosphorylationLPKAKMPYVSLELEM
CCCCCCCEEEEEEEC		10.12-
3623N-linked_GlycosylationLEVDTQSNHTTGRLP
EEEECCCCCCCCCCC		27.0619349973
3673N-linked_GlycosylationLINGAPVNVTASVQI
HHCCCCCEEEEEEEE		25.10-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAMA5_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAMA5_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAMA5_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LAMA5_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAMA5_MOUSE

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-248; ASN-926; ASN-2198;ASN-2211; ASN-2395; ASN-2425 AND ASN-3623, AND MASS SPECTROMETRY.

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