CPSF1_MOUSE - dbPTM
CPSF1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CPSF1_MOUSE
UniProt AC Q9EPU4
Protein Name Cleavage and polyadenylation specificity factor subunit 1
Gene Name Cpsf1
Organism Mus musculus (Mouse).
Sequence Length 1441
Subcellular Localization Nucleus, nucleoplasm.
Protein Description Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity)..
Protein Sequence MYAVYKQAHPPTGLEFTMYCNFFNNSERNLVVAGTSQLYVYRLNRDAEALTKNDGSTEGKAHREKLELVASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLIYGTRLVVLPFRRESLAEEHEGLMGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIGGVVIFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQAAFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSLLLKYTEKLQEPPASSVREAADKEEPPSKKKRVEPAVGWTGGKTVPQDEVDEIEVYGSEAQSGTQLATYSFEVCDSMLNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGYGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEETPKAESTEQEPSAPKAEEDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHKPPLHHQSKVIALCLYRDVSGMFTTESRLGGARDELGGRSGSEAEGLGSETSPTVDDEEEMLYGDSSALFSPSKEEARRSSQPPADRDPAPFKADPTHWCLLVRENGTMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEVRKEEATRQGELPLVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGCSTEEGSGGRGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMGIDGPIDSFAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCTRIPRMTGEEKEFEAIERDDRYIHPQQEAFSIQLISPVSWEAIPNARIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAHF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
381PhosphorylationMVTMEPGYLFLGSRL
CCCCCCCEEEECCHH		12.6628576409
399UbiquitinationLLLKYTEKLQEPPAS
HHHHHHHHHCCCCCH		47.9022790023
406PhosphorylationKLQEPPASSVREAAD
HHCCCCCHHHHHHHC		34.8330482847
407PhosphorylationLQEPPASSVREAADK
HCCCCCHHHHHHHCC		27.5725338131
559PhosphorylationESTEQEPSAPKAEED
CCCCCCCCCCCCCCC		57.3524719451
581PhosphorylationILSREDSTMILQTGQ
EEECCCCEEEEECCC		22.1322802335
586PhosphorylationDSTMILQTGQEIMEL
CCEEEEECCCEEEEE		37.0722802335
595PhosphorylationQEIMELDTSGFATQG
CEEEEECCCCCCCCC		43.2922802335
596PhosphorylationEIMELDTSGFATQGP
EEEEECCCCCCCCCC		31.4222802335
600PhosphorylationLDTSGFATQGPTVFA
ECCCCCCCCCCEEEE		31.6222802335
604PhosphorylationGFATQGPTVFAGNIG
CCCCCCCEEEECEEC		34.7722802335
615PhosphorylationGNIGDNRYIVQVSPL
CEECCCEEEEEECHH		16.2322802335
620PhosphorylationNRYIVQVSPLGIRLL
CEEEEEECHHHHHHC		9.4122802335
723PhosphorylationRDELGGRSGSEAEGL
CCCCCCCCCCCCCCC		50.3625619855
725PhosphorylationELGGRSGSEAEGLGS
CCCCCCCCCCCCCCC		34.5725619855
732PhosphorylationSEAEGLGSETSPTVD
CCCCCCCCCCCCCCC		42.6225619855
734PhosphorylationAEGLGSETSPTVDDE
CCCCCCCCCCCCCCH		41.5225619855
735PhosphorylationEGLGSETSPTVDDEE
CCCCCCCCCCCCCHH		17.9625619855
737PhosphorylationLGSETSPTVDDEEEM
CCCCCCCCCCCHHHH		36.0125619855
746PhosphorylationDDEEEMLYGDSSALF
CCHHHHHHCCCCCCC		19.9925619855
749PhosphorylationEEMLYGDSSALFSPS
HHHHHCCCCCCCCCC		17.1021082442
750PhosphorylationEMLYGDSSALFSPSK
HHHHCCCCCCCCCCH		33.4625619855
754PhosphorylationGDSSALFSPSKEEAR
CCCCCCCCCCHHHHH		29.1621082442
756PhosphorylationSSALFSPSKEEARRS
CCCCCCCCHHHHHHC		52.0525619855
763PhosphorylationSKEEARRSSQPPADR
CHHHHHHCCCCCCCC		27.9825159016
764PhosphorylationKEEARRSSQPPADRD
HHHHHHCCCCCCCCC		44.9126824392
1032PhosphorylationYHVESKVYAVATSTN
EEEECCEEEEEECCC		10.0920139300
1036PhosphorylationSKVYAVATSTNTPCT
CCEEEEEECCCCCCC		29.5020139300
1037PhosphorylationKVYAVATSTNTPCTR
CEEEEEECCCCCCCC		15.2120139300
1038PhosphorylationVYAVATSTNTPCTRI
EEEEEECCCCCCCCC		38.4620139300
1242PhosphorylationQEESKTLSLVSRDAK
HHHCCCEEEECCCCC		31.7726370283
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CPSF1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CPSF1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CPSF1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CPSF1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CPSF1_MOUSE

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Related Literatures of Post-Translational Modification

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