KI20A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI20A_MOUSE
• UniProt AC: P97329
• Protein Name: Kinesin-like protein KIF20A
• Gene Name: Kif20a
• Organism: Mus musculus (Mouse).
• Sequence Length: 887
• Subcellular Localization: Golgi apparatus. Cytoplasm, cytoskeleton, spindle .
• Protein Description: Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility..
• Protein Sequence: MSHRILSPPAGLLSDEDVVDSPILESTAADLRSVVRKDLLSDCSVISASLEDKQALLEDTSEKVKVYLRIRPFLTSELDRQEDQGCVCIENTETLVLQAPKDSFALKSNERGVGQATHKFTFSQIFGPEVGQVAFFNLTMKEMVKDVLKGQNWLIYTYGVTNSGKTYTIQGTSKDAGILPQSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLIGGLQEEELSTSVKKRVHTESRIGASNSFDSGVAGLSSTSQFTSSSQLDETSQLWAQPDTVPVSVPADIRFSVWISFFEIYNELLYDLLEPPSHQHKRQTLRLCEDQNGNPYVKDLNWIHVRDVEEAWKLLKVGRKNQSFASTHMNQQSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKHQKSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLIPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHAAKFSALASQLVHAPPVHLGIPSLHSFIKKHSPQVGPGLEKEDKADSDLEDSPEDEADVSVYGKEELLQVVEAMKALLLKERQEKLQLEIQLREEICNEMVEQMQQREQWCSERLDNQKELMEELYEEKLKILKESLTTFYQEQIQERDEKIEELETLLQEAKQQPAAQQSGGLSLLRRSQRLAASASTQQFQEVKAELEQCKTELSSTTAELHKYQQVLKPPPPAKPFTIDVDKKLEEGQKNIRLLRTELQKLGQSLQSAERACCHSTGAGKLRQALTNCDDILIKQNQTLAELQNNMVLVKLDLQKKAACIAEQYHTVLKLQGQASAKKRLGANQENQQPNHQPPGKKPFLRNLLPRTPTCQSSTDSSPYARILRSRHSPLLKSPFGKKY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSHRILSPP ------CCCCCCCCC	22.82	-
2	Phosphorylation	------MSHRILSPP ------CCCCCCCCC	22.82	26745281
7	Phosphorylation	-MSHRILSPPAGLLS -CCCCCCCCCCCCCC	26.85	26824392
14	Phosphorylation	SPPAGLLSDEDVVDS CCCCCCCCCHHHCCC	43.95	21149613
21	Phosphorylation	SDEDVVDSPILESTA CCHHHCCCHHHHCHH	11.39	24759943
44	Phosphorylation	KDLLSDCSVISASLE HHHHCCCEEEECCHH	27.72	28066266
47	Phosphorylation	LSDCSVISASLEDKQ HCCCEEEECCHHHHH	15.06	28066266
424	Ubiquitination	QKSGERLKEAGNINT CCCCHHHHHHCCCCH	52.30	-
527	Phosphorylation	HSFIKKHSPQVGPGL HHHHHHHCCCCCCCC	26.38	26824392
542	Phosphorylation	EKEDKADSDLEDSPE CHHCCCCCCCCCCCC	49.29	27087446
547	Phosphorylation	ADSDLEDSPEDEADV CCCCCCCCCCCCCCC	22.33	25619855
666	Phosphorylation	QQPAAQQSGGLSLLR HCHHHHHHCCHHHHH	23.81	28066266
670	Phosphorylation	AQQSGGLSLLRRSQR HHHHCCHHHHHHHHH	28.74	28066266
675	Phosphorylation	GLSLLRRSQRLAASA CHHHHHHHHHHHHCC	17.14	29514104
683	Phosphorylation	QRLAASASTQQFQEV HHHHHCCCHHHHHHH	25.01	27841257
755	Phosphorylation	KLGQSLQSAERACCH HHHHHHHHHHHHHHH	37.07	22067460
823	Phosphorylation	LKLQGQASAKKRLGA HHHHCCCHHHHHHCC	32.50	26824392
855	Phosphorylation	LRNLLPRTPTCQSST HHHCCCCCCCCCCCC	22.47	25263469
857	Phosphorylation	NLLPRTPTCQSSTDS HCCCCCCCCCCCCCC	23.67	25266776
860	Phosphorylation	PRTPTCQSSTDSSPY CCCCCCCCCCCCCHH	37.03	23984901
861	Phosphorylation	RTPTCQSSTDSSPYA CCCCCCCCCCCCHHH	15.45	23984901
862	Phosphorylation	TPTCQSSTDSSPYAR CCCCCCCCCCCHHHH	45.18	23984901
864	Phosphorylation	TCQSSTDSSPYARIL CCCCCCCCCHHHHHH	33.05	25266776
865	Phosphorylation	CQSSTDSSPYARILR CCCCCCCCHHHHHHH	25.41	25263469
867	Phosphorylation	SSTDSSPYARILRSR CCCCCCHHHHHHHHC	15.51	26643407
873	Phosphorylation	PYARILRSRHSPLLK HHHHHHHHCCCCHHC	30.79	25159016
876	Phosphorylation	RILRSRHSPLLKSPF HHHHHCCCCHHCCCC	19.01	27149854
881	Phosphorylation	RHSPLLKSPFGKKY- CCCCHHCCCCCCCC-	25.98	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
527	S	Phosphorylation	Kinase	PLK1	Q07832	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
527	S	Phosphorylation	Phosphorylated by PLK1 at Ser-527 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI20A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KI20A_HUMAN	KIF20A	physical	20360068
PSMD3_HUMAN	PSMD3	physical	26496610
TRIPC_HUMAN	TRIP12	physical	26496610
LCOR_HUMAN	C10orf12	physical	26496610
CAR10_HUMAN	CARD10	physical	26496610
NDUAD_HUMAN	NDUFA13	physical	26496610
RSF1_HUMAN	RSF1	physical	26496610
TNC18_HUMAN	TNRC18	physical	26496610
PWP2A_HUMAN	PWWP2A	physical	26496610
SOGA1_HUMAN	SOGA1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.