dbPTM

TRIPC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRIPC_HUMAN
UniProt AC	Q14669
Protein Name	E3 ubiquitin-protein ligase TRIP12
Gene Name	TRIP12
Organism	Homo sapiens (Human).
Sequence Length	1992
Subcellular Localization	Nucleus, nucleoplasm .
Protein Description	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes..
Protein Sequence	MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQQLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPESNQEAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSVSSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSNRPNNNP ------CCCCCCCCC	53.50	21406692
12	Phosphorylation	PNNNPGGSLRRSQRN CCCCCCCCCCHHHCC	25.31	23401153
34	Phosphorylation	DDSIGGRSCSSSSAV CCCCCCCCCCCCCCE	22.94	21712546
36	Phosphorylation	SIGGRSCSSSSAVIV CCCCCCCCCCCCEEE	34.20	24719451
38	Phosphorylation	GGRSCSSSSAVIVPQ CCCCCCCCCCEEECC	13.16	28555341
44 (in isoform 3)	Phosphorylation	-	32.65	30266825
45 (in isoform 3)	Phosphorylation	-	43.02	30266825
49 (in isoform 3)	Phosphorylation	-	31.18	30266825
52 (in isoform 3)	Phosphorylation	-	30.91	-
54	Phosphorylation	EDPDRANTSERQKTG CCCCCCCCCHHHHCC	30.86	28555341
54 (in isoform 3)	Phosphorylation	-	30.86	-
75	Phosphorylation	NSRGVKRSASPDYNR CCCCCCCCCCCCCCC	27.64	30266825
77	Phosphorylation	RGVKRSASPDYNRTN CCCCCCCCCCCCCCC	21.39	29255136
80	Phosphorylation	KRSASPDYNRTNSPS CCCCCCCCCCCCCCC	15.21	30266825
83	Phosphorylation	ASPDYNRTNSPSSAK CCCCCCCCCCCCCCC	36.09	25159151
85	Phosphorylation	PDYNRTNSPSSAKKP CCCCCCCCCCCCCCC	26.08	25159151
87	Phosphorylation	YNRTNSPSSAKKPKA CCCCCCCCCCCCCCC	42.63	22617229
88	Phosphorylation	NRTNSPSSAKKPKAL CCCCCCCCCCCCCCC	47.71	21955146
90 (in isoform 4)	Phosphorylation	-	72.12	18669648
98	Phosphorylation	KPKALQHTESPSETN CCCCCCCCCCCCCCC	25.79	29255136
100	Phosphorylation	KALQHTESPSETNKP CCCCCCCCCCCCCCC	34.58	23401153
102	Phosphorylation	LQHTESPSETNKPHS CCCCCCCCCCCCCCC	67.35	30266825
104	Phosphorylation	HTESPSETNKPHSKS CCCCCCCCCCCCCHH	53.53	29255136
109	Phosphorylation	SETNKPHSKSKKRHL CCCCCCCCHHHHHHC	47.34	25159151
111	Phosphorylation	TNKPHSKSKKRHLDQ CCCCCCHHHHHHCCH	46.56	26434776
123	Methylation	LDQEQQLKSAQSPST CCHHHHHHHCCCCCC	39.13	115979483
127	Phosphorylation	QQLKSAQSPSTSKAH HHHHHCCCCCCCCHH	22.12	24719451
129	Phosphorylation	LKSAQSPSTSKAHTR HHHCCCCCCCCHHHH	51.03	28176443
130	Phosphorylation	KSAQSPSTSKAHTRK HHCCCCCCCCHHHHC	37.32	28985074
148	Acetylation	TGGSRSQKRKRTESS CCCCHHHHCCCCCCC	62.22	19822159
152	Phosphorylation	RSQKRKRTESSCVKS HHHHCCCCCCCCCCC	43.16	-
155	Phosphorylation	KRKRTESSCVKSGSG HCCCCCCCCCCCCCC	19.39	30576142
159	Phosphorylation	TESSCVKSGSGSEST CCCCCCCCCCCCCCC	20.14	25850435
161	Phosphorylation	SSCVKSGSGSESTGA CCCCCCCCCCCCCCC	46.35	29255136
163	Phosphorylation	CVKSGSGSESTGAEE CCCCCCCCCCCCCCH	30.03	25850435
165	Phosphorylation	KSGSGSESTGAEERS CCCCCCCCCCCCHHC	33.56	25056879
166	Phosphorylation	SGSGSESTGAEERSA CCCCCCCCCCCHHCC	36.04	26074081
181	Acetylation	KPTKLASKSATSAKA CCCCHHCCCCCCCCC	38.20	25953088
192	Phosphorylation	SAKAGCSTITDSSSA CCCCCCCCCCCCCCC	31.79	-
194	Phosphorylation	KAGCSTITDSSSAAS CCCCCCCCCCCCCCC	29.89	-
214	Phosphorylation	SAVASASSTVPPGAR CCHHHCCCCCCCCCC	32.89	24260401
223	Methylation	VPPGARVKQGKDQNK CCCCCCCCCCCCCHH	48.02	116252675
234	Phosphorylation	DQNKARRSRSASSPS CCHHHHHHHCCCCCC	25.65	23403867
236	Phosphorylation	NKARRSRSASSPSPR HHHHHHHCCCCCCCC	33.48	28258704
238	Phosphorylation	ARRSRSASSPSPRRS HHHHHCCCCCCCCCC	43.99	23403867
239	Phosphorylation	RRSRSASSPSPRRSS HHHHCCCCCCCCCCH	29.16	28176443
241	Phosphorylation	SRSASSPSPRRSSRE HHCCCCCCCCCCHHH	32.74	28176443
245	Phosphorylation	SSPSPRRSSREKEQS CCCCCCCCHHHHHHH	34.72	26074081
246	Phosphorylation	SPSPRRSSREKEQSK CCCCCCCHHHHHHHC	42.52	26074081
259	Acetylation	SKTGGSSKFDWAARF HCCCCCCCCCHHHHC	49.38	25953088
259	Ubiquitination	SKTGGSSKFDWAARF HCCCCCCCCCHHHHC	49.38	-
267	Phosphorylation	FDWAARFSPKVSLPK CCHHHHCCCCCCCCC	20.47	25159151
271	Phosphorylation	ARFSPKVSLPKTKLS HHCCCCCCCCCCCCC	45.11	30576142
276	Acetylation	KVSLPKTKLSLPGSS CCCCCCCCCCCCCCC	42.05	25953088
276	Ubiquitination	KVSLPKTKLSLPGSS CCCCCCCCCCCCCCC	42.05	-
278	Phosphorylation	SLPKTKLSLPGSSKS CCCCCCCCCCCCCCC	33.79	25159151
282	Phosphorylation	TKLSLPGSSKSETSK CCCCCCCCCCCCCCC	32.43	20068231
283	Phosphorylation	KLSLPGSSKSETSKP CCCCCCCCCCCCCCC	46.22	20068231
285	Phosphorylation	SLPGSSKSETSKPGP CCCCCCCCCCCCCCC	48.32	20068230
287	Phosphorylation	PGSSKSETSKPGPSG CCCCCCCCCCCCCCH	49.49	-
288	Phosphorylation	GSSKSETSKPGPSGL CCCCCCCCCCCCCHH	32.57	-
289	Ubiquitination	SSKSETSKPGPSGLQ CCCCCCCCCCCCHHH	62.50	-
293	Phosphorylation	ETSKPGPSGLQAKLA CCCCCCCCHHHHHHH	59.04	24114839
298	Acetylation	GPSGLQAKLASLRKS CCCHHHHHHHHHHHH	31.46	25953088
298	Ubiquitination	GPSGLQAKLASLRKS CCCHHHHHHHHHHHH	31.46	21906983
298	Ubiquitination	GPSGLQAKLASLRKS CCCHHHHHHHHHHHH	31.46	21890473
301	Phosphorylation	GLQAKLASLRKSTKK HHHHHHHHHHHHCCC	38.86	24719451
305	Phosphorylation	KLASLRKSTKKRSES HHHHHHHHCCCCCCC	38.74	26434776
306	Phosphorylation	LASLRKSTKKRSESP HHHHHHHCCCCCCCC	43.55	26434776
308	Methylation	SLRKSTKKRSESPPA HHHHHCCCCCCCCCC	62.33	116252683
310	Phosphorylation	RKSTKKRSESPPAEL HHHCCCCCCCCCCCC	51.83	29255136
312	Phosphorylation	STKKRSESPPAELPS HCCCCCCCCCCCCCH	37.11	19664994
319	Phosphorylation	SPPAELPSLRRSTRQ CCCCCCCHHHHCCCC	47.32	30266825
327	Ubiquitination	LRRSTRQKTTGSCAS HHHCCCCCCCCCCCC	44.77	-
328	O-linked_Glycosylation	RRSTRQKTTGSCAST HHCCCCCCCCCCCCC	28.22	OGP
329	O-linked_Glycosylation	RSTRQKTTGSCASTS HCCCCCCCCCCCCCC	33.85	OGP
329	Phosphorylation	RSTRQKTTGSCASTS HCCCCCCCCCCCCCC	33.85	20068230
331	O-linked_Glycosylation	TRQKTTGSCASTSRR CCCCCCCCCCCCCCC	12.38	OGP
331	Phosphorylation	TRQKTTGSCASTSRR CCCCCCCCCCCCCCC	12.38	20068230
334	Phosphorylation	KTTGSCASTSRRGSG CCCCCCCCCCCCCCC	31.10	30576142
340	Phosphorylation	ASTSRRGSGLGKRGA CCCCCCCCCCCHHHH	29.09	30576142
340	Ubiquitination	ASTSRRGSGLGKRGA CCCCCCCCCCCHHHH	29.09	21890473
355	Ubiquitination	AEARRQEKMADPESN HHHHHHHHHCCCCHH	30.93	21906983
356	Sulfoxidation	EARRQEKMADPESNQ HHHHHHHHCCCCHHH	5.14	21406390
361	Phosphorylation	EKMADPESNQEAVNS HHHCCCCHHHHHHHH	49.56	-
369	Phosphorylation	NQEAVNSSAARTDEA HHHHHHHHHCCCCCC	22.27	-
373	Phosphorylation	VNSSAARTDEAPQGA HHHHHCCCCCCCCCC	33.20	24043423
387	Phosphorylation	AAGAVGMTTSGESES CCCCCCCCCCCCCCC	16.33	18669648
388	Phosphorylation	AGAVGMTTSGESESD CCCCCCCCCCCCCCC	26.33	24043423
389	Phosphorylation	GAVGMTTSGESESDD CCCCCCCCCCCCCCC	31.25	24043423
392	Phosphorylation	GMTTSGESESDDSEM CCCCCCCCCCCCCHH	46.02	24043423
393 (in isoform 2)	Phosphorylation	-	54.61	18669648
394	Phosphorylation	TTSGESESDDSEMGR CCCCCCCCCCCHHHH	56.87	24043423
397	Phosphorylation	GESESDDSEMGRLQA CCCCCCCCHHHHHHH	34.18	27251789
422	Methylation	LFGPLGPRMSQLFHR HCCCCCHHHHHHHHH	35.27	54560333
424	Phosphorylation	GPLGPRMSQLFHRTI CCCCHHHHHHHHHHH	25.63	23401153
435 (in isoform 3)	Phosphorylation	-	16.60	18669648
507	Phosphorylation	HACRALTYMMEALPR HHHHHHHHHHHHCCC	8.70	17053785
515	Phosphorylation	MMEALPRSSAVVVDA HHHHCCCCCCCCCCC	22.25	23403867
516	Phosphorylation	MEALPRSSAVVVDAI HHHCCCCCCCCCCCH	26.77	23403867
617	Malonylation	RLTHQDKKSVESTCL HCCCCCHHHHHHHHH	68.94	26320211
617	Ubiquitination	RLTHQDKKSVESTCL HCCCCCHHHHHHHHH	68.94	-
650	Phosphorylation	VASKDLLTNVQQLLV HHCHHHHHHHHHHHH	40.41	-
748	Phosphorylation	EGIFAVDTMLKKGNA CCEEEHHHHHHCCCC	20.15	25850435
751	Ubiquitination	FAVDTMLKKGNAQNT EEHHHHHHCCCCCCC	48.05	-
752	Ubiquitination	AVDTMLKKGNAQNTD EHHHHHHCCCCCCCC	54.13	-
758	Phosphorylation	KKGNAQNTDGAIWQW HCCCCCCCCCCCEEE	24.59	20068231
768	Ubiquitination	AIWQWRDDRGLWHPY CCEEEECCCCCCCCC	37.66	21890473
768	Ubiquitination	AIWQWRDDRGLWHPY CCEEEECCCCCCCCC	37.66	21890473
778	Ubiquitination	LWHPYNRIDSRIIEQ CCCCCCCCCHHHHHH	5.13	21890473
778	Ubiquitination	LWHPYNRIDSRIIEQ CCCCCCCCCHHHHHH	5.13	21890473
780	Phosphorylation	HPYNRIDSRIIEQIN CCCCCCCHHHHHHHH	24.02	24247654
792	Phosphorylation	QINEDTGTARAIQRK HHHCCCCCHHHHHCC	18.31	-
799	Ubiquitination	TARAIQRKPNPLANS CHHHHHCCCCCCCCC	32.54	21906983
809	Phosphorylation	PLANSNTSGYSESKK CCCCCCCCCCCCCHH	39.73	28555341
811	Phosphorylation	ANSNTSGYSESKKDD CCCCCCCCCCCHHHH	14.72	25839225
815	Ubiquitination	TSGYSESKKDDARAQ CCCCCCCHHHHHHHH	57.05	-
825	Ubiquitination	DARAQLMKEDPELAK HHHHHHHHHCHHHHH	68.50	-
832	Ubiquitination	KEDPELAKSFIKTLF HHCHHHHHHHHHHHH	59.53	-
833	Phosphorylation	EDPELAKSFIKTLFG HCHHHHHHHHHHHHH	26.96	24719451
936	Phosphorylation	QVKHLAESESLLTSP HHHHHHHCHHHCCCC	27.21	25867546
938	Phosphorylation	KHLAESESLLTSPPK HHHHHCHHHCCCCCC	37.65	25867546
941	Phosphorylation	AESESLLTSPPKACT HHCHHHCCCCCCCCC	44.47	30266825
942	Phosphorylation	ESESLLTSPPKACTN HCHHHCCCCCCCCCC	38.89	29255136
953	Phosphorylation	ACTNGSGSMGSTTSV CCCCCCCCCCCCCCC	22.97	30576142
977	Phosphorylation	HAAADLGSPSLQHSR HHHHHCCCCCCCCCC	20.72	30576142
979	Phosphorylation	AADLGSPSLQHSRDD HHHCCCCCCCCCCCC	42.21	26074081
983	Phosphorylation	GSPSLQHSRDDSLDL CCCCCCCCCCCCCCC	25.17	26074081
987	Phosphorylation	LQHSRDDSLDLSPQG CCCCCCCCCCCCCCC	28.24	30266825
989	Ubiquitination	HSRDDSLDLSPQGRL CCCCCCCCCCCCCCH	49.40	21890473
989	Ubiquitination	HSRDDSLDLSPQGRL CCCCCCCCCCCCCCH	49.40	21890473
991	Phosphorylation	RDDSLDLSPQGRLSD CCCCCCCCCCCCHHH	18.16	29255136
997	Phosphorylation	LSPQGRLSDVLKRKR CCCCCCHHHHHHHCC	25.06	23401153
1001	Ubiquitination	GRLSDVLKRKRLPKR CCHHHHHHHCCCCCC	56.58	21906983
1015	Phosphorylation	RGPRRPKYSPPRDDD CCCCCCCCCCCCCCC	29.14	30266825
1016	Phosphorylation	GPRRPKYSPPRDDDK CCCCCCCCCCCCCCC	34.26	29255136
1018	Ubiquitination	RRPKYSPPRDDDKVD CCCCCCCCCCCCCCC	46.52	21890473
1018	Ubiquitination	RRPKYSPPRDDDKVD CCCCCCCCCCCCCCC	46.52	21890473
1029	Ubiquitination	DKVDNQAKSPTTTQS CCCCCCCCCCCCCCC	47.40	-
1030	Phosphorylation	KVDNQAKSPTTTQSP CCCCCCCCCCCCCCC	30.41	23401153
1032	Phosphorylation	DNQAKSPTTTQSPKS CCCCCCCCCCCCCCH	49.95	23927012
1033	Phosphorylation	NQAKSPTTTQSPKSS CCCCCCCCCCCCCHH	26.65	23927012
1034	Phosphorylation	QAKSPTTTQSPKSSF CCCCCCCCCCCCHHH	29.54	23927012
1036	Phosphorylation	KSPTTTQSPKSSFLA CCCCCCCCCCHHHHH	32.00	23927012
1038	Ubiquitination	PTTTQSPKSSFLASL CCCCCCCCHHHHHHC	65.07	21906983
1038	Ubiquitination	PTTTQSPKSSFLASL CCCCCCCCHHHHHHC	65.07	21890473
1039	Phosphorylation	TTTQSPKSSFLASLN CCCCCCCHHHHHHCC	29.70	26074081
1040	Phosphorylation	TTQSPKSSFLASLNP CCCCCCHHHHHHCCC	30.33	26074081
1044	Phosphorylation	PKSSFLASLNPKTWG CCHHHHHHCCCCCCC	30.72	25159151
1048	Ubiquitination	FLASLNPKTWGRLST HHHHCCCCCCCCCCC	56.70	21906983
1048	Ubiquitination	FLASLNPKTWGRLST HHHHCCCCCCCCCCC	56.70	21890473
1049	Phosphorylation	LASLNPKTWGRLSTQ HHHCCCCCCCCCCCC	34.11	22199227
1054	Phosphorylation	PKTWGRLSTQSNSNN CCCCCCCCCCCCCCC	24.04	29255136
1055	Phosphorylation	KTWGRLSTQSNSNNI CCCCCCCCCCCCCCC	40.38	29255136
1057	Phosphorylation	WGRLSTQSNSNNIEP CCCCCCCCCCCCCCC	42.17	29255136
1059	Phosphorylation	RLSTQSNSNNIEPAR CCCCCCCCCCCCCCH	36.18	29255136
1067	Phosphorylation	NNIEPARTAGGSGLA CCCCCCHHCCCCHHH	31.59	-
1078	Phosphorylation	SGLARAASKDTISNN CHHHHHHCCCCHHCC	30.04	23401153
1079	Ubiquitination	GLARAASKDTISNNR HHHHHHCCCCHHCCH	54.91	-
1081	Phosphorylation	ARAASKDTISNNREK HHHHCCCCHHCCHHH	30.00	27794612
1083	Phosphorylation	AASKDTISNNREKIK HHCCCCHHCCHHHHH	30.09	26270265
1086	Ubiquitination	KDTISNNREKIKGWI CCCHHCCHHHHHHHH	51.33	21890473
1096	Ubiquitination	IKGWIKEQAHKFVER HHHHHHHHHHHHHHH	43.71	21890473
1104	Phosphorylation	AHKFVERYFSSENMD HHHHHHHHHCCCCCC	8.36	25850435
1106	Phosphorylation	KFVERYFSSENMDGS HHHHHHHCCCCCCCC	28.01	25850435
1107	Phosphorylation	FVERYFSSENMDGSN HHHHHHCCCCCCCCC	24.08	25850435
1113	Phosphorylation	SSENMDGSNPALNVL CCCCCCCCCHHHHHH	35.06	25850435
1146	Phosphorylation	ECLVEIRSIVSESDV EEEEEEHHEECCCCC	32.76	23898821
1149	Phosphorylation	VEIRSIVSESDVSSF EEEHHEECCCCCCCE	29.70	23898821
1151	Phosphorylation	IRSIVSESDVSSFEI EHHEECCCCCCCEEE	35.49	23898821
1154	Phosphorylation	IVSESDVSSFEIQHS EECCCCCCCEEEECC	34.01	23898821
1155	Phosphorylation	VSESDVSSFEIQHSG ECCCCCCCEEEECCH	27.09	23898821
1161	Phosphorylation	SSFEIQHSGFVKQLL CCEEEECCHHHHHHH	19.97	23898821
1170	Phosphorylation	FVKQLLLYLTSKSEK HHHHHHHHHHCCCHH	14.11	23898821
1172	Phosphorylation	KQLLLYLTSKSEKDA HHHHHHHHCCCHHHH	22.13	23898821
1173	Phosphorylation	QLLLYLTSKSEKDAV HHHHHHHCCCHHHHH	31.43	23898821
1174	Ubiquitination	LLLYLTSKSEKDAVS HHHHHHCCCHHHHHH	58.35	-
1177	Ubiquitination	YLTSKSEKDAVSREI HHHCCCHHHHHHHHH	59.06	-
1221	Ubiquitination	PLLALVHKMNNCLSQ HHHHHHHHHHHHHHH	35.52	-
1241	Phosphorylation	VKVHDFPSGNGTGGS CEEECCCCCCCCCCC	44.90	28450419
1245	Phosphorylation	DFPSGNGTGGSFSLN CCCCCCCCCCCCCCC	42.23	28450419
1248	Phosphorylation	SGNGTGGSFSLNRGS CCCCCCCCCCCCCCC	17.01	28450419
1250	Phosphorylation	NGTGGSFSLNRGSQA CCCCCCCCCCCCCHH	26.82	28450419
1259	Ubiquitination	NRGSQALKFFNTHQL CCCCHHHHHCCHHHH	51.42	21890473
1259	Ubiquitination	NRGSQALKFFNTHQL CCCCHHHHHCCHHHH	51.42	21890473
1267	Acetylation	FFNTHQLKCQLQRHP HCCHHHHHHHHHCCC	17.23	25953088
1267	Ubiquitination	FFNTHQLKCQLQRHP HCCHHHHHHHHHCCC	17.23	-
1280	Acetylation	HPDCANVKQWKGGPV CCCCCCCCCCCCCCC	50.69	19816199
1280	Ubiquitination	HPDCANVKQWKGGPV CCCCCCCCCCCCCCC	50.69	-
1283	Acetylation	CANVKQWKGGPVKID CCCCCCCCCCCCCCC	52.04	19816211
1283	Ubiquitination	CANVKQWKGGPVKID CCCCCCCCCCCCCCC	52.04	-
1288	Acetylation	QWKGGPVKIDPLALV CCCCCCCCCCHHHHH	44.52	23236377
1288	Ubiquitination	QWKGGPVKIDPLALV CCCCCCCCCCHHHHH	44.52	21890473
1288	Ubiquitination	QWKGGPVKIDPLALV CCCCCCCCCCHHHHH	44.52	21890473
1307	Ubiquitination	RYLVVRGYGRVREDD HHHHHCCCCCCCCCC	7.38	21890473
1317	Phosphorylation	VREDDEDSDDDGSDE CCCCCCCCCCCCCHH	40.67	26503892
1322	Phosphorylation	EDSDDDGSDEEIDES CCCCCCCCHHHHHHH	49.17	26503892
1329	Phosphorylation	SDEEIDESLAAQFLN CHHHHHHHHHHHHHH	21.40	28176443
1336	Ubiquitination	SLAAQFLNSGNVRHR HHHHHHHHCCCHHHE	49.51	21890473
1347	Phosphorylation	VRHRLQFYIGEHLLP HHHEEEEEECCCCCC	8.61	24043423
1355	Phosphorylation	IGEHLLPYNMTVYQA ECCCCCCCCCHHHHH	19.96	24043423
1358	Phosphorylation	HLLPYNMTVYQAVRQ CCCCCCCHHHHHHHH	16.66	24043423
1360	Phosphorylation	LPYNMTVYQAVRQFS CCCCCHHHHHHHHHC	5.00	24043423
1367	Phosphorylation	YQAVRQFSIQAEDER HHHHHHHCCCCCCCC	12.88	23927012
1374	Methylation	SIQAEDERESTDDES CCCCCCCCCCCCCCC	56.33	115918973
1376	Phosphorylation	QAEDERESTDDESNP CCCCCCCCCCCCCCC	43.27	26503892
1377	Phosphorylation	AEDERESTDDESNPL CCCCCCCCCCCCCCC	42.59	26503892
1381	Phosphorylation	RESTDDESNPLGRAG CCCCCCCCCCCCCCC	51.22	30266825
1399	Ubiquitination	KTHTIWYKPVREDEE ECEEEEEECCCCCHH	23.26	-
1421	Phosphorylation	GKRGRAQTAPTKTSP CCCCCCCCCCCCCCC	33.35	23927012
1424	Phosphorylation	GRAQTAPTKTSPRNA CCCCCCCCCCCCCCH	44.48	30266825
1425	Acetylation	RAQTAPTKTSPRNAK CCCCCCCCCCCCCHH	46.04	-
1425	Ubiquitination	RAQTAPTKTSPRNAK CCCCCCCCCCCCCHH	46.04	-
1426	Phosphorylation	AQTAPTKTSPRNAKK CCCCCCCCCCCCHHC	46.58	23401153
1427	Phosphorylation	QTAPTKTSPRNAKKH CCCCCCCCCCCHHCC	24.34	26846344
1500	Phosphorylation	MCKEIIPTSEFINSK CCCHHCCHHHHHHHH	30.40	21406692
1501	Phosphorylation	CKEIIPTSEFINSKL CCHHCCHHHHHHHHH	25.75	21406692
1506	Phosphorylation	PTSEFINSKLTAKAN CHHHHHHHHHHHHHH	24.99	21406692
1507	Ubiquitination	TSEFINSKLTAKANR HHHHHHHHHHHHHHH	45.42	-
1524	Phosphorylation	QDPLVIMTGNIPTWL CCCEEEEECCCHHHH	18.89	20068231
1529	Phosphorylation	IMTGNIPTWLTELGK EEECCCHHHHHHHHC	29.34	20068231
1532	Phosphorylation	GNIPTWLTELGKTCP CCCHHHHHHHHCCCC	22.26	20068231
1552	Phosphorylation	DTRQMLFYVTAFDRD CHHHHEEEEEECCHH	7.91	23663014
1554	Phosphorylation	RQMLFYVTAFDRDRA HHHEEEEEECCHHHH	15.38	23663014
1568	Phosphorylation	AMQRLLDTNPEINQS HHHHHHHCCCCCCCC	53.28	20873877
1575	Phosphorylation	TNPEINQSDSQDSRV CCCCCCCCCCCCCCH	34.44	29255136
1577	Phosphorylation	PEINQSDSQDSRVAP CCCCCCCCCCCCHHH	40.93	17525332
1580	Phosphorylation	NQSDSQDSRVAPRLD CCCCCCCCCHHHHHC	22.48	29255136
1592	Phosphorylation	RLDRKKRTVNREELL HHCHHCCCCCHHHHH	30.89	22817900
1600	Ubiquitination	VNREELLKQAESVMQ CCHHHHHHHHHHHHH	61.15	21906983
1661	Ubiquitination	EVTLSNPKGSQEGTK EEECCCCCCCHHHHH	75.37	21906983
1663	Phosphorylation	TLSNPKGSQEGTKYI ECCCCCCCHHHHHHH	31.05	-
1668	Ubiquitination	KGSQEGTKYIQNLQG CCCHHHHHHHHHHHH	51.73	-
1686	Ubiquitination	LPFGRTAKPAHIAKV CCCCCCCCCHHHHHH	41.97	-
1692	Ubiquitination	AKPAHIAKVKMKFRF CCCHHHHHHHHHHHH	41.61	-
1702	Ubiquitination	MKFRFLGKLMAKAIM HHHHHHHHHHHHHHH	36.92	-
1706	Ubiquitination	FLGKLMAKAIMDFRL HHHHHHHHHHHHHCC	25.20	-
1724	Ubiquitination	PLGLPFYKWMLRQET CCCCCHHHHHHHCCC	26.89	-
1766	Ubiquitination	KKRLEQDKSQTKESL HHHHHHCHHHHHHHH	44.13	-
1795	Phosphorylation	EDLGLDFTLPGFPNI HHCCCCCCCCCCCCE	31.54	26074081
1809	Ubiquitination	IELKKGGKDIPVTIH EEECCCCEECCEEEC	62.24	-
1814	Phosphorylation	GGKDIPVTIHNLEEY CCEECCEEECCHHHH	15.91	26074081
1840	Phosphorylation	GVSRQFDSFRDGFES CHHHHCHHHHCCCHH	24.38	22468782
1847	Phosphorylation	SFRDGFESVFPLSHL HHHCCCHHCCCHHHH	27.14	22468782
1852	Phosphorylation	FESVFPLSHLQYFYP CHHCCCHHHHHHHCH	23.53	22468782
1856	Phosphorylation	FPLSHLQYFYPEELD CCHHHHHHHCHHHHH	16.08	22468782
1877	Ubiquitination	KADTWDAKTLMECCR CCCCCCHHHHHHHCC	39.45	-
1937	Phosphorylation	RSLNPPLTIVRKTFE CCCCCCEEEEEHHHC	24.17	-
1941	Ubiquitination	PPLTIVRKTFESTEN CCEEEEEHHHCCCCC	46.82	-
1942	Phosphorylation	PLTIVRKTFESTENP CEEEEEHHHCCCCCH	23.28	-
1955	Phosphorylation	NPDDFLPSVMTCVNY CHHCHHHHHHHHHHH	27.03	-
1977	Ubiquitination	SIEIMREKLLIAARE HHHHHHHHHHHHHHC	37.92	-
1988	Phosphorylation	AAREGQQSFHLS--- HHHCCCCCCCCC---	13.52	27499020

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1078	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRIPC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRIPC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ULA1_HUMAN	NAE1	physical	18627766
CDN2A_HUMAN	CDKN2A	physical	20208519
ARF_HUMAN	CDKN2A	physical	20208519
MYC_HUMAN	MYC	physical	20208519
TRADD_HUMAN	TRADD	physical	22561347
NMI_HUMAN	NMI	physical	23034180
CDN2A_HUMAN	CDKN2A	physical	23034180
ARF_HUMAN	CDKN2A	physical	23034180
UB2D1_HUMAN	UBE2D1	physical	18627766
UB2D1_HUMAN	UBE2D1	physical	9575161
UB2L3_HUMAN	UBE2L3	physical	9575161
SOX6_HUMAN	SOX6	physical	23663701
UB2D1_HUMAN	UBE2D1	physical	23663701
GNL3_HUMAN	GNL3	physical	24769896
UB2D1_HUMAN	UBE2D1	physical	19028681
UBC_HUMAN	UBC	physical	19028681
PTF1A_HUMAN	PTF1A	physical	25355311
UBP7_HUMAN	USP7	physical	27800609

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRIPC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312; SER-991; SER-1317AND SER-1322, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310; SER-312; SER-991;SER-997; SER-1317 AND SER-1322, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312, AND MASSSPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1577, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-88 AND SER-1427,AND MASS SPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-991, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND THR-1592, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-507, AND MASSSPECTROMETRY.	17053785 [Abstract]