PTF1A_HUMAN - dbPTM
PTF1A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTF1A_HUMAN
UniProt AC Q7RTS3
Protein Name Pancreas transcription factor 1 subunit alpha
Gene Name PTF1A
Organism Homo sapiens (Human).
Sequence Length 328
Subcellular Localization Nucleus . Cytoplasm. In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity)..
Protein Description Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates..
Protein Sequence MDAVLLEHFPGGLDAFPSSYFDEDDFFTDQSSRDPLEDGDELLADEQAEVEFLSHQLHEYCYRDGACLLLQPAPPAAPLALAPPSSGGLGEPDDGGGGGYCCETGAPPGGFPYSPGSPPSCLAYPCAGAAVLSPGARLRGLSGAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGGGAGGCGGPGGGGRLGGDSPGSQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAKVWTPEDPRKLNSKSSFNNIENEPPFEFVS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
142PhosphorylationGARLRGLSGAAAAAA
CHHHHHHHHHHHHHH
29.25-
157PhosphorylationRRRRRVRSEAELQQL
HHHHHHCCHHHHHHH
38.0024670416
178PhosphorylationRERRRMQSINDAFEG
HHHHHHHHHHHHHHH
17.6428348404
192PhosphorylationGLRSHIPTLPYEKRL
HHHHHCCCCCHHHCC
39.5028348404
201AcetylationPYEKRLSKVDTLRLA
CHHHCCCHHHHHHHH
49.0418834332
201UbiquitinationPYEKRLSKVDTLRLA
CHHHCCCHHHHHHHH
49.04-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTF1A_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTF1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTF1A_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RBPJL_HUMANRBPJLphysical
18834332
TFE2_HUMANTCF3physical
18834332
RPGR1_HUMANRPGRIP1physical
25355311
CCDB1_HUMANCCNDBP1physical
25355311
TRIPC_HUMANTRIP12physical
25355311
ZW10_HUMANZW10physical
25355311
SPAT7_HUMANSPATA7physical
25355311
SUH_HUMANRBPJphysical
25355311
AAMP_HUMANAAMPphysical
25355311
CCD27_HUMANCCDC27physical
25355311
ITF2_HUMANTCF4physical
25355311

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTF1A_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP