UniProt ID | PTF1A_HUMAN | |
---|---|---|
UniProt AC | Q7RTS3 | |
Protein Name | Pancreas transcription factor 1 subunit alpha | |
Gene Name | PTF1A | |
Organism | Homo sapiens (Human). | |
Sequence Length | 328 | |
Subcellular Localization | Nucleus . Cytoplasm. In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity).. | |
Protein Description | Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.. | |
Protein Sequence | MDAVLLEHFPGGLDAFPSSYFDEDDFFTDQSSRDPLEDGDELLADEQAEVEFLSHQLHEYCYRDGACLLLQPAPPAAPLALAPPSSGGLGEPDDGGGGGYCCETGAPPGGFPYSPGSPPSCLAYPCAGAAVLSPGARLRGLSGAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGGGAGGCGGPGGGGRLGGDSPGSQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAKVWTPEDPRKLNSKSSFNNIENEPPFEFVS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
142 | Phosphorylation | GARLRGLSGAAAAAA CHHHHHHHHHHHHHH | 29.25 | - | |
157 | Phosphorylation | RRRRRVRSEAELQQL HHHHHHCCHHHHHHH | 38.00 | 24670416 | |
178 | Phosphorylation | RERRRMQSINDAFEG HHHHHHHHHHHHHHH | 17.64 | 28348404 | |
192 | Phosphorylation | GLRSHIPTLPYEKRL HHHHHCCCCCHHHCC | 39.50 | 28348404 | |
201 | Acetylation | PYEKRLSKVDTLRLA CHHHCCCHHHHHHHH | 49.04 | 18834332 | |
201 | Ubiquitination | PYEKRLSKVDTLRLA CHHHCCCHHHHHHHH | 49.04 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTF1A_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTF1A_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTF1A_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
RBPJL_HUMAN | RBPJL | physical | 18834332 | |
TFE2_HUMAN | TCF3 | physical | 18834332 | |
RPGR1_HUMAN | RPGRIP1 | physical | 25355311 | |
CCDB1_HUMAN | CCNDBP1 | physical | 25355311 | |
TRIPC_HUMAN | TRIP12 | physical | 25355311 | |
ZW10_HUMAN | ZW10 | physical | 25355311 | |
SPAT7_HUMAN | SPATA7 | physical | 25355311 | |
SUH_HUMAN | RBPJ | physical | 25355311 | |
AAMP_HUMAN | AAMP | physical | 25355311 | |
CCD27_HUMAN | CCDC27 | physical | 25355311 | |
ITF2_HUMAN | TCF4 | physical | 25355311 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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