CCD27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD27_HUMAN
• UniProt AC: Q2M243
• Protein Name: Coiled-coil domain-containing protein 27
• Gene Name: CCDC27
• Organism: Homo sapiens (Human).
• Sequence Length: 656
• Protein Sequence: MFEAIFPSTPQARLKRDPREKPGLSSFRSTFRQQSSLGLCIPRLMLPKEASPSQRHSSMSSSMARALVLLQSMASRDARCPEWKPHQKPRTLSKSVQTISRYYRKTSEPKDAASLTGFMSKMELRRVFPTHPDCPQFSTRATSMSHCGSPTEADLSGEIDNSSETWRGTQDLFLARRGSDTNVDGYLLPFSKSICEFDYLRKRRKSQTLSPVTSSSVASQSCLRKRMPWYLSVIHEKDHCLSELEIQVQKKDEEILLLQEEREALKMQLKCLLKGKGQETSMSPGRREQLSDASLKLGRLSLLKAFSRHEEELQHWWQMQEESAAPERGKEPDLGGGEEDEGLEGEPDGVEDTGAWGGVSQMGSVHEEGSEEEEEEEGDRDEDSEERELPEEEEIPRRRASSLAESFEEELLAQLEEYEQVILDFQFNLEATRTRYSLATGVIASLQQQVDFQETQLRKINTENETLQKELRERRQQLQAMTDKFSNLREDKKHQEMMGLIEKDNQLLRQQVSELERKLTKRDCVISELDTKVSQLQEQVELDQNHLQRWKQLQEDLQSKKEMIQQAEQHTRVALESSQSRLERLRNKIIQATFSISGTKSLANEISDNDILEALQRIISERSDYYNQLKQKGVKVPPLQQSEAFLTSKSKKGTSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	IPRLMLPKEASPSQR CCHHHCCCCCCHHHC	63.05	-
91	Phosphorylation	KPHQKPRTLSKSVQT CCCCCCCCCCHHHHH	43.86	-
100	Phosphorylation	SKSVQTISRYYRKTS CHHHHHHHHHHHCCC	20.02	-
106	Phosphorylation	ISRYYRKTSEPKDAA HHHHHHCCCCCCCHH	29.35	25693802
107	Phosphorylation	SRYYRKTSEPKDAAS HHHHHCCCCCCCHHH	55.74	25693802
114	Phosphorylation	SEPKDAASLTGFMSK CCCCCHHHHCHHHHH	28.34	30622161
116	Phosphorylation	PKDAASLTGFMSKME CCCHHHHCHHHHHHH	26.36	30622161
120	Phosphorylation	ASLTGFMSKMELRRV HHHCHHHHHHHHHHH	26.96	30622161
142	Phosphorylation	PQFSTRATSMSHCGS CCCCCCCCCCCCCCC	22.98	22817900
143	Phosphorylation	QFSTRATSMSHCGSP CCCCCCCCCCCCCCC	19.80	25693802
145	Phosphorylation	STRATSMSHCGSPTE CCCCCCCCCCCCCCC	18.52	25693802
149	Phosphorylation	TSMSHCGSPTEADLS CCCCCCCCCCCHHHC	33.76	25693802
151	Phosphorylation	MSHCGSPTEADLSGE CCCCCCCCCHHHCCC	45.57	25693802
156	Phosphorylation	SPTEADLSGEIDNSS CCCCHHHCCCCCCCC	34.62	22817900
162	Phosphorylation	LSGEIDNSSETWRGT HCCCCCCCCCCCCCH	26.29	25693802
163	Phosphorylation	SGEIDNSSETWRGTQ CCCCCCCCCCCCCHH	45.35	25693802
165	Phosphorylation	EIDNSSETWRGTQDL CCCCCCCCCCCHHHE	23.55	25693802
179	Phosphorylation	LFLARRGSDTNVDGY EEEEECCCCCCCCCC	39.18	30622161
181	Phosphorylation	LARRGSDTNVDGYLL EEECCCCCCCCCCEE	38.55	30622161
193	Phosphorylation	YLLPFSKSICEFDYL CEECCCHHHHHHHHH	31.13	30622161
206	Phosphorylation	YLRKRRKSQTLSPVT HHHHHCCCCCCCCCC	26.96	25693802
208	Phosphorylation	RKRRKSQTLSPVTSS HHHCCCCCCCCCCCC	35.97	25693802
210	Phosphorylation	RRKSQTLSPVTSSSV HCCCCCCCCCCCCHH	22.25	25693802
213	Phosphorylation	SQTLSPVTSSSVASQ CCCCCCCCCCHHHCH	26.69	30622161
214	Phosphorylation	QTLSPVTSSSVASQS CCCCCCCCCHHHCHH	22.35	30622161
215	Phosphorylation	TLSPVTSSSVASQSC CCCCCCCCHHHCHHH	21.33	30622161
216	Phosphorylation	LSPVTSSSVASQSCL CCCCCCCHHHCHHHH	22.82	30622161
230	Phosphorylation	LRKRMPWYLSVIHEK HHHHCCCHHHHHHHH	5.34	29083192
232	Phosphorylation	KRMPWYLSVIHEKDH HHCCCHHHHHHHHCC	11.88	29083192
242	Phosphorylation	HEKDHCLSELEIQVQ HHHCCHHCCEEEEEE	45.59	30622161
280	Phosphorylation	LKGKGQETSMSPGRR HCCCCCCCCCCCCCH	23.11	23403867
281	Phosphorylation	KGKGQETSMSPGRRE CCCCCCCCCCCCCHH	19.26	23403867
283	Phosphorylation	KGQETSMSPGRREQL CCCCCCCCCCCHHHH	24.78	23403867
291	Phosphorylation	PGRREQLSDASLKLG CCCHHHHCHHHHHHH	30.72	30108239
294	Phosphorylation	REQLSDASLKLGRLS HHHHCHHHHHHHHHH	30.90	30108239
301	Phosphorylation	SLKLGRLSLLKAFSR HHHHHHHHHHHHHHH	30.23	24719451
307	Phosphorylation	LSLLKAFSRHEEELQ HHHHHHHHHCHHHHH	37.27	30622161
462	Phosphorylation	TQLRKINTENETLQK HHHHHHHHCCHHHHH	43.60	29083192
466	Phosphorylation	KINTENETLQKELRE HHHHCCHHHHHHHHH	46.18	29083192
595	Phosphorylation	KIIQATFSISGTKSL HHHHHHHHCCCCHHH	16.10	22210691
599	Phosphorylation	ATFSISGTKSLANEI HHHHCCCCHHHHHCC	15.63	22210691
642	Phosphorylation	KVPPLQQSEAFLTSK CCCCCCCCHHHHHCC	20.24	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD27_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
100	Phosphorylation	104 (4)	R ⇒ K	rs76597070	Obesity-related traits	23251661

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLH2_HUMAN	CLTCL1	physical	28514442
LOXE3_HUMAN	ALOXE3	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
LX12B_HUMAN	ALOX12B	physical	28514442
WASF2_HUMAN	WASF2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.