LX12B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LX12B_HUMAN
• UniProt AC: O75342
• Protein Name: Arachidonate 12-lipoxygenase, 12R-type
• Gene Name: ALOX12B
• Organism: Homo sapiens (Human).
• Sequence Length: 701
• Subcellular Localization: Cytoplasm .
• Protein Description: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins..
• Protein Sequence: MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MATYKVRVATG ----CCEEEEEEECC	9.65	24719451
10	Phosphorylation	TYKVRVATGTDLLSG EEEEEEECCCCCCCC	37.44	36013147
12	Phosphorylation	KVRVATGTDLLSGTR EEEEECCCCCCCCCC	21.08	20068231
16	Phosphorylation	ATGTDLLSGTRDSIS ECCCCCCCCCCCEEE	45.47	25627689
18	Phosphorylation	GTDLLSGTRDSISLT CCCCCCCCCCEEEEE	28.11	20068231
161	Phosphorylation	PSYVHIPSYRPPVRR CCCCCCCCCCCCCCC	32.92	24719451
170	Methylation	RPPVRRHRNPNRPEW CCCCCCCCCCCCCCC	59.49	-
203	Phosphorylation	LNLNLRYSFLKTASF CCCCCHHHHHHHHHH	20.05	24719451
302	Phosphorylation	APFLGEGTCLQAELE HHHCCCCEEEEEEHH	13.02	46162601
318	Phosphorylation	GNIYLADYRIMEGIP CCEEEEECEEECCCC	9.09	46162619
326	Phosphorylation	RIMEGIPTVELSGRK EEECCCCEEECCCCC	25.37	46162607
330	Phosphorylation	GIPTVELSGRKQHHC CCCEEECCCCCCCCC	24.05	46162595
433	Phosphorylation	LLIPHTRYTVQINSI HHCCCCCEEEEECCC	16.65	21406692
434	Phosphorylation	LIPHTRYTVQINSIG HCCCCCEEEEECCCC	11.57	21406692
439	Phosphorylation	RYTVQINSIGRAVLL CEEEEECCCCCEEEE	28.22	21406692
496	Phosphorylation	GVQDLPGYYYRDDSL CCCCCCCCEECCHHH	8.72	7336111
497	Phosphorylation	VQDLPGYYYRDDSLA CCCCCCCEECCHHHH	9.65	7336121
572	Phosphorylation	RYVTIVIYTCSAKHA HHHHEEEEECCCHHH	7.27	22210691
573	Phosphorylation	YVTIVIYTCSAKHAA HHHEEEEECCCHHHH	6.72	22210691
606	Phosphorylation	MRNPPIQTKGLTTLE HCCCCCCCCCCCHHH	28.00	46162613
610	Phosphorylation	PIQTKGLTTLETFMD CCCCCCCCHHHHHHH	37.69	29449344
611	Phosphorylation	IQTKGLTTLETFMDT CCCCCCCHHHHHHHH	27.86	29449344
614	Phosphorylation	KGLTTLETFMDTLPD CCCCHHHHHHHHCCC	27.63	29449344
618	Phosphorylation	TLETFMDTLPDVKTT HHHHHHHHCCCHHHH	28.53	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LX12B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LX12B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LX12B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LX12B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 242100: Ichthyosis, congenital, autosomal recessive 2 (ARCI2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.