ATPK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPK_MOUSE
• UniProt AC: P56135
• Protein Name: ATP synthase subunit f, mitochondrial
• Gene Name: Atp5j2
• Organism: Mus musculus (Mouse).
• Sequence Length: 88
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane..
• Protein Sequence: MASLVPLKEKKLMEVKLGELPSWIMMRDFTPSGIAGAFRRGYDRYYNKYINVRKGSISGISMVLAAYVVFSYCISYKELKHERRRKYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASLVPLKE ------CCCCCCCCC	16.15	-
3	Phosphorylation	-----MASLVPLKEK -----CCCCCCCCCC	28.71	23737553
8	Acetylation	MASLVPLKEKKLMEV CCCCCCCCCCCCCEE	62.51	23576753
8	Malonylation	MASLVPLKEKKLMEV CCCCCCCCCCCCCEE	62.51	26320211
8	Succinylation	MASLVPLKEKKLMEV CCCCCCCCCCCCCEE	62.51	26388266
10	Acetylation	SLVPLKEKKLMEVKL CCCCCCCCCCCEEEC	50.01	24062335
11	Acetylation	LVPLKEKKLMEVKLG CCCCCCCCCCEEECC	54.91	24062335
16	Acetylation	EKKLMEVKLGELPSW CCCCCEEECCCCCCE	37.15	23576753
16	Succinylation	EKKLMEVKLGELPSW CCCCCEEECCCCCCE	37.15	24315375
30	Phosphorylation	WIMMRDFTPSGIAGA EEECCCCCCCCHHHH	22.34	22817900
32	Phosphorylation	MMRDFTPSGIAGAFR ECCCCCCCCHHHHHH	39.51	22817900
48	Acetylation	GYDRYYNKYINVRKG CHHHHHCCCEEECCC	31.24	23864654
48	Ubiquitination	GYDRYYNKYINVRKG CHHHHHCCCEEECCC	31.24	22790023
80	Acetylation	CISYKELKHERRRKY HCCHHHHHHHHHHCC	44.50	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ATPK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.