ACTC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTC_MOUSE
• UniProt AC: P68033
• Protein Name: Actin, alpha cardiac muscle 1
• Gene Name: Actc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 377
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
• Protein Sequence: MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCDDEETTA ------CCCHHHCEE	10.18	-
3	Acetylation	-----MCDDEETTAL -----CCCHHHCEEE	66.12	-
7	Phosphorylation	-MCDDEETTALVCDN -CCCHHHCEEEEEEC	18.47	62000689
8	Phosphorylation	MCDDEETTALVCDNG CCCHHHCEEEEEECC	22.67	62000695
35	Phosphorylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	26824392
46	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	23911929
49	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	23911929
52	Acetylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	15605069
52	Ubiquitination	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	-
54	Phosphorylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	25521595
55	Phosphorylation	GMGQKDSYVGDEAQS ECCCCCCCCCCHHHC	20.70	26824392
62	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	27087446
63	Acetylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	15603151
63	Ubiquitination	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	-
68	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	27600695
70	Acetylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	22646653
70	Ubiquitination	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	-
71	Phosphorylation	RGILTLKYPIEHGII CCEEEEECEECCCCC	16.74	26239621
75	Methylation	TLKYPIEHGIITNWD EEECEECCCCCCCHH	33.21	-
79	Phosphorylation	PIEHGIITNWDDMEK EECCCCCCCHHHHHH	28.47	36012721
86	Acetylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	30586027
86	Ubiquitination	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-
86	Methylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-
91	O-linked_Glycosylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	20307999
91	Phosphorylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	22499769
93	Phosphorylation	KIWHHTFYNELRVAP HHHHHHHHCCCCCCC	14.64	27742792
105	Phosphorylation	VAPEEHPTLLTEAPL CCCCCCCCCCCCCCC	35.99	28542873
105	O-linked_Glycosylation	VAPEEHPTLLTEAPL CCCCCCCCCCCCCCC	35.99	30016717
108	Phosphorylation	EEHPTLLTEAPLNPK CCCCCCCCCCCCCCC	32.96	22210690
115	Ubiquitination	TEAPLNPKANREKMT CCCCCCCCCCHHHHH	58.16	-
143	Phosphorylation	VAIQAVLSLYASGRT HHHHHHHHHHHCCCC	16.85	19060867
145	Phosphorylation	IQAVLSLYASGRTTG HHHHHHHHHCCCCEE	8.71	36642107
147	Phosphorylation	AVLSLYASGRTTGIV HHHHHHHCCCCEEEE	18.43	-
150	Phosphorylation	SLYASGRTTGIVLDS HHHHCCCCEEEEEEC	32.66	22210690
151	Phosphorylation	LYASGRTTGIVLDSG HHHCCCCEEEEEECC	24.45	22210690
157	Phosphorylation	TTGIVLDSGDGVTHN CEEEEEECCCCCCCC	34.32	28542873
168	Phosphorylation	VTHNVPIYEGYALPH CCCCCCEECCCCHHH	9.38	28464351
171	Phosphorylation	NVPIYEGYALPHAIM CCCEECCCCHHHHHH	7.94	36642093
188	Phosphorylation	DLAGRDLTDYLMKIL HCCCCCHHHHHHHHH	27.21	24899341
190	Phosphorylation	AGRDLTDYLMKILTE CCCCHHHHHHHHHHH	11.94	2001175
193	Acetylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	22646661
193	Ubiquitination	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	-
196	Phosphorylation	DYLMKILTERGYSFV HHHHHHHHHCCCCCE	27.40	46158553
200	Phosphorylation	KILTERGYSFVTTAE HHHHHCCCCCEEHHC	12.73	36642141
201	Phosphorylation	ILTERGYSFVTTAER HHHHCCCCCEEHHCH	18.96	35093905
201	O-linked_Glycosylation	ILTERGYSFVTTAER HHHHCCCCCEEHHCH	18.96	30016717
204	Phosphorylation	ERGYSFVTTAEREIV HCCCCCEEHHCHHHH	20.48	24899341
205	Phosphorylation	RGYSFVTTAEREIVR CCCCCEEHHCHHHHH	22.63	24899341
215	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHCEEE	53.75	15604249
217	Ubiquitination	IVRDIKEKLCYVALD HHHHHHHHHCEEEEE	38.56	-
220	Phosphorylation	DIKEKLCYVALDFEN HHHHHHCEEEEECCH	10.13	24351
231	Phosphorylation	DFENEMATAASSSSL ECCHHHHHHCCCCCC	22.80	23737553
234	Phosphorylation	NEMATAASSSSLEKS HHHHHHCCCCCCCHH	28.43	23737553
235	Phosphorylation	EMATAASSSSLEKSY HHHHHCCCCCCCHHE	21.15	23737553
236	Phosphorylation	MATAASSSSLEKSYE HHHHCCCCCCCHHEE	36.13	23737553
237	Phosphorylation	ATAASSSSLEKSYEL HHHCCCCCCCHHEEC	42.36	23737553
241	O-linked_Glycosylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	19531637
241	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	25521595
242	Phosphorylation	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	24925903
251	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	46158343
262	Phosphorylation	ERFRCPETLFQPSFI CEECCCCHHCCCCCC	20.29	22817900
267	Phosphorylation	PETLFQPSFIGMESA CCHHCCCCCCCHHCC	20.79	46158271
281	Phosphorylation	AGIHETTYNSIMKCD CCCCCCCCHHHHCCC	17.84	15569657
293	Ubiquitination	KCDIDIRKDLYANNV CCCCEECHHHHHCCC	53.04	22790023
305	Phosphorylation	NNVLSGGTTMYPGIA CCCCCCCCCCCCCHH	16.35	21082442
308	Phosphorylation	LSGGTTMYPGIADRM CCCCCCCCCCHHHHH	9.01	-
317	Ubiquitination	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	-
317	Acetylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	51083201
320	Phosphorylation	DRMQKEITALAPSTM HHHHHHHHHHCCCCE	19.40	25521595
325	Phosphorylation	EITALAPSTMKIKII HHHHHCCCCEEEEEE	35.21	25521595
326	Phosphorylation	ITALAPSTMKIKIIA HHHHCCCCEEEEEEC	22.79	46158475
328	Acetylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	15603727
328	Ubiquitination	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
330	Acetylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	15626291
330	Ubiquitination	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	-
364	Phosphorylation	MWISKQEYDEAGPSI HHHCHHHHCCCCCCC	19.31	28542873
370	Phosphorylation	EYDEAGPSIVHRKCF HHCCCCCCCCCCCCC	36.00	27742792

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTC_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
46	M	Oxidation	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	23911929
49	M	Oxidation	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	23911929
75	H	Methylation	Methylated at His-75 by SETD3.	-
86	K	Methylation	Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.