NUP85_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP85_MOUSE
• UniProt AC: Q8R480
• Protein Name: Nuclear pore complex protein Nup85
• Gene Name: Nup85
• Organism: Mus musculus (Mouse).
• Sequence Length: 656
• Subcellular Localization: Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Nucleus membrane . During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytop
• Protein Description: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade..
• Protein Sequence: MEELDCEPAVTWIPGVNSKKKQMCFDWGPGEMLLCETSFNQTGKSEKVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFVGLQKIEEELSGKSRKAQLVRVSKNYRSVIRACMEEMHQVAIAAKDPASGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGGDNPSKHENFWDLVTVLVLQGRLDEARQMLAKEADANPSCAGMCRVLGDLMRTMPILSPGNTQTLTELELKWQHWREECERHLQDNTFAANPRLESLCKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHFYAQSSLDMFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCRLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVKSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGSAMMLSDRLTFLGKYREFHRLYGEKRFGDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLASGRPECGEPDAQRLQDDDIETTKVEMLRLALARNLARAIIREGSLEGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEELDCEP -------CCCCCCCC	9.01	-
37	Ubiquitination	GEMLLCETSFNQTGK CCEEEEEEECCCCCC	37.31	27667366
47	Ubiquitination	NQTGKSEKVPSCPFI CCCCCCCCCCCCCEE	67.54	22790023
51	S-palmitoylation	KSEKVPSCPFIYIIR CCCCCCCCCEEEEEE	2.33	28526873
59	Ubiquitination	PFIYIIRKDVDVYSQ CEEEEEECCHHHHHH	52.25	22790023
70	Ubiquitination	VYSQILRKLFNESHG HHHHHHHHHHHHCCC	54.72	27667366
81	Ubiquitination	ESHGIFVGLQKIEEE HCCCEEEEHHHHHHH	16.19	27667366
90	Phosphorylation	QKIEEELSGKSRKAQ HHHHHHHCCCCCCHH	47.67	29514104
92	Ubiquitination	IEEELSGKSRKAQLV HHHHHCCCCCCHHHH	43.65	27667366
92	Malonylation	IEEELSGKSRKAQLV HHHHHCCCCCCHHHH	43.65	26320211
92	Acetylation	IEEELSGKSRKAQLV HHHHHCCCCCCHHHH	43.65	23806337
103	Ubiquitination	AQLVRVSKNYRSVIR HHHHHHCHHHHHHHH	55.96	27667366
218	Ubiquitination	EARQMLAKEADANPS HHHHHHHHHCCCCHH	49.85	22790023
314	Phosphorylation	FLVTRLLYSNPTVKP HHHHHHHHCCCCCCC	15.82	22802335
369	Phosphorylation	KECSIALSNWWFVAH HHHHHHHCCHHHHHH	22.76	22802335
378	Phosphorylation	WWFVAHLTDLLDHCR HHHHHHHHHHHHHHH	18.09	22802335
389	Phosphorylation	DHCRLLQSHNLYFGS HHHHHHHHCCCCCCC	17.82	22802335
393	Phosphorylation	LLQSHNLYFGSNMRE HHHHCCCCCCCCHHH	15.94	22802335
396	Phosphorylation	SHNLYFGSNMREFLL HCCCCCCCCHHHHHH	19.97	22802335
494	Acetylation	LSWSIRAKDAAFATL HHHHHHHHHHHHHHH	37.74	7614455
598	Phosphorylation	IFSAEQTYELMRCLE EECHHHHHHHHHHHH	13.53	26487105
631	Ubiquitination	DDDIETTKVEMLRLA CCCCHHHHHHHHHHH	43.55	22790023
652	Phosphorylation	RAIIREGSLEGS--- HHHHHHCCCCCC---	20.63	25266776
656	Phosphorylation	REGSLEGS------- HHCCCCCC-------	27.89	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP85_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP85_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP85_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NUP85_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.