VPS41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS41_MOUSE
• UniProt AC: Q5KU39
• Protein Name: Vacuolar protein sorting-associated protein 41 homolog
• Gene Name: Vps41
• Organism: Mus musculus (Mouse).
• Sequence Length: 853
• Subcellular Localization: Endosome membrane . Late endosome . Lysosome . Golgi apparatus, trans-Golgi network . Early endosome . Cytoplasmic vesicle, clathrin-coated vesicle .
• Protein Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion. Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS. Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex. May play a role in HOPS-independent function in the regulated secretory pathway (By similarity)..
• Protein Sequence: MAEAEEQETESLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHETFDCPIKIIAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQRISNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQRNIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICSAKNRGPGSAILEMKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AEAEEQETESLEEST CCHHHHHHHHHHHCC	30.48	25338131
11	Phosphorylation	AEEQETESLEESTDE HHHHHHHHHHHCCCC	48.80	25338131
15	Phosphorylation	ETESLEESTDESEEE HHHHHHHCCCCCHHH	31.61	25293948
16	Phosphorylation	TESLEESTDESEEES HHHHHHCCCCCHHHC	47.25	25293948
19	Phosphorylation	LEESTDESEEESEEE HHHCCCCCHHHCCCC	53.79	25293948
197	Phosphorylation	GVKVFDITSKQRISN CCEEEECCCCHHHCC	31.54	-
198	Phosphorylation	VKVFDITSKQRISNV CEEEECCCCHHHCCC	27.42	-
248	Phosphorylation	SVKERHASEMRDLPS EHHHHHHHHHHCCCH	26.29	25338131
447	Phosphorylation	QLKAISPYLPRGDPV CCEECCCCCCCCCCC	23.65	28285833
617	Phosphorylation	RYHEKQISLYAEYDR CCCHHHEEEEEEECC	16.91	25338131
619	Phosphorylation	HEKQISLYAEYDRPN CHHHEEEEEEECCCC	7.21	25338131
622	Phosphorylation	QISLYAEYDRPNLLP HEEEEEEECCCCCHH	14.74	25338131
761	Ubiquitination	LLREGCKKILVADSL HHCCCCCHHHHHHHH	45.40	22790023
772	Ubiquitination	ADSLSLLKKMHRTQM HHHHHHHHHHHHHCC	54.03	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS41_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS41_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGFA1_HUMAN	TGFBRAP1	physical	26496610
BABA1_HUMAN	BABAM1	physical	26496610
DDX41_HUMAN	DDX41	physical	26496610
VPS11_HUMAN	VPS11	physical	26496610
VPS18_HUMAN	VPS18	physical	26496610
VPS16_HUMAN	VPS16	physical	26496610
VP33A_HUMAN	VPS33A	physical	26496610
F111B_HUMAN	FAM111B	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.