F111B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F111B_HUMAN
• UniProt AC: Q6SJ93
• Protein Name: Protein FAM111B
• Gene Name: FAM111B
• Organism: Homo sapiens (Human).
• Sequence Length: 734
• Protein Sequence: MNSMKTEENKSFSAMEDDQRTRPEVSKDTVMKQTHADTPVDHCLSGIRKCSSTFKLKSEVNKHETALEMQNPNLNNKECCFTFTLNGNSRKLDRSVFTAYGKPSESIYSALSANDYFSERIKNQFNKNIIVYEEKTIDGHINLGMPLKCLPSDSHFKITFGQRKSSKEDGHILRQCENPNMECILFHVVAIGRTRKKIVKINELHEKGSKLCIYALKGETIEGALCKDGRFRSDIGEFEWKLKEGHKKIYGKQSMVDEVSGKVLEMDISKKKALQQKDIHKKIKQNESATDEINHQSLIQSKKKVHKPKKDGETKDVEHSREQILPPQDLSHYIKDKTRQTIPRIRNYYFCSLPRKYRQINSQVRRRPHLGRRYAINLDVQKEAINLLKNYQTLNEAIMHQYPNFKEEAQWVRKYFREEQKRMNLSPAKQFNIYKKDFGKMTANSVSVATCEQLTYYSKSVGFMQWDNNGNTGNATCFVFNGGYIFTCRHVVHLMVGKNTHPSLWPDIISKCAKVTFTYTEFCPTPDNWFSIEPWLKVSNENLDYAILKLKENGNAFPPGLWRQISPQPSTGLIYLIGHPEGQIKKIDGCTVIPLNERLKKYPNDCQDGLVDLYDTTSNVYCMFTQRSFLSEVWNTHTLSYDTCFSDGSSGSPVFNASGKLVALHTFGLFYQRGFNVHALIEFGYSMDSILCDIKKTNESLYKSLNDEKLETYDEEKGKQESSLQDHQIEPMEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNSMKTEE -------CCCCCCCC	8.27	22814378
3	Phosphorylation	-----MNSMKTEENK -----CCCCCCCCCC	21.98	-
5	Acetylation	---MNSMKTEENKSF ---CCCCCCCCCCCC	53.24	25953088
5	Sumoylation	---MNSMKTEENKSF ---CCCCCCCCCCCC	53.24	-
5	Sumoylation	---MNSMKTEENKSF ---CCCCCCCCCCCC	53.24	-
6	Phosphorylation	--MNSMKTEENKSFS --CCCCCCCCCCCCC	39.63	24114839
10	Ubiquitination	SMKTEENKSFSAMED CCCCCCCCCCCCCCC	57.04	29967540
11	Phosphorylation	MKTEENKSFSAMEDD CCCCCCCCCCCCCCC	35.70	21815630
13	Phosphorylation	TEENKSFSAMEDDQR CCCCCCCCCCCCCCC	33.52	22199227
19	Ubiquitination	FSAMEDDQRTRPEVS CCCCCCCCCCCCCCC	62.05	29967540
27	Ubiquitination	RTRPEVSKDTVMKQT CCCCCCCHHHHHHHH	63.69	23000965
32	Ubiquitination	VSKDTVMKQTHADTP CCHHHHHHHHCCCCC	47.94	21890473
32 (in isoform 2)	Ubiquitination	-	47.94	21890473
38	Phosphorylation	MKQTHADTPVDHCLS HHHHCCCCCHHHHHH	26.45	28555341
45	Phosphorylation	TPVDHCLSGIRKCSS CCHHHHHHHHHHCCC	37.25	24719451
49	Ubiquitination	HCLSGIRKCSSTFKL HHHHHHHHCCCCEEE	36.23	29967540
53	Phosphorylation	GIRKCSSTFKLKSEV HHHHCCCCEEEECHH	14.43	-
55	Methylation	RKCSSTFKLKSEVNK HHCCCCEEEECHHCH	55.91	-
57	Ubiquitination	CSSTFKLKSEVNKHE CCCCEEEECHHCHHH	45.20	22817900
62	Ubiquitination	KLKSEVNKHETALEM EEECHHCHHHHHHHH	48.25	22817900
62 (in isoform 1)	Ubiquitination	-	48.25	21890473
72	Ubiquitination	TALEMQNPNLNNKEC HHHHHCCCCCCCCCE	29.78	29967540
92	Ubiquitination	LNGNSRKLDRSVFTA ECCCCCEEEHHHHHC	6.86	29967540
97	Ubiquitination	RKLDRSVFTAYGKPS CEEEHHHHHCCCCCC	3.22	29967540
98	Phosphorylation	KLDRSVFTAYGKPSE EEEHHHHHCCCCCCH	19.47	28787133
100	Phosphorylation	DRSVFTAYGKPSESI EHHHHHCCCCCCHHH	23.71	-
102	Ubiquitination	SVFTAYGKPSESIYS HHHHCCCCCCHHHHH	32.47	29967540
106	Phosphorylation	AYGKPSESIYSALSA CCCCCCHHHHHHHHH	31.03	28787133
108	Phosphorylation	GKPSESIYSALSAND CCCCHHHHHHHHHCH	9.36	-
109	Phosphorylation	KPSESIYSALSANDY CCCHHHHHHHHHCHH	22.51	28787133
112	Phosphorylation	ESIYSALSANDYFSE HHHHHHHHHCHHHHH	25.41	28787133
118	Ubiquitination	LSANDYFSERIKNQF HHHCHHHHHHHHHHC	21.53	29967540
122	Ubiquitination	DYFSERIKNQFNKNI HHHHHHHHHHCCCCE	51.41	29967540
127	Ubiquitination	RIKNQFNKNIIVYEE HHHHHCCCCEEEEEE	51.30	29967540
132	Phosphorylation	FNKNIIVYEEKTIDG CCCCEEEEEEEEECC	14.15	30622161
134	Ubiquitination	KNIIVYEEKTIDGHI CCEEEEEEEEECCCE	37.50	23000965
137	Ubiquitination	IVYEEKTIDGHINLG EEEEEEEECCCEECC	9.89	23000965
148	Ubiquitination	INLGMPLKCLPSDSH EECCCCCEECCCCCC	28.05	29967540
164	Ubiquitination	KITFGQRKSSKEDGH EEEECCCCCCCCCCC	51.71	23000965
167	Ubiquitination	FGQRKSSKEDGHILR ECCCCCCCCCCCHHH	67.90	23000965
170	Ubiquitination	RKSSKEDGHILRQCE CCCCCCCCCHHHHCC	15.72	29967540
177	Ubiquitination	GHILRQCENPNMECI CCHHHHCCCCCCCEE	68.34	29967540
197	Ubiquitination	AIGRTRKKIVKINEL HHCCCHHEEEEHHHH	49.82	23000965
200	Ubiquitination	RTRKKIVKINELHEK CCHHEEEEHHHHHHH	43.20	29967540
207	Ubiquitination	KINELHEKGSKLCIY EHHHHHHHCCEEEEE	58.71	29967540
209	Phosphorylation	NELHEKGSKLCIYAL HHHHHHCCEEEEEEE	33.26	26270265
211	Ubiquitination	LHEKGSKLCIYALKG HHHHCCEEEEEEECC	1.99	29967540
222	Ubiquitination	ALKGETIEGALCKDG EECCCEEECEECCCC	45.92	29967540
227	Ubiquitination	TIEGALCKDGRFRSD EEECEECCCCCCCCC	65.16	23000965
241	Ubiquitination	DIGEFEWKLKEGHKK CHHCEEEEECHHCHH	42.35	29967540
247	Ubiquitination	WKLKEGHKKIYGKQS EEECHHCHHHCCCCH	52.29	29967540
252	Ubiquitination	GHKKIYGKQSMVDEV HCHHHCCCCHHHHHH	23.41	29967540
254	Phosphorylation	KKIYGKQSMVDEVSG HHHCCCCHHHHHHCC	25.02	30631047
254	Ubiquitination	KKIYGKQSMVDEVSG HHHCCCCHHHHHHCC	25.02	29967540
270	Methylation	VLEMDISKKKALQQK EEEEECCHHHHHHHH	59.64	-
272	Ubiquitination	EMDISKKKALQQKDI EEECCHHHHHHHHHH	59.05	29967540
273	Ubiquitination	MDISKKKALQQKDIH EECCHHHHHHHHHHH	21.34	29967540
277	Ubiquitination	KKKALQQKDIHKKIK HHHHHHHHHHHHHHH	45.77	29967540
284	Ubiquitination	KDIHKKIKQNESATD HHHHHHHHCCCCCCC	56.82	29967540
284	Sumoylation	KDIHKKIKQNESATD HHHHHHHHCCCCCCC	56.82	28112733
288	Phosphorylation	KKIKQNESATDEINH HHHHCCCCCCCCCCH	43.98	27422710
302	Ubiquitination	HQSLIQSKKKVHKPK HHHHHHHHCCCCCCC	39.99	29967540
303	Ubiquitination	QSLIQSKKKVHKPKK HHHHHHHCCCCCCCC	66.33	29967540
305	Ubiquitination	LIQSKKKVHKPKKDG HHHHHCCCCCCCCCC	10.88	32015554
335	Ubiquitination	QDLSHYIKDKTRQTI HHHHHHHCCCCCCCC	46.11	32015554
348	Phosphorylation	TIPRIRNYYFCSLPR CCCHHHHEEECCCCH	6.51	21945579
349	Phosphorylation	IPRIRNYYFCSLPRK CCHHHHEEECCCCHH	11.14	21945579
352	Phosphorylation	IRNYYFCSLPRKYRQ HHHEEECCCCHHHHH	31.35	21945579
352	Ubiquitination	IRNYYFCSLPRKYRQ HHHEEECCCCHHHHH	31.35	23000965
352 (in isoform 2)	Ubiquitination	-	31.35	21890473
357	Phosphorylation	FCSLPRKYRQINSQV ECCCCHHHHHHCHHH	14.72	-
359	Ubiquitination	SLPRKYRQINSQVRR CCCHHHHHHCHHHHC	35.80	32015554
376	Ubiquitination	HLGRRYAINLDVQKE CCCCCEEECHHHHHH	3.79	29967540
382 (in isoform 1)	Ubiquitination	-	49.30	21890473
382	Ubiquitination	AINLDVQKEAINLLK EECHHHHHHHHHHHH	49.30	23000965
389	Ubiquitination	KEAINLLKNYQTLNE HHHHHHHHHHHHHHH	57.69	32015554
393	Phosphorylation	NLLKNYQTLNEAIMH HHHHHHHHHHHHHHH	22.61	28842319
399 (in isoform 2)	Ubiquitination	-	1.76	21890473
399	Ubiquitination	QTLNEAIMHQYPNFK HHHHHHHHHHCCCHH	1.76	21890473
405	Ubiquitination	IMHQYPNFKEEAQWV HHHHCCCHHHHHHHH	10.21	23000965
406	Ubiquitination	MHQYPNFKEEAQWVR HHHCCCHHHHHHHHH	62.37	29967540
426	Phosphorylation	EQKRMNLSPAKQFNI HHHHCCCCHHHHCCE	20.15	21815630
429 (in isoform 1)	Ubiquitination	-	59.82	21890473
429	Ubiquitination	RMNLSPAKQFNIYKK HCCCCHHHHCCEEEC	59.82	23000965
435	Ubiquitination	AKQFNIYKKDFGKMT HHHCCEEECCCCCCC	41.91	23000965
519	Ubiquitination	CAKVTFTYTEFCPTP HEEEEEEEEEECCCC	10.48	29967540
539	Phosphorylation	IEPWLKVSNENLDYA CCCEEEECCCCCCEE	36.52	21406692
545	Phosphorylation	VSNENLDYAILKLKE ECCCCCCEEEEEEHH	9.94	21406692
549	Ubiquitination	NLDYAILKLKENGNA CCCEEEEEEHHCCCC	51.94	29967540
575	Phosphorylation	QPSTGLIYLIGHPEG CCCCEEEEEECCCCC	9.41	-
585	Ubiquitination	GHPEGQIKKIDGCTV CCCCCCEEECCCCEE	35.47	-
586	Ubiquitination	HPEGQIKKIDGCTVI CCCCCEEECCCCEEE	47.89	-
673	Ubiquitination	TFGLFYQRGFNVHAL ECEEHHHCCCCHHHH	40.05	29967540
679	Ubiquitination	QRGFNVHALIEFGYS HCCCCHHHHHCCCCC	13.12	29967540
702	Phosphorylation	KKTNESLYKSLNDEK HHHCHHHHHHCCHHH	14.07	-
703	Ubiquitination	KTNESLYKSLNDEKL HHCHHHHHHCCHHHH	54.48	29967540
709	Ubiquitination	YKSLNDEKLETYDEE HHHCCHHHHHCHHHH	55.26	29967540
712	Phosphorylation	LNDEKLETYDEEKGK CCHHHHHCHHHHCCC	46.86	23403867
713	Phosphorylation	NDEKLETYDEEKGKQ CHHHHHCHHHHCCCC	16.39	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F111B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F111B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F111B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of F111B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615704: Poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.