ASCC3_MOUSE - dbPTM
ASCC3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASCC3_MOUSE
UniProt AC E9PZJ8
Protein Name Activating signal cointegrator 1 complex subunit 3
Gene Name Ascc3
Organism Mus musculus (Mouse).
Sequence Length 2198
Subcellular Localization Nucleus .
Protein Description 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation (By similarity)..
Protein Sequence MALPRLTGALRSFSNVTKQDNYNEEVADLKLKRSKLHEQVLDFGLTWKKIVKFLNEKLEKNKMQNINEDLKDILQAAKQIVGTDNGREAIESGAAFLFMTFHMTDSVGYMETKAIRQTFGPFPSSSATSACNATNRIISHFSQDDLTAFVQMAENPCNDRVVFGKNLAFSFDMYDLDHFDELPINGESQKTISLDYKKFLNEQFQEPYTPELKPVEKTNGSLLWCEVEKYLNATLKEMTEAARVEDLCCTLYDMLASAKSGDELQDELFELLGPEGLDLIEKLLQNRITIVDRFLNSSSDHKFQVLQDSCKKILGENSKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDGEVSGEGVLPFDPKELRIQREHALLNARNAPILGRQRDVEFEKIRYPHVYDSQAQARETSAFIAGAKMILPEGIQRENTKLYEEVRIPYGEPMPVGFEEKPVYIKDLDEVGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTILHEIRQHFHQGVIKKNEFKIVYVAPMKALAAEMTNYFSKRLEPLGIVVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVKLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFYFDGRFRPVPLGQTFLGIKSTNKMQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNSGQISCFLPTEGPEYGHALKQVQKSRNKQVRELFSDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVVIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLSLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEAVRWMSYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLLIEVGQKLDKAKMIRFEERTGYFSSTDLGRTASHFYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDALLNNFCELSAPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSVLPPHILTRLEEKNLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVTMEASIQPITRTVLRVSLNIHPDFSWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVINKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKIRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRSYVQQVNILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEQEMDNIIGTVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDAMDYITWTYFFRRLIMNPSYYSLGDVSQDSINKFLSHLIGQSLVELELSHCIEVGEDNRTIEPLTCGRIASYYYLKHKTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHTNNELAKCLPIELNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAASQGWLVTVLNITHLIQMVIQGRWLKDSSLLTIPNIEQHHLHLFRKWKPPVKSSHAKCRTSIECLPELIHACEGKDHVFSSMVEKELQPAKTKQAWNFLSRLPVINVGISVKGSWDDLVEGHNELSISTLTADKRDENKWIKLHADQEYVLQVSLQRVHFGLPKGKHENHAVTPRFPKLKDEGWFLILGEVDKRELMAVKRVGFVRTHHDASISFFTPETPGRYIFTLYLMSDCYLGLDQQYDIYLNVIKANISTKDSDVFTDLSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationRLTGALRSFSNVTKQ
HHHHHHHHHCCCCCC		33.60-
18UbiquitinationRSFSNVTKQDNYNEE
HHHCCCCCCCCCCHH		51.9122790023
30AcetylationNEEVADLKLKRSKLH
CHHHHHHHHCHHHHH		53.1323236377
57AcetylationIVKFLNEKLEKNKMQ
HHHHHHHHHHHHCCC		61.9515603221
60AcetylationFLNEKLEKNKMQNIN
HHHHHHHHHCCCCCC		72.7615603229
62AcetylationNEKLEKNKMQNINED
HHHHHHHCCCCCCHH		53.5915603237
193PhosphorylationGESQKTISLDYKKFL
CCCCCEEEECHHHHH		22.0329514104
208PhosphorylationNEQFQEPYTPELKPV
HHHCCCCCCCCCCCE		33.8926643407
209PhosphorylationEQFQEPYTPELKPVE
HHCCCCCCCCCCCEE		22.4726745281
213UbiquitinationEPYTPELKPVEKTNG
CCCCCCCCCEECCCC		45.41-
217UbiquitinationPELKPVEKTNGSLLW
CCCCCEECCCCCEEE		47.74-
236UbiquitinationKYLNATLKEMTEAAR
HHHHHHHHHHHHHHH		40.8822790023
297PhosphorylationIVDRFLNSSSDHKFQ
HHHHHHCCCCCCHHH		33.1125338131
298PhosphorylationVDRFLNSSSDHKFQV
HHHHHCCCCCCHHHH		38.4225338131
302UbiquitinationLNSSSDHKFQVLQDS
HCCCCCCHHHHHHHH		42.3427667366
309PhosphorylationKFQVLQDSCKKILGE
HHHHHHHHHHHHHCC		18.1828066266
322PhosphorylationGENSKPNYGCQVTIQ
CCCCCCCCCEEEEEC		28.0129514104
361PhosphorylationAGEDGEVSGEGVLPF
CCCCCCCCCCCCCCC		27.1630635358
375UbiquitinationFDPKELRIQREHALL
CCHHHHHHHHHHHHH		7.6627667366
400UbiquitinationQRDVEFEKIRYPHVY
CCCCCCEECCCCCCC		37.4922790023
424UbiquitinationSAFIAGAKMILPEGI
HHHHHHCHHHCCCCH		26.0922790023
457UbiquitinationMPVGFEEKPVYIKDL
CCCCCCCCCEEEECH		32.3622790023
460PhosphorylationGFEEKPVYIKDLDEV
CCCCCCEEEECHHHH		15.69-
462UbiquitinationEEKPVYIKDLDEVGQ
CCCCEEEECHHHHHH		34.2522790023
473UbiquitinationEVGQLAFKGMKRLNR
HHHHHHHHHHHHHHH		53.1122790023
566PhosphorylationGIVVKELTGDMQLSK
CEEEEECCCCCCCCH		32.02-
573MalonylationTGDMQLSKSEILRTQ
CCCCCCCHHHHHHHC		61.7826320211
573AcetylationTGDMQLSKSEILRTQ
CCCCCCCHHHHHHHC		61.7823806337
584PhosphorylationLRTQMLVTTPEKWDV
HHHCCEEECHHHCCC		32.4522871156
585PhosphorylationRTQMLVTTPEKWDVV
HHCCEEECHHHCCCC		23.2122871156
627PhosphorylationDRGPVLESIVARTLR
CCCHHHHHHHHHHHH		20.4325159016
706PhosphorylationNNMDEVCYESVLKQV
CCHHHHHHHHHHHHH		19.2029899451
708PhosphorylationMDEVCYESVLKQVKA
HHHHHHHHHHHHHHC		13.2829899451
762UbiquitinationPEYGHALKQVQKSRN
HHHHHHHHHHHHHCC		49.5622790023
766AcetylationHALKQVQKSRNKQVR
HHHHHHHHHCCHHHH		53.1522733758
770AcetylationQVQKSRNKQVRELFS
HHHHHCCHHHHHHHH		49.4022733758
939UbiquitinationLAYGISHKAYQIDPT
CCCCCCCCCEECCHH		41.8322790023
1105PhosphorylationALRKRWPTMTYRLLN
HHHHCCCHHHHHHHH		18.3828576409
1145AcetylationILTRLEEKNLTVDKL
HHHHHHHCCCCHHHH		48.1323806337
1145MalonylationILTRLEEKNLTVDKL
HHHHHHHCCCCHHHH		48.1326320211
1383UbiquitinationAVYIAPLKALVRERM
CEEEHHHHHHHHHHC		38.3222790023
1404UbiquitinationIEEKLGKKVIELTGD
HHHHHCCCEEEECCC		46.8022790023
1446UbiquitinationWQNRSYVQQVNILII
HCCCHHHHEEEEEEE		33.0227667366
1544UbiquitinationPRMASMNKPAFQAIR
CCHHHCCCHHHHHHH		29.1322790023
2025UbiquitinationELQPAKTKQAWNFLS
HHCCCCCHHHHHHHH		36.9922790023
2194PhosphorylationTKDSDVFTDLSV---
CCCCCCCCCCCC---		35.5628066266
2197PhosphorylationSDVFTDLSV------
CCCCCCCCC------		28.7026824392
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASCC3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASCC3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASCC3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ASCC3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASCC3_MOUSE

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Related Literatures of Post-Translational Modification

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