RHPN2_MOUSE - dbPTM
RHPN2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHPN2_MOUSE
UniProt AC Q8BWR8
Protein Name Rhophilin-2
Gene Name Rhpn2
Organism Mus musculus (Mouse).
Sequence Length 686
Subcellular Localization Cytoplasm, perinuclear region.
Protein Description Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity)..
Protein Sequence MTDTLLPAAPQPLEKEGDDYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNQKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQGTEEAFTIPLIPLGLKETKEVDFSIVFKDFILEHYSEDSYLYEDDIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFVESRFFPPTRHMGLLFTWYDSFTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQAGLESAVDAFQRAAGVLNYLKETFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKVCLPGIQNEFFVLVKVAQEAAKVAEAYRQLHAAMSQEPVKENIPYSWASVAYVKAYHYGALAHYFAATLLIDHQLKPGADEDHQEKCLSQLYDRMPEGMTPLATLKNAGQRVLLGKGHLHRAIGFHEESLREANLCKKLRDIQVLRDVLSAAHQRTQLKHTQHREDDDLLNLIDAPDVLPKTEREVKITFPDFSKVTVTDFFQKLGPLSVFSASKRWSPPRGIHFTVEEGDLGFTLRGNTPVQVHFLDPHCSASLAGAKEGDYIVSIQGVDCKWLTVSEVMKLLKSFGGEEVEMKVVSLLDSTSSMHNKCATYSVGMQKTYSMICLSMDDDDKADKTKKISKKLSFLSWGTSKNRQKSASTLCLPEVGLARSQNKKKLPTPFSLLNSDSSLY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationLEKEGDDYFRKGCNP
CHHCCCCHHHCCCCH		15.2629514104
31PhosphorylationGCNPLAQTGRSKLQN
CCCHHHHHCHHHHHH		29.0227087446
88UbiquitinationNSDLQMLKEELEGLN
HHHHHHHHHHHCCCC		43.74-
238PhosphorylationGTRCNRQTQAGLESA
HHHCCHHHHHHHHHH		19.7028059163
258PhosphorylationRAAGVLNYLKETFTH
HHHHHHHHHHHHCCC		18.2628059163
321PhosphorylationAAKVAEAYRQLHAAM
HHHHHHHHHHHHHHH		7.1525367039
329PhosphorylationRQLHAAMSQEPVKEN
HHHHHHHCCCCCHHC		27.0225367039
339PhosphorylationPVKENIPYSWASVAY
CCHHCCCCCHHHHHH		17.0425367039
340PhosphorylationVKENIPYSWASVAYV
CHHCCCCCHHHHHHH		15.7125367039
343PhosphorylationNIPYSWASVAYVKAY
CCCCCHHHHHHHHHH		10.8725367039
346PhosphorylationYSWASVAYVKAYHYG
CCHHHHHHHHHHHHH		10.5925367039
576UbiquitinationLTVSEVMKLLKSFGG
EEHHHHHHHHHHCCC		56.7122790023
592PhosphorylationEVEMKVVSLLDSTSS
EEEEEEEEHHHCCCC		26.6329472430
596PhosphorylationKVVSLLDSTSSMHNK
EEEEHHHCCCCHHCC		30.1129472430
597PhosphorylationVVSLLDSTSSMHNKC
EEEHHHCCCCHHCCC		25.2029472430
598PhosphorylationVSLLDSTSSMHNKCA
EEHHHCCCCHHCCCC		29.6229472430
599PhosphorylationSLLDSTSSMHNKCAT
EHHHCCCCHHCCCCC		24.9329472430
606PhosphorylationSMHNKCATYSVGMQK
CHHCCCCCCCCCCCC		26.2921659605
607PhosphorylationMHNKCATYSVGMQKT
HHCCCCCCCCCCCCE		5.2629472430
608PhosphorylationHNKCATYSVGMQKTY
HCCCCCCCCCCCCEE		14.0829472430
614PhosphorylationYSVGMQKTYSMICLS
CCCCCCCEEEEEEEE		12.1621082442
615PhosphorylationSVGMQKTYSMICLSM
CCCCCCEEEEEEEEC		11.8621082442
616PhosphorylationVGMQKTYSMICLSMD
CCCCCEEEEEEEECC		13.6025521595
636AcetylationDKTKKISKKLSFLSW
HHHHHHHHHHHHHHC		62.297714187
637AcetylationKTKKISKKLSFLSWG
HHHHHHHHHHHHHCC		42.447714197
639PhosphorylationKKISKKLSFLSWGTS
HHHHHHHHHHHCCCC		32.7826239621
642PhosphorylationSKKLSFLSWGTSKNR
HHHHHHHHCCCCCCC		22.8121082442
645PhosphorylationLSFLSWGTSKNRQKS
HHHHHCCCCCCCCCC		30.2122817900
646PhosphorylationSFLSWGTSKNRQKSA
HHHHCCCCCCCCCCC		24.8021743459
652PhosphorylationTSKNRQKSASTLCLP
CCCCCCCCCHHCCCC		21.0727087446
654PhosphorylationKNRQKSASTLCLPEV
CCCCCCCHHCCCCHH		29.0725521595
655PhosphorylationNRQKSASTLCLPEVG
CCCCCCHHCCCCHHH		22.6227087446
677PhosphorylationKKLPTPFSLLNSDSS
CCCCCCHHHHCCCCC		32.9026643407
681PhosphorylationTPFSLLNSDSSLY--
CCHHHHCCCCCCC--		38.5526643407
683PhosphorylationFSLLNSDSSLY----
HHHHCCCCCCC----		23.2826643407
684PhosphorylationSLLNSDSSLY-----
HHHCCCCCCC-----		36.3626643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHPN2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHPN2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHPN2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RHPN2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHPN2_MOUSE

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Related Literatures of Post-Translational Modification

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