dbPTM

SVIL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SVIL_MOUSE
UniProt AC	Q8K4L3
Protein Name	Supervillin
Gene Name	Svil
Organism	Mus musculus (Mouse).
Sequence Length	2170
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, invadopodium . Cell projection, podosome . Midbody . Cleavage furrow . Tightly associated with both actin filaments and plasma membranes.
Protein Description	Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function.; Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity)..
Protein Sequence	MKRKERIARRLEGIENDSQPILLQSCTGLVTHRLLEEDTPRYMRATDPASPHIGRSKEEEDTPGSSLEKQTPSKYCIETSGIHSSGSMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYAKSRKDPDVTERRGKSDKQEEQSKDANSRHSRTESGPRTSLVASQDCTPLGSNMSDQEQLLNVENQRRVQDPPLGEDGSSAFFSERSISFPEVPRSPKQIPSSPLQQPASPNHPGDSPLPTEARASTGKPTHEWFLQRDSEGDTPSLINWPSRVKVREKLVKEESARSSPELTSESLTQRRQQPAPAHFLPIQSESSTFDRVTSKAVSSLQPSQSGVLPTDPVHAIKLVTMDTPESTSEFSWVGSATPKVIKSTTLKILEGGSRDAPVLHICESKAEDWLSPEPLERSPKSLLTSEDDRLVRGHKDPSGNKDLDKAIICSIDVESERERQVQHLPTQRTGRSEMLLYVQSGPVSQDATLTSHTKEASPKKRKVLARSLSDYTGPPQLQVPRHKDEAPSQELELQSSRAEGPGAEASVLDTRVSVAQLRNIFMESTRASKKPELQSRVERSAEGIGLPMERERGSRKPRRYLSPGESRKTSERFRTQPITSAERKESDRYPSGSEIPVVEDEEKVDERAKLSVAAKRLLFREMEKSFDEHTVPKRHSRNAAVEQRLRRLQDRSHTQPITTEEVVIAATEPIPASCSGVTHPVTARLPSPTVARSSVQPARLQASAHQKALARDQANEGRESAEPGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDVRQRRMNARYQTQPVTLGEVEQVQSGKLISFSPTVNTSVSIMASAVAPTYAGDLRKLSVDNNTSATDYKSPPAENSDSPVRSILKPQAWRPLVEHSGSKGMPGESGKTESKNALTVAAEDSGVQTRGAFEEEEEPSYPILGRVREGDGQKEPKHVVLRRGSLELGNPSAAHLGDELKEVSTAKSSLQENLDLKDKQASEENTDVETVMRKFSLKEFGETTSEQTEVAARKASVQMATPGAWKQQESSEQLAEKLFKNPCAMFASGEVKVPVGDSFLDSPSKTMSIKERLALLKKSGEEDWKNRLIRKQEYGKATGGLHTQEVEQSLKKKRVTESRESQMTIEERKHLITVREEAWKTKGRGAANDSTQFTVAGRMVKKGLASPTSITPISSPLCSKSRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVAGIQETVLTVTGKSVKEVMKLDDDETFAKFYRSVDHSIPRSPVELEEDFDVIFDPYAPKLTSSVAEHKRQVRPKRRVQASKNPLKLLAARDDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASRENFSNINLRSVNLMEQNSNNSAMPYKKLMLLQIKGRRHVQTRLVEPRASSLNSGDCFLLLSPQYCFLWVGEFSNVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYETAIIETNCVYRLTDDKLVPDDDYWGKIPKCSLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRVTEHNETILFKEKFLDWTELKRPTEKNSGEVVQQKDDPRADVKPYDVTRMVATPQITAGTILDGVNVGRGYGLVEGDDRRQFEIATVSVDVWHILEFDYSRLPRQSIGQFHEGDAYVVKWKYMASTAVGSRQKGEHLVRVAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPMEGNLLEVACHCSSLRSRTSMVVLNINKALIYLWHGCKAQGHTKEVGRTAANKIKEECPLEAGLHSSSNVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFSATEFVYPAQAPSAVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPTENKITGSARIRWASDRKSAMETVLQYCRGKNLKRPPPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMSRDEFNALPTWKQVNLKKSKGLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	LEEDTPRYMRATDPA HCCCCCCCCCCCCCC	7.67	29514104
46	Phosphorylation	TPRYMRATDPASPHI CCCCCCCCCCCCCCC	31.95	28833060
50	Phosphorylation	MRATDPASPHIGRSK CCCCCCCCCCCCCCC	23.54	26824392
56	Phosphorylation	ASPHIGRSKEEEDTP CCCCCCCCCCCCCCC	38.92	27742792
79	Phosphorylation	PSKYCIETSGIHSSG CCCEEEECCCCCCCC	16.61	27742792
80	Phosphorylation	SKYCIETSGIHSSGS CCEEEECCCCCCCCC	23.98	27742792
84	Phosphorylation	IETSGIHSSGSMDTH EECCCCCCCCCCCCC	34.18	27742792
85	Phosphorylation	ETSGIHSSGSMDTHS ECCCCCCCCCCCCCC	22.26	27742792
87	Phosphorylation	SGIHSSGSMDTHSLE CCCCCCCCCCCCCHH	18.55	27742792
90	Phosphorylation	HSSGSMDTHSLESKA CCCCCCCCCCHHHHH	12.53	27742792
92	Phosphorylation	SGSMDTHSLESKAER CCCCCCCCHHHHHHH	35.60	27742792
95	Phosphorylation	MDTHSLESKAERIAR CCCCCHHHHHHHHHH	42.32	27742792
118	Phosphorylation	LAEKYGLTLDPEADS HHHHHCCCCCHHHCH	25.42	29514104
125	Phosphorylation	TLDPEADSEYLSRYA CCCHHHCHHHHHHHH	34.88	22817900
164	Phosphorylation	ANSRHSRTESGPRTS CHHHHCCCCCCCCCE	37.20	26160508
166	Phosphorylation	SRHSRTESGPRTSLV HHHCCCCCCCCCEEE	54.18	26160508
170	Phosphorylation	RTESGPRTSLVASQD CCCCCCCCEEEECCC	29.55	26160508
171	Phosphorylation	TESGPRTSLVASQDC CCCCCCCEEEECCCC	23.33	26160508
175	Phosphorylation	PRTSLVASQDCTPLG CCCEEEECCCCCCCC	21.05	26160508
179	Phosphorylation	LVASQDCTPLGSNMS EEECCCCCCCCCCCC	29.82	29472430
183	Phosphorylation	QDCTPLGSNMSDQEQ CCCCCCCCCCCHHHH	36.72	22802335
211	Phosphorylation	PLGEDGSSAFFSERS CCCCCCCCCCCCCCC	34.33	29514104
218	Phosphorylation	SAFFSERSISFPEVP CCCCCCCCCCCCCCC	20.66	27087446
220	Phosphorylation	FFSERSISFPEVPRS CCCCCCCCCCCCCCC	35.68	27087446
227	Phosphorylation	SFPEVPRSPKQIPSS CCCCCCCCCCCCCCC	30.31	27087446
233	Phosphorylation	RSPKQIPSSPLQQPA CCCCCCCCCCCCCCC	46.33	27087446
233 (in isoform 3)	Phosphorylation	-	46.33	25293948
234	Phosphorylation	SPKQIPSSPLQQPAS CCCCCCCCCCCCCCC	25.03	27087446
234 (in isoform 3)	Phosphorylation	-	25.03	25293948
241	Phosphorylation	SPLQQPASPNHPGDS CCCCCCCCCCCCCCC	32.68	27087446
241 (in isoform 3)	Phosphorylation	-	32.68	25293948
248	Phosphorylation	SPNHPGDSPLPTEAR CCCCCCCCCCCCCHH	33.96	27087446
248 (in isoform 3)	Phosphorylation	-	33.96	26824392
252	Phosphorylation	PGDSPLPTEARASTG CCCCCCCCCHHHCCC	50.38	27087446
252 (in isoform 3)	Phosphorylation	-	50.38	25293948
258	Phosphorylation	PTEARASTGKPTHEW CCCHHHCCCCCCCCE	48.52	23684622
258	Phosphorylation	PTEARASTGKPTHEW CCCHHHCCCCCCCCE	48.52	23684622
258 (in isoform 3)	Phosphorylation	-	48.52	26239621
260	Phosphorylation	EARASTGKPTHEWFL CHHHCCCCCCCCEEC	47.00	21183079
260	Phosphorylation	EARASTGKPTHEWFL CHHHCCCCCCCCEEC	47.00	21183079
260 (in isoform 3)	Phosphorylation	-	47.00	25521595
262	Phosphorylation	RASTGKPTHEWFLQR HHCCCCCCCCEECCC	35.59	23684622
262	Phosphorylation	RASTGKPTHEWFLQR HHCCCCCCCCEECCC	35.59	23684622
262 (in isoform 3)	Phosphorylation	-	35.59	25521595
271	Phosphorylation	EWFLQRDSEGDTPSL CEECCCCCCCCCCHH	45.74	27742792
277	Phosphorylation	DSEGDTPSLINWPSR CCCCCCCHHHCCCCC	43.93	23737553
296	Phosphorylation	EKLVKEESARSSPEL HHHHHHHHHCCCCCC	30.03	23737553
299	Phosphorylation	VKEESARSSPELTSE HHHHHHCCCCCCCHH	50.38	24899341
300	Phosphorylation	KEESARSSPELTSES HHHHHCCCCCCCHHH	19.48	24899341
321 (in isoform 3)	Phosphorylation	-	2.34	26745281
323 (in isoform 3)	Phosphorylation	-	8.39	26745281
327 (in isoform 3)	Phosphorylation	-	39.67	26745281
328 (in isoform 3)	Phosphorylation	-	29.10	26745281
346	Phosphorylation	SSLQPSQSGVLPTDP HHCCCCCCCCCCCCC	34.90	28464351
361	Phosphorylation	VHAIKLVTMDTPEST CCEEEEEECCCCCCC	21.55	23737553
364	Phosphorylation	IKLVTMDTPESTSEF EEEEECCCCCCCCCC	20.38	23737553
367	Phosphorylation	VTMDTPESTSEFSWV EECCCCCCCCCCCCC	38.14	23737553
368	Phosphorylation	TMDTPESTSEFSWVG ECCCCCCCCCCCCCC	30.52	23737553
369	Phosphorylation	MDTPESTSEFSWVGS CCCCCCCCCCCCCCC	46.02	23737553
372	Phosphorylation	PESTSEFSWVGSATP CCCCCCCCCCCCCCC	19.46	23737553
384	Phosphorylation	ATPKVIKSTTLKILE CCCCEEECCEEEECC	18.59	22871156
385	Phosphorylation	TPKVIKSTTLKILEG CCCEEECCEEEECCC	31.01	22871156
412	Phosphorylation	SKAEDWLSPEPLERS CCCCCCCCCCCCCCC	23.98	24899341
419	Phosphorylation	SPEPLERSPKSLLTS CCCCCCCCCCCCCCC	27.57	22817900
473	Phosphorylation	PTQRTGRSEMLLYVQ CCCCCCCCCEEEEEE	28.80	26026062
478	Phosphorylation	GRSEMLLYVQSGPVS CCCCEEEEEECCCCC	7.77	26026062
481	Phosphorylation	EMLLYVQSGPVSQDA CEEEEEECCCCCCCC	34.71	26026062
494	Phosphorylation	DATLTSHTKEASPKK CCCCCCCCCCCCHHH	30.28	22871156
508	Phosphorylation	KRKVLARSLSDYTGP HHHHHHHHHHCCCCC	26.98	27742792
510	Phosphorylation	KVLARSLSDYTGPPQ HHHHHHHHCCCCCCC	29.80	26824392
512	Phosphorylation	LARSLSDYTGPPQLQ HHHHHHCCCCCCCCC	15.38	24899341
513	Phosphorylation	ARSLSDYTGPPQLQV HHHHHCCCCCCCCCC	48.48	27742792
529	Phosphorylation	RHKDEAPSQELELQS CCCCCCCCHHHHHHH	43.25	27742792
547	Phosphorylation	EGPGAEASVLDTRVS CCCCCCHHHHCHHCH	18.08	28464351
580	Methylation	ELQSRVERSAEGIGL HHHHHHHHHHCCCCC	38.01	18967475
581	Phosphorylation	LQSRVERSAEGIGLP HHHHHHHHHCCCCCC	19.71	22802335
603	Phosphorylation	RKPRRYLSPGESRKT CCCCCCCCCCCCCCC	23.17	24899341
607	Phosphorylation	RYLSPGESRKTSERF CCCCCCCCCCCCHHH	45.02	27742792
616	Phosphorylation	KTSERFRTQPITSAE CCCHHHHCCCCCHHH	35.67	26824392
630	Phosphorylation	ERKESDRYPSGSEIP HHHHHCCCCCCCCCC	13.52	17203969
632	Phosphorylation	KESDRYPSGSEIPVV HHHCCCCCCCCCCCC	46.12	25521595
634	Phosphorylation	SDRYPSGSEIPVVED HCCCCCCCCCCCCCC	36.37	25521595
666	Phosphorylation	LFREMEKSFDEHTVP HHHHHHHHCCCCCCC	25.32	26824392
671	Phosphorylation	EKSFDEHTVPKRHSR HHHCCCCCCCCHHHH	36.13	27742792
677	Phosphorylation	HTVPKRHSRNAAVEQ CCCCCHHHHHHHHHH	31.12	29514104
695	Phosphorylation	RLQDRSHTQPITTEE HHHCCCCCCCCCCCE	36.97	21183079
700	Phosphorylation	SHTQPITTEEVVIAA CCCCCCCCCEEEEEE	30.76	-
728	Phosphorylation	PVTARLPSPTVARSS CCEECCCCCCCCCCC	37.48	23737553
734	Phosphorylation	PSPTVARSSVQPARL CCCCCCCCCCCHHHH	25.73	24719451
735	Phosphorylation	SPTVARSSVQPARLQ CCCCCCCCCCHHHHH	21.15	24719451
761	Phosphorylation	QANEGRESAEPGEPD HHHCCCCCCCCCCCC	36.25	25521595
769	Phosphorylation	AEPGEPDSSTLSLAE CCCCCCCHHHHHHHH	35.62	27742792
770	Phosphorylation	EPGEPDSSTLSLAEK CCCCCCHHHHHHHHH	40.52	27742792
785	Phosphorylation	LALFNKLSQPVSKAI HHHHHHHCCCHHHHH	33.76	29514104
809	Phosphorylation	QRRMNARYQTQPVTL HHHHHCCCCCCCEEC	17.32	25521595
811	Phosphorylation	RMNARYQTQPVTLGE HHHCCCCCCCEECCC	26.38	25521595
815	Phosphorylation	RYQTQPVTLGEVEQV CCCCCCEECCCEEEE	35.41	25619855
829	Phosphorylation	VQSGKLISFSPTVNT EECCCEEEEECCCCC	30.06	26745281
831	Phosphorylation	SGKLISFSPTVNTSV CCCEEEEECCCCCCH	16.93	26745281
833	Phosphorylation	KLISFSPTVNTSVSI CEEEEECCCCCCHHH	25.78	26745281
836	Phosphorylation	SFSPTVNTSVSIMAS EEECCCCCCHHHHHH	26.60	26745281
837	Phosphorylation	FSPTVNTSVSIMASA EECCCCCCHHHHHHC	14.52	26745281
839	Phosphorylation	PTVNTSVSIMASAVA CCCCCCHHHHHHCCC	13.35	26745281
843	Phosphorylation	TSVSIMASAVAPTYA CCHHHHHHCCCCCCC	13.09	26643407
848	Phosphorylation	MASAVAPTYAGDLRK HHHCCCCCCCCCCEE	19.10	26643407
849	Phosphorylation	ASAVAPTYAGDLRKL HHCCCCCCCCCCEEE	13.92	26643407
857	Phosphorylation	AGDLRKLSVDNNTSA CCCCEEEEECCCCCC	30.38	27087446
862	Phosphorylation	KLSVDNNTSATDYKS EEEECCCCCCCCCCC	26.45	27742792
863	Phosphorylation	LSVDNNTSATDYKSP EEECCCCCCCCCCCC	31.15	27742792
865	Phosphorylation	VDNNTSATDYKSPPA ECCCCCCCCCCCCCC	39.36	22942356
867	Phosphorylation	NNTSATDYKSPPAEN CCCCCCCCCCCCCCC	14.71	25619855
869	Phosphorylation	TSATDYKSPPAENSD CCCCCCCCCCCCCCC	29.86	25619855
875	Phosphorylation	KSPPAENSDSPVRSI CCCCCCCCCCCHHHH	30.85	25619855
877	Phosphorylation	PPAENSDSPVRSILK CCCCCCCCCHHHHCC	25.72	25521595
881	Phosphorylation	NSDSPVRSILKPQAW CCCCCHHHHCCCCCC	32.29	-
920	Phosphorylation	LTVAAEDSGVQTRGA EEEEEHHCCCCCCCC	32.16	22802335
936	Phosphorylation	EEEEEPSYPILGRVR CCCCCCCCCCCCEEE	12.66	-
960	Phosphorylation	HVVLRRGSLELGNPS EEEEECCCEECCCCC	19.50	27087446
967	Phosphorylation	SLELGNPSAAHLGDE CEECCCCCHHHHHHH	41.93	27742792
979	Phosphorylation	GDELKEVSTAKSSLQ HHHHHHHHHHHHHHH	24.60	24068923
980	Phosphorylation	DELKEVSTAKSSLQE HHHHHHHHHHHHHHH	43.19	24068923
983	Phosphorylation	KEVSTAKSSLQENLD HHHHHHHHHHHHCCC	33.54	24899341
984	Phosphorylation	EVSTAKSSLQENLDL HHHHHHHHHHHCCCC	33.11	28464351
997	Phosphorylation	DLKDKQASEENTDVE CCCHHHHHHCCCCHH	42.84	27742792
1001	Phosphorylation	KQASEENTDVETVMR HHHHHCCCCHHHHHH	44.71	27742792
1011	Phosphorylation	ETVMRKFSLKEFGET HHHHHHHCHHHHCCC	41.38	26824392
1018	Phosphorylation	SLKEFGETTSEQTEV CHHHHCCCCCHHHHH	35.68	28833060
1019	Phosphorylation	LKEFGETTSEQTEVA HHHHCCCCCHHHHHH	26.43	28833060
1020	Phosphorylation	KEFGETTSEQTEVAA HHHCCCCCHHHHHHH	34.82	28833060
1031	Phosphorylation	EVAARKASVQMATPG HHHHHHHHCEECCCC	18.86	25521595
1036	Phosphorylation	KASVQMATPGAWKQQ HHHCEECCCCHHHCC	19.53	27717184
1045	Phosphorylation	GAWKQQESSEQLAEK CHHHCCCCHHHHHHH	34.53	30352176
1046	Phosphorylation	AWKQQESSEQLAEKL HHHCCCCHHHHHHHH	28.71	27742792
1073	Phosphorylation	VKVPVGDSFLDSPSK EEECCCCHHCCCCCC	23.06	29550500
1077	Phosphorylation	VGDSFLDSPSKTMSI CCCHHCCCCCCCCCH	32.97	24068923
1079	Phosphorylation	DSFLDSPSKTMSIKE CHHCCCCCCCCCHHH	44.72	24068923
1113	Phosphorylation	KQEYGKATGGLHTQE HHHHHCCCCCCCHHH	34.96	26643407
1118	Phosphorylation	KATGGLHTQEVEQSL CCCCCCCHHHHHHHH	31.31	26643407
1124	Phosphorylation	HTQEVEQSLKKKRVT CHHHHHHHHHHCCCC	28.75	26643407
1131	Phosphorylation	SLKKKRVTESRESQM HHHHCCCCCCHHHCC	32.07	20495213
1133	Phosphorylation	KKKRVTESRESQMTI HHCCCCCCHHHCCCH	31.79	20495213
1136	Phosphorylation	RVTESRESQMTIEER CCCCCHHHCCCHHHH	24.92	26824392
1159	Methylation	EAWKTKGRGAANDST HHHHCCCCCCCCCCC	32.88	24129315
1165	Phosphorylation	GRGAANDSTQFTVAG CCCCCCCCCCEEEEC	24.74	22802335
1166	Phosphorylation	RGAANDSTQFTVAGR CCCCCCCCCEEEECH	30.48	22802335
1169	Phosphorylation	ANDSTQFTVAGRMVK CCCCCCEEEECHHHH	10.30	22802335
1181	Phosphorylation	MVKKGLASPTSITPI HHHCCCCCCCCCCCC	33.48	26824392
1183	Phosphorylation	KKGLASPTSITPISS HCCCCCCCCCCCCCC	30.20	27742792
1184	Phosphorylation	KGLASPTSITPISSP CCCCCCCCCCCCCCC	28.05	27742792
1186	Phosphorylation	LASPTSITPISSPLC CCCCCCCCCCCCCCC	17.84	27742792
1189	Phosphorylation	PTSITPISSPLCSKS CCCCCCCCCCCCCCC	27.40	27742792
1190	Phosphorylation	TSITPISSPLCSKSR CCCCCCCCCCCCCCC	23.70	27742792
1194	Phosphorylation	PISSPLCSKSRGTTP CCCCCCCCCCCCCCC	41.15	28833060
1196	Phosphorylation	SSPLCSKSRGTTPVS CCCCCCCCCCCCCCC	21.46	22817900
1270	Phosphorylation	TFAKFYRSVDHSIPR HHHHHHHHCCCCCCC	22.10	26239621
1274	Phosphorylation	FYRSVDHSIPRSPVE HHHHCCCCCCCCCCC	29.80	23984901
1278	Phosphorylation	VDHSIPRSPVELEED CCCCCCCCCCCCCCC	28.13	26824392
1299	Phosphorylation	PYAPKLTSSVAEHKR CCCCCCCHHHHHHHH	33.00	-
1300	Phosphorylation	YAPKLTSSVAEHKRQ CCCCCCHHHHHHHHH	21.80	29514104
1346	Phosphorylation	LNVAFMESKRMKVEK HHHHHHHHHCCCEEE	17.49	29514104
1355	Phosphorylation	RMKVEKMSSNSNFSE CCCEEECCCCCCCHH	37.12	23737553
1356	Phosphorylation	MKVEKMSSNSNFSEV CCEEECCCCCCCHHH	40.56	23737553
1358	Phosphorylation	VEKMSSNSNFSEVTL EEECCCCCCCHHHHH	41.00	23737553
1361	Phosphorylation	MSSNSNFSEVTLAGL CCCCCCCHHHHHHHH	35.09	23737553
1364	Phosphorylation	NSNFSEVTLAGLASR CCCCHHHHHHHHHCC	13.57	23737553
1375	Phosphorylation	LASRENFSNINLRSV HHCCCCCCCCCCCHH	48.67	30352176
1453	Phosphorylation	VIEKAKASELATLIQ HHHHHHHHHHHHHHH	32.22	-
1457	Phosphorylation	AKASELATLIQTKRE HHHHHHHHHHHHHHH	36.70	-
1461	Phosphorylation	ELATLIQTKRELGCR HHHHHHHHHHHHCCC	25.69	-
1568	Phosphorylation	VWHGKEVTLAQRKIA EECCCEEEHHHHHHH	19.91	-
1747	Phosphorylation	KWKYMASTAVGSRQK EEEEEEECCCCCCCC	18.80	28059163
1751	Phosphorylation	MASTAVGSRQKGEHL EEECCCCCCCCCCEE	25.57	-
2027	Phosphorylation	TENKITGSARIRWAS CCCCCCCCEEEEECC	13.01	24704852

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SVIL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SVIL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SVIL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SVIL_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SVIL_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-960, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227; SER-666; SER-857AND SER-960, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218; SER-227; SER-632;SER-634 AND SER-1011, AND MASS SPECTROMETRY.	17242355 [Abstract]