dbPTM

GFPT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GFPT1_MOUSE
UniProt AC	P47856
Protein Name	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Gene Name	Gfpt1
Organism	Mus musculus (Mouse).
Sequence Length	697
Subcellular Localization
Protein Description	Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1..
Protein Sequence	MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSTWWGSQAERGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Ubiquitination	EILETLIKGLQRLEY HHHHHHHHHHHHHHH	57.59	22790023
37	Phosphorylation	LEYRGYDSAGVGLDG HHHCCCCCCCCCCCC	20.59	26525534
48	Ubiquitination	GLDGGNDKDWEANAC CCCCCCCCCHHHHHH	69.60	22790023
205	Phosphorylation	AVGTRRGSPLLIGVR CCCCCCCCCEEEEEE	15.57	24759943
243 (in isoform 2)	Phosphorylation	-	55.09	26824392
251	Phosphorylation	RGKDKKGSCGLSRVD CCCCCCCCCCCCCCC	17.56	26643407
255	Phosphorylation	KKGSCGLSRVDSTTC CCCCCCCCCCCCCCE	18.62	26239621
259	Phosphorylation	CGLSRVDSTTCLFPV CCCCCCCCCCEEEEC	23.82	24925903
260	Phosphorylation	GLSRVDSTTCLFPVE CCCCCCCCCEEEECC	19.64	25521595
261	Phosphorylation	LSRVDSTTCLFPVEE CCCCCCCCEEEECCH	15.91	25521595
377	Acetylation	GGLKDHIKEIQRCRR CCHHHHHHHHHHHHH	45.40	23806337
551	Phosphorylation	QKLATELYHQKSVLI HHHHHHHHHCCEEEE	8.93	-
695	Phosphorylation	RNLAKSVTVE----- CCHHCCCCCC-----	26.47	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
259	S	Phosphorylation	Kinase	PRKAA1	Q5EG47	GPS
259	S	Phosphorylation	Kinase	PRKAA2	Q8BRK8	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GFPT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GFPT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GFPT1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GFPT1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, AND MASSSPECTROMETRY.	18630941 [Abstract]