NP1L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NP1L1_MOUSE
• UniProt AC: P28656
• Protein Name: Nucleosome assembly protein 1-like 1
• Gene Name: Nap1l1
• Organism: Mus musculus (Mouse).
• Sequence Length: 391
• Subcellular Localization: Nucleus. Melanosome.
• Protein Description: May be involved in modulating chromatin formation and contribute to regulation of cell proliferation..
• Protein Sequence: MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQNPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFVLEFHFEPNDYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPENGDLDDDAEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADIDNKEQ ------CCCCCHHHH	23.59	-
10	Phosphorylation	DIDNKEQSELDQDLE CCCHHHHHHHHHCCH	41.01	26824392
19	Ubiquitination	LDQDLEDVEEVEEEE HHHCCHHHHHHHHHH	5.02	27667366
27	Phosphorylation	EEVEEEETGEETKIK HHHHHHHCCHHHCHH	53.85	25619855
31	Phosphorylation	EEETGEETKIKARQL HHHCCHHHCHHHHHH	33.49	23649490
32	Ubiquitination	EETGEETKIKARQLT HHCCHHHCHHHHHHH	45.55	-
39	Phosphorylation	KIKARQLTVQMMQNP CHHHHHHHHHHHCCH	10.60	23649490
53	Ubiquitination	PQILAALQERLDGLV HHHHHHHHHHHCCCC	29.10	27667366
62	Phosphorylation	RLDGLVDTPTGYIES HHCCCCCCCCCHHHH	18.44	26824392
64	Phosphorylation	DGLVDTPTGYIESLP CCCCCCCCCHHHHHH	44.72	22942356
66	Phosphorylation	LVDTPTGYIESLPKV CCCCCCCHHHHHHHH	12.18	25777480
69	Phosphorylation	TPTGYIESLPKVVKR CCCCHHHHHHHHHHH	40.17	27180971
72	Ubiquitination	GYIESLPKVVKRRVN CHHHHHHHHHHHHHH	66.02	-
82	Ubiquitination	KRRVNALKNLQVKCA HHHHHHHHHHHHHHH	53.88	27667366
87	Ubiquitination	ALKNLQVKCAQIEAK HHHHHHHHHHHHHHH	15.76	-
88	Glutathionylation	LKNLQVKCAQIEAKF HHHHHHHHHHHHHHH	3.37	24333276
105	Ubiquitination	EVHDLERKYAVLYQP HHHHHHHHHHHHHHH	28.34	-
106	Phosphorylation	VHDLERKYAVLYQPL HHHHHHHHHHHHHHH	14.25	22802335
109	Ubiquitination	LERKYAVLYQPLFDK HHHHHHHHHHHHHHH	2.21	27667366
110	Phosphorylation	ERKYAVLYQPLFDKR HHHHHHHHHHHHHHH	11.07	22802335
116	Ubiquitination	LYQPLFDKRFEIINA HHHHHHHHHHHHHHH	52.21	27667366
116	Acetylation	LYQPLFDKRFEIINA HHHHHHHHHHHHHHH	52.21	23806337
128	Phosphorylation	INAIYEPTEEECEWK HHHHCCCCHHHCCCC	44.05	24759943
132	Glutathionylation	YEPTEEECEWKPDEE CCCCHHHCCCCCCCC	9.52	24333276
135	Ubiquitination	TEEECEWKPDEEDEV CHHHCCCCCCCCCHH	21.94	-
143	Phosphorylation	PDEEDEVSEELKEKA CCCCCHHCHHHHHHH	24.25	21082442
143	Ubiquitination	PDEEDEVSEELKEKA CCCCCHHCHHHHHHH	24.25	27667366
147	Ubiquitination	DEVSEELKEKAKIED CHHCHHHHHHHCCCC	61.52	-
149	Ubiquitination	VSEELKEKAKIEDEK HCHHHHHHHCCCCCC	54.08	-
182	Phosphorylation	FKNVDLLSDMVQEHD HCCCHHHHHHHHHCC	30.84	25338131
194	Acetylation	EHDEPILKHLKDIKV HCCHHHHHHHHHCEE	47.84	23806337
208	Ubiquitination	VKFSDAGQPMSFVLE EEECCCCCCEEEEEE	32.04	27667366
223	Phosphorylation	FHFEPNDYFTNEVLT EECCCCCCCCHHHHH	20.95	-
263	Acetylation	TGCQIDWKKGKNVTL CCCCEEECCCCCEEE	48.15	70385
264	Acetylation	GCQIDWKKGKNVTLK CCCEEECCCCCEEEE	71.51	70389
271	Ubiquitination	KGKNVTLKTIKKKQK CCCCEEEEEHHHHHH	38.55	27667366
298	Ubiquitination	TVSNDSFFNFFAPPE EECCCCCCCCCCCCC	10.11	27667366
359	5-glutamyl polyglycine	DDYDEEGEEADEEGE CCCCCCCHHCCHHCC	53.98	-
359	Formation of an isopeptide bond	DDYDEEGEEADEEGE CCCCCCCHHCCHHCC	53.98	18331838
360	5-glutamyl polyglycine	DYDEEGEEADEEGEE CCCCCCHHCCHHCCC	72.74	-
360	Formation of an isopeptide bond	DYDEEGEEADEEGEE CCCCCCHHCCHHCCC	72.74	18331838
388	Methylation	KDQNPAECKQQ---- CCCCHHHHHCC----	5.39	-
388	Farnesylation	KDQNPAECKQQ---- CCCCHHHHHCC----	5.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NP1L1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NP1L1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NP1L1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NP1L2_MOUSE	Nap1l2	physical	21333655

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-62, AND MASSSPECTROMETRY.
PubMed: 15345747