PESC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PESC_MOUSE
• UniProt AC: Q9EQ61
• Protein Name: Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028}
• Gene Name: Pes1
• Organism: Mus musculus (Mouse).
• Sequence Length: 584
• Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.
• Protein Description: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome..
• Protein Sequence: MGGLEKKKYERGSATNYITRNKARKKLQLSLPDFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIKFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNAVERLKDNKPCYKLDHIVKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFLHYVITARALRKVFLSIKGIYYQAEVLGQPIVWIAPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQSLNLHYPPKLEGQAQAETKISEDTYALDSESSMEKLAALSASLARVVVPAIEEAEADEFPTDGEVTAQEEDRKKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGDVSWDKSLCIGATYDVTDSCITHQIVDRPGQQTPIIGRYYVQPQWVFDCVNARLLLPVAEYFPGMQLPPHLSPFVSEKEGDYIPPEKLKLLALQRGEDPGHLEEEEEEDEDDDNEGDVAAENEEEDVEVESEEEEEEEVHLSALEQHRLEEKKPQVMAGTVKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDDAVRSEKKAKRTRPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	KKKYERGSATNYITR CCCCCCCCCCCHHCH	37.83	29176673
15	Phosphorylation	KYERGSATNYITRNK CCCCCCCCCHHCHHH	30.19	29176673
17	Phosphorylation	ERGSATNYITRNKAR CCCCCCCHHCHHHHH	10.18	29514104
81	Ubiquitination	LHEPIVNKFREYKVF HCCHHHHHHHHHHHH	34.60	-
96	Phosphorylation	VRKLRKAYGKSEWNA HHHHHHHHCCHHHCH	28.28	25338131
98	Acetylation	KLRKAYGKSEWNAVE HHHHHHCCHHHCHHH	32.31	-
99	Phosphorylation	LRKAYGKSEWNAVER HHHHHCCHHHCHHHH	43.40	25338131
269	Phosphorylation	EDTYALDSESSMEKL CCCCCCCCCCHHHHH	39.98	30635358
271	Phosphorylation	TYALDSESSMEKLAA CCCCCCCCHHHHHHH	38.65	30635358
272	Phosphorylation	YALDSESSMEKLAAL CCCCCCCHHHHHHHH	27.23	30635358
280	Phosphorylation	MEKLAALSASLARVV HHHHHHHHHHHHHHH	15.87	-
282	Phosphorylation	KLAALSASLARVVVP HHHHHHHHHHHHHHH	21.13	29176673
301	Phosphorylation	AEADEFPTDGEVTAQ HHHCCCCCCCCCCCC	63.05	23608596
433	Phosphorylation	VSEKEGDYIPPEKLK CCCCCCCCCCHHHHH	26.61	25159016
440	Ubiquitination	YIPPEKLKLLALQRG CCCHHHHHHHHHHCC	53.15	-
482	Phosphorylation	EEDVEVESEEEEEEE HHCCCCCCCHHHHHH	56.32	22802335
493	Phosphorylation	EEEEVHLSALEQHRL HHHHHHHHHHHHHHH	18.87	22802335
546	Ubiquitination	REKYLYQKIMFGKRR HHHHHHHHHHHCHHH	23.68	-
574	Phosphorylation	AHDDAVRSEKKAKRT HHHHHHHHHHHHHHC	47.36	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PESC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PESC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PESC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PESC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.