MK67I_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MK67I_MOUSE
• UniProt AC: Q91VE6
• Protein Name: MKI67 FHA domain-interacting nucleolar phosphoprotein
• Gene Name: Nifk
• Organism: Mus musculus (Mouse).
• Sequence Length: 317
• Subcellular Localization: Nucleus, nucleolus. Chromosome. Localizes to mitotic chromosomes in conjunction with MKI67..
• Protein Sequence: MAGLAGPAKPSLALNPQEDSQFEKALTQIQGRTKKPQQKKKEKLNRGVVYLGHLPSTLSESHIYNYCAQFGDISRFRLSRSKRTGNSKGYAFVEFESEDVAKIVAETMDNYLFGERLLSCKFMPRKKVHKDLFSQRNALFHRPSFPAVKRYNRKRGHLQMLKMEYRFKKKEKLLRKKLAAKGIDYSFPSLVLPKPKNIAVAHRDSEGNQVLPDQKEGLSGEPRRKEKMMKEDISNNIPKKRKRSRRKKSSVDSQGPTPVCTPTFLERRKSQVMEVGGDKDDEIILKLPVPPVKEDTQKTPTSASPGGKRPRKRKSKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGLAGPAK ------CCCCCCCCC	23.00	-
20	Phosphorylation	ALNPQEDSQFEKALT CCCCCCCHHHHHHHH	35.70	26643407
50	Phosphorylation	KLNRGVVYLGHLPST HHCCCEEEECCCCCC	12.45	25293948
56	Phosphorylation	VYLGHLPSTLSESHI EEECCCCCCCCHHHH	48.63	25293948
57	Phosphorylation	YLGHLPSTLSESHIY EECCCCCCCCHHHHH	32.15	25293948
59	Phosphorylation	GHLPSTLSESHIYNY CCCCCCCCHHHHHHH	36.82	25293948
61	Phosphorylation	LPSTLSESHIYNYCA CCCCCCHHHHHHHHH	16.29	25293948
64	Phosphorylation	TLSESHIYNYCAQFG CCCHHHHHHHHHHHC	8.48	25293948
66	Phosphorylation	SESHIYNYCAQFGDI CHHHHHHHHHHHCCE	3.38	25293948
74	Phosphorylation	CAQFGDISRFRLSRS HHHHCCEEEEEEECC	30.06	25293948
116	Methylation	DNYLFGERLLSCKFM HHHHHHHHHHCCCCC	41.11	-
144	Phosphorylation	NALFHRPSFPAVKRY CHHHCCCCCHHHHHH	43.76	28725479
203	Citrullination	KNIAVAHRDSEGNQV CCEEEEEECCCCCEE	39.14	-
203	Citrullination	KNIAVAHRDSEGNQV CCEEEEEECCCCCEE	39.14	24463520
205	Phosphorylation	IAVAHRDSEGNQVLP EEEEEECCCCCEECC	47.57	25619855
219	Phosphorylation	PDQKEGLSGEPRRKE CCCCCCCCCCCHHHH	52.55	-
249	Phosphorylation	KRSRRKKSSVDSQGP HHHHHHHCCCCCCCC	38.33	25619855
250	Phosphorylation	RSRRKKSSVDSQGPT HHHHHHCCCCCCCCC	38.53	25619855
253	Phosphorylation	RKKSSVDSQGPTPVC HHHCCCCCCCCCCCC	34.58	22942356
257	Phosphorylation	SVDSQGPTPVCTPTF CCCCCCCCCCCCHHH	34.87	27149854
261	Phosphorylation	QGPTPVCTPTFLERR CCCCCCCCHHHHHHH	26.12	22942356
263	Phosphorylation	PTPVCTPTFLERRKS CCCCCCHHHHHHHHH	23.77	25619855
267	Methylation	CTPTFLERRKSQVME CCHHHHHHHHHHHEE	54.17	-
268	Methylation	TPTFLERRKSQVMEV CHHHHHHHHHHHEEE	33.33	-
270	Phosphorylation	TFLERRKSQVMEVGG HHHHHHHHHHEEECC	26.62	25521595
296	Phosphorylation	VPPVKEDTQKTPTSA CCCCCCCCCCCCCCC	32.81	28066266
299	Phosphorylation	VKEDTQKTPTSASPG CCCCCCCCCCCCCCC	23.21	25159016
301	Phosphorylation	EDTQKTPTSASPGGK CCCCCCCCCCCCCCC	42.00	25159016
302	Phosphorylation	DTQKTPTSASPGGKR CCCCCCCCCCCCCCC	28.14	25159016
304	Phosphorylation	QKTPTSASPGGKRPR CCCCCCCCCCCCCCC	24.68	27087446
308	Acetylation	TSASPGGKRPRKRKS CCCCCCCCCCCCCCC	66.21	6569827

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MK67I_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MK67I_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MK67I_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MK67I_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.