TANC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TANC1_MOUSE
• UniProt AC: Q0VGY8
• Protein Name: Protein TANC1
• Gene Name: Tanc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1856
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
• Protein Description: May be a scaffold component in the postsynaptic density..
• Protein Sequence: MLKAVLKKSREGGKGSKKEAGGDFGSETPALSSSGDSPVNSLSTTEDTYRVSLAKGVSMSLPSSPLLPRQSLLTQSRSNKKSPGPVRKPKYVESPRVPGDPVMIPFGEGSKPSEPSATEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNEAMCTALSQGISPCSTLTSSTASPSTDSPCSTLNSCVSKTAASKSPCETISSPSSTLESKDSGIIATITSSSENDDRSGSSLEWNRDGSLRLGVQKGVLHDRRADNCSPVAEEETTGSAESVLPKAEPSAGDGPVPYPQSSGSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAPEVKARFAPYKPQEILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGSVGFGKTAIISKLVALSCHGSRMRQIASSSPSLSPKSSDPTQDLPGTPLLSPSSSTSALSVTRTPAGPGTADSQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTLSSFITKIIPKFPTWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDLHAYVQHRVHSSQDILSNISLNGKADAALISKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFDRALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQRMEALSCFLIKRRDKTRMFCHPSFREWLVWRADGESTAFLCEPRNGHALLAFMFSRQESKLNRQQTMELGHHILKAHIFKGLSKKTGVSSSHLQALWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAAASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREGLGEDMRPFNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEEECKQLQRNQQQKQQGPPPAPANDSDNEEDAPASSLKDHFPIEEAEEEDTSSQEESISPTPRSQPPPSVPSPYIRNLQEGLQSKGRSASPQSRAGISKSLRETVAQSGLVMQPTKQAQIVKTNQHLGSGQSSMRNSSTKIQVSSQNPPPSPMPGRVSAAPAVSRNQHLEGTGPFTAGTGCGHFGDRLGASQSLQLQRSESGTAYPLPSKVKAAERLLAHASVAVDMAPPNQGGPVSCSDVRHPASLSSSGSSGSPSSSIKMSSSTSSLTSSSSVSDGFKVQGPDSRIRDKGTTQVQGGTAEHRPRNTPFMGIMDKTARFQQQSNPPNRSWHCPVAEGLLTNTATAAGLQSNSEKPTLKPGGYCSQAKPCSVPPLSMGVHNGAQVKELEENKCQIPALCQDNRITKGVPHLYPEGVSKQPLHVSTEAHRSHLTSAKPKRSFIESNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLKAVLKK -------CHHHHHHH	38.98	-
9	Phosphorylation	LKAVLKKSREGGKGS HHHHHHHHCCCCCCC	33.70	22324799
58	Phosphorylation	VSLAKGVSMSLPSSP EEECCCCCCCCCCCC	16.01	25168779
60	Phosphorylation	LAKGVSMSLPSSPLL ECCCCCCCCCCCCCC	29.62	27087446
63	Phosphorylation	GVSMSLPSSPLLPRQ CCCCCCCCCCCCCHH	50.29	26824392
64	Phosphorylation	VSMSLPSSPLLPRQS CCCCCCCCCCCCHHH	20.02	27087446
76	Phosphorylation	RQSLLTQSRSNKKSP HHHHHHCCCCCCCCC	32.23	29514104
82	Phosphorylation	QSRSNKKSPGPVRKP CCCCCCCCCCCCCCC	36.38	26824392
91	Phosphorylation	GPVRKPKYVESPRVP CCCCCCCCCCCCCCC	20.27	-
127	Phosphorylation	AKADNEPSCSPAAQE CCCCCCCCCCHHHHH	22.50	28066266
129	Phosphorylation	ADNEPSCSPAAQELL CCCCCCCCHHHHHHH	23.16	26824392
199	Phosphorylation	LNSCVSKTAASKSPC HHHHHCCCCCCCCCC	21.68	25619855
202	Phosphorylation	CVSKTAASKSPCETI HHCCCCCCCCCCCCC	31.07	25619855
204	Phosphorylation	SKTAASKSPCETISS CCCCCCCCCCCCCCC	32.08	25619855
208	Phosphorylation	ASKSPCETISSPSST CCCCCCCCCCCCCHH	32.64	25619855
210	Phosphorylation	KSPCETISSPSSTLE CCCCCCCCCCCHHCC	43.55	25619855
211	Phosphorylation	SPCETISSPSSTLES CCCCCCCCCCHHCCC	25.58	25521595
213	Phosphorylation	CETISSPSSTLESKD CCCCCCCCHHCCCCC	37.59	24925903
214	Phosphorylation	ETISSPSSTLESKDS CCCCCCCHHCCCCCC	40.16	25619855
215	Phosphorylation	TISSPSSTLESKDSG CCCCCCHHCCCCCCC	38.59	24925903
218	Phosphorylation	SPSSTLESKDSGIIA CCCHHCCCCCCCEEE	44.89	25777480
221	Phosphorylation	STLESKDSGIIATIT HHCCCCCCCEEEEEE	35.31	22817900
240	Phosphorylation	NDDRSGSSLEWNRDG CCCCCCCCCEECCCC	33.56	28973931
248	Phosphorylation	LEWNRDGSLRLGVQK CEECCCCCEEEEEEC	18.01	27149854
267	Phosphorylation	DRRADNCSPVAEEET CCCCCCCCCCCCCCC	28.76	27087446
274	Phosphorylation	SPVAEEETTGSAESV CCCCCCCCCCCHHHH	39.47	25619855
275	Phosphorylation	PVAEEETTGSAESVL CCCCCCCCCCHHHHC	32.21	25619855
277	Phosphorylation	AEEETTGSAESVLPK CCCCCCCCHHHHCCC	27.11	25619855
288	Phosphorylation	VLPKAEPSAGDGPVP HCCCCCCCCCCCCCC	36.07	25619855
296	Phosphorylation	AGDGPVPYPQSSGSL CCCCCCCCCCCCCCE	17.71	25619855
299	Phosphorylation	GPVPYPQSSGSLIMP CCCCCCCCCCCEEEC	31.96	25619855
300	Phosphorylation	PVPYPQSSGSLIMPR CCCCCCCCCCEEECC	27.44	25619855
302	Phosphorylation	PYPQSSGSLIMPRPN CCCCCCCCEEECCCC	19.37	25619855
310	Phosphorylation	LIMPRPNSVAATSST EEECCCCCCCCCCCC	18.80	26824392
314	Phosphorylation	RPNSVAATSSTKLED CCCCCCCCCCCCHHH	17.30	25619855
315	Phosphorylation	PNSVAATSSTKLEDL CCCCCCCCCCCHHHH	31.14	25619855
316	Phosphorylation	NSVAATSSTKLEDLS CCCCCCCCCCHHHHH	25.80	25619855
317	Phosphorylation	SVAATSSTKLEDLSY CCCCCCCCCHHHHHH	39.14	25619855
335	Phosphorylation	QRNAPLRTSIRLPWH CCCCCCCEEEECCCC	35.87	23984901
336	Phosphorylation	RNAPLRTSIRLPWHN CCCCCCEEEECCCCC	10.16	21659605
418	Phosphorylation	GSVGFGKTAIISKLV CCCCCCHHHHHHHHH	24.38	28059163
428	Phosphorylation	ISKLVALSCHGSRMR HHHHHHHHCCHHHHH	8.37	28059163
439	Phosphorylation	SRMRQIASSSPSLSP HHHHHHHHCCCCCCC	32.74	25619855
440	Phosphorylation	RMRQIASSSPSLSPK HHHHHHHCCCCCCCC	36.93	25619855
441	Phosphorylation	MRQIASSSPSLSPKS HHHHHHCCCCCCCCC	18.93	25521595
443	Phosphorylation	QIASSSPSLSPKSSD HHHHCCCCCCCCCCC	43.35	21082442
445	Phosphorylation	ASSSPSLSPKSSDPT HHCCCCCCCCCCCCC	34.32	25521595
452	Phosphorylation	SPKSSDPTQDLPGTP CCCCCCCCCCCCCCC	39.44	-
458	Phosphorylation	PTQDLPGTPLLSPSS CCCCCCCCCCCCCCC	14.60	25619855
462	Phosphorylation	LPGTPLLSPSSSTSA CCCCCCCCCCCCCCC	30.34	22942356
464	Phosphorylation	GTPLLSPSSSTSALS CCCCCCCCCCCCCCE	33.28	25619855
465	Phosphorylation	TPLLSPSSSTSALSV CCCCCCCCCCCCCEE	40.81	25619855
466	Phosphorylation	PLLSPSSSTSALSVT CCCCCCCCCCCCEEE	30.62	25619855
467	Phosphorylation	LLSPSSSTSALSVTR CCCCCCCCCCCEEEE	21.70	28066266
468	Phosphorylation	LSPSSSTSALSVTRT CCCCCCCCCCEEEEC	29.21	28066266
471	Phosphorylation	SSSTSALSVTRTPAG CCCCCCCEEEECCCC	22.59	28066266
473	Phosphorylation	STSALSVTRTPAGPG CCCCCEEEECCCCCC	26.00	25619855
475	Phosphorylation	SALSVTRTPAGPGTA CCCEEEECCCCCCCC	14.23	28066266
703	Phosphorylation	RSLGSYLYLKLTLDL HHHHHHHHHHHHHHH	8.11	28576409
1334	Phosphorylation	PFNELRVSLYLNLSR CHHHHHHHHHHHHHH	12.59	24759943
1436	Phosphorylation	PPAPANDSDNEEDAP CCCCCCCCCCCCCCC	41.99	25521595
1445	Phosphorylation	NEEDAPASSLKDHFP CCCCCCHHHCCCCCC	34.83	28066266
1446	Phosphorylation	EEDAPASSLKDHFPI CCCCCHHHCCCCCCH	41.36	25619855
1461	Phosphorylation	EEAEEEDTSSQEESI HHHHCCCCCCCCCCC	33.29	25619855
1462	Phosphorylation	EAEEEDTSSQEESIS HHHCCCCCCCCCCCC	42.20	25521595
1463	Phosphorylation	AEEEDTSSQEESISP HHCCCCCCCCCCCCC	43.64	27087446
1467	Phosphorylation	DTSSQEESISPTPRS CCCCCCCCCCCCCCC	27.84	25619855
1469	Phosphorylation	SSQEESISPTPRSQP CCCCCCCCCCCCCCC	31.81	25619855
1471	Phosphorylation	QEESISPTPRSQPPP CCCCCCCCCCCCCCC	25.25	25619855
1484	Phosphorylation	PPSVPSPYIRNLQEG CCCCCCHHHHHHHHH	19.49	29514104
1494	Phosphorylation	NLQEGLQSKGRSASP HHHHHHHHCCCCCCH	41.96	26824392
1498	Phosphorylation	GLQSKGRSASPQSRA HHHHCCCCCCHHHHH	41.59	23375375
1510	Phosphorylation	SRAGISKSLRETVAQ HHHCCCHHHHHHHHH	26.35	23984901
1514	Phosphorylation	ISKSLRETVAQSGLV CCHHHHHHHHHCCCC	18.08	23984901
1554	Phosphorylation	SSTKIQVSSQNPPPS CCCCEEECCCCCCCC	15.16	25619855
1555	Phosphorylation	STKIQVSSQNPPPSP CCCEEECCCCCCCCC	34.81	25619855
1561	Phosphorylation	SSQNPPPSPMPGRVS CCCCCCCCCCCCCCC	39.34	25619855
1568	Phosphorylation	SPMPGRVSAAPAVSR CCCCCCCCCCCCCCC	19.83	23984901
1601	Phosphorylation	FGDRLGASQSLQLQR HHHCCCCCCCEEEEC	20.64	28066266
1603	Phosphorylation	DRLGASQSLQLQRSE HCCCCCCCEEEECCC	18.65	26824392
1609	Phosphorylation	QSLQLQRSESGTAYP CCEEEECCCCCCCCC	24.13	25619855
1611	Phosphorylation	LQLQRSESGTAYPLP EEEECCCCCCCCCCC	42.56	21082442
1613	Phosphorylation	LQRSESGTAYPLPSK EECCCCCCCCCCCHH	32.09	25619855
1615	Phosphorylation	RSESGTAYPLPSKVK CCCCCCCCCCCHHHH	12.73	25619855
1656	O-linked_Glycosylation	SDVRHPASLSSSGSS HHCCCCCCCCCCCCC	32.98	14209597
1656	Phosphorylation	SDVRHPASLSSSGSS HHCCCCCCCCCCCCC	32.98	25619855
1658	O-linked_Glycosylation	VRHPASLSSSGSSGS CCCCCCCCCCCCCCC	21.69	55414185
1658	Phosphorylation	VRHPASLSSSGSSGS CCCCCCCCCCCCCCC	21.69	25619855
1659	Phosphorylation	RHPASLSSSGSSGSP CCCCCCCCCCCCCCC	43.97	25619855
1660	Phosphorylation	HPASLSSSGSSGSPS CCCCCCCCCCCCCCC	39.04	25619855
1662	Phosphorylation	ASLSSSGSSGSPSSS CCCCCCCCCCCCCCC	33.21	25619855
1663	Phosphorylation	SLSSSGSSGSPSSSI CCCCCCCCCCCCCCC	46.98	25619855
1665	Phosphorylation	SSSGSSGSPSSSIKM CCCCCCCCCCCCCEE	24.45	26824392
1667	Phosphorylation	SGSSGSPSSSIKMSS CCCCCCCCCCCEECC	38.11	25619855
1668	Phosphorylation	GSSGSPSSSIKMSSS CCCCCCCCCCEECCC	39.19	25619855
1669	Phosphorylation	SSGSPSSSIKMSSST CCCCCCCCCEECCCC	30.48	25619855
1673	Phosphorylation	PSSSIKMSSSTSSLT CCCCCEECCCCCCCC	19.01	22817900
1674	Phosphorylation	SSSIKMSSSTSSLTS CCCCEECCCCCCCCC	33.85	26239621
1675	Phosphorylation	SSIKMSSSTSSLTSS CCCEECCCCCCCCCC	25.63	26239621
1676	Phosphorylation	SIKMSSSTSSLTSSS CCEECCCCCCCCCCC	25.04	26239621
1677	Phosphorylation	IKMSSSTSSLTSSSS CEECCCCCCCCCCCC	25.87	22817900
1678	Phosphorylation	KMSSSTSSLTSSSSV EECCCCCCCCCCCCC	35.44	22817900
1680	Phosphorylation	SSSTSSLTSSSSVSD CCCCCCCCCCCCCCC	28.63	21082442
1704	Phosphorylation	RIRDKGTTQVQGGTA CCCCCCCCEECCCCC	35.10	28066266
1710	Phosphorylation	TTQVQGGTAEHRPRN CCEECCCCCCCCCCC	35.38	28066266
1716	Methylation	GTAEHRPRNTPFMGI CCCCCCCCCCCCCCC	60.66	16289177

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1561	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TANC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TANC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TANC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1665, AND MASSSPECTROMETRY.
PubMed: 19367708