ES8L2_MOUSE - dbPTM
ES8L2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ES8L2_MOUSE
UniProt AC Q99K30
Protein Name Epidermal growth factor receptor kinase substrate 8-like protein 2
Gene Name Eps8l2
Organism Mus musculus (Mouse).
Sequence Length 729
Subcellular Localization Cytoplasm . Cell projection, stereocilium . Localizes at the tips of the stereocilia of the inner and outer hair cells.
Protein Description Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells. [PubMed: 23918390]
Protein Sequence MSQSASMSCCPGAANGSLGRSDGVPRMSAKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAIASVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLRLLDVESQEELENFPLPTVQHSQTVLNQLRYPSVLLLVCQDSDQNKPDIHFFHCDEVEAELVQEDIESALADYRLGKKMRPQTLKGHQEKIRQRQSILPPPQSPAPIPFQRQPGDSPQAKNRVGLPLPVPFSEPGYRRRESQDEEPRAVLAQRIEKETQILNCTLDDIEWFVARLQKAAEAFKQLNQRKKGKKKNKKGPAEGVLTLRARPPSEGEFVDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGSPDIARSVSSPLLSTDAVSFLRGHLVPKEMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEVEGLASVPSDQLTPKNRLSVRHSPKHSLSSESQAPEDIAPPGSSPHANRGYQPTPAMTKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRNRSGQAGYVPCNILAEARQEDVGAPLEQSGQKYWGPASPTHKLPPIFAGNKEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQPVHLPLTFESGPDEVRAWLEAKAFSARIVENLGILTGPQLFSLNKEELKKVCGEEGSRVYSQLTVQKAFLEKQQSGSELEKLMSKIRRAEDSYTSQHTSPESEGAPHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSQSASMSC
------CCCCCCCCC		32.6122324799
4Phosphorylation----MSQSASMSCCP
----CCCCCCCCCCC		18.2722324799
6Phosphorylation--MSQSASMSCCPGA
--CCCCCCCCCCCCC		19.2422324799
8PhosphorylationMSQSASMSCCPGAAN
CCCCCCCCCCCCCCC		15.2922324799
17PhosphorylationCPGAANGSLGRSDGV
CCCCCCCCCCCCCCC		27.7124723360
21PhosphorylationANGSLGRSDGVPRMS
CCCCCCCCCCCCCCC		36.6023984901
84MalonylationKLVQLSSKEKVWAQE
HHHHHCCCCCHHHHH		59.1726320211
184PhosphorylationGKKMRPQTLKGHQEK
CCCCCCHHHHHHHHH		32.8723140645
197PhosphorylationEKIRQRQSILPPPQS
HHHHHHHCCCCCCCC		28.4323984901
204PhosphorylationSILPPPQSPAPIPFQ
CCCCCCCCCCCCCCC		28.8926239621
217PhosphorylationFQRQPGDSPQAKNRV
CCCCCCCCCCCCCCC		25.4826239621
242PhosphorylationPGYRRRESQDEEPRA
CCCCCCCCCCCCHHH		40.9122324799
284MalonylationQKAAEAFKQLNQRKK
HHHHHHHHHHHHHHC		62.0126320211
306PhosphorylationGPAEGVLTLRARPPS
CCCCCEEEEEECCCC		16.2821082442
313PhosphorylationTLRARPPSEGEFVDC
EEEECCCCCCCCCHH		62.0029899451
320S-palmitoylationSEGEFVDCFQKTKLA
CCCCCCHHHHHHHHH		3.0626165157
445PhosphorylationWEVEGLASVPSDQLT
CEEECEECCCHHHCC		39.3323984901
448PhosphorylationEGLASVPSDQLTPKN
ECEECCCHHHCCCCC		35.5123984901
452PhosphorylationSVPSDQLTPKNRLSV
CCCHHHCCCCCCCCC		26.9523984901
458PhosphorylationLTPKNRLSVRHSPKH
CCCCCCCCCCCCCCC		17.5430352176
462PhosphorylationNRLSVRHSPKHSLSS
CCCCCCCCCCCCCCC		25.6926824392
466PhosphorylationVRHSPKHSLSSESQA
CCCCCCCCCCCCCCC		35.7528973931
468PhosphorylationHSPKHSLSSESQAPE
CCCCCCCCCCCCCCC		34.7727818261
469PhosphorylationSPKHSLSSESQAPED
CCCCCCCCCCCCCCC		46.7025619855
471PhosphorylationKHSLSSESQAPEDIA
CCCCCCCCCCCCCCC		33.3225619855
482PhosphorylationEDIAPPGSSPHANRG
CCCCCCCCCCCCCCC		46.6127818261
483PhosphorylationDIAPPGSSPHANRGY
CCCCCCCCCCCCCCC		26.9827087446
568PhosphorylationLEQSGQKYWGPASPT
HHHHCCCCCCCCCCC		14.0123984901
573PhosphorylationQKYWGPASPTHKLPP
CCCCCCCCCCCCCCC		33.2025521595
575PhosphorylationYWGPASPTHKLPPIF
CCCCCCCCCCCCCCC		29.1924925903
681PhosphorylationGEEGSRVYSQLTVQK
CCCCCHHHHHHHHHH		6.9217242355
682PhosphorylationEEGSRVYSQLTVQKA
CCCCHHHHHHHHHHH		18.8229472430
685PhosphorylationSRVYSQLTVQKAFLE
CHHHHHHHHHHHHHH		17.1629472430
696PhosphorylationAFLEKQQSGSELEKL
HHHHHHCCHHHHHHH		41.6227818261
698PhosphorylationLEKQQSGSELEKLMS
HHHHCCHHHHHHHHH		44.2322324799
713PhosphorylationKIRRAEDSYTSQHTS
HHHHHHHCCCCCCCC		23.0929899451
714PhosphorylationIRRAEDSYTSQHTSP
HHHHHHCCCCCCCCC		23.8024925903
715PhosphorylationRRAEDSYTSQHTSPE
HHHHHCCCCCCCCCC		26.3426239621
716PhosphorylationRAEDSYTSQHTSPES
HHHHCCCCCCCCCCC		16.2529899451
719PhosphorylationDSYTSQHTSPESEGA
HCCCCCCCCCCCCCC		38.0424925903
720PhosphorylationSYTSQHTSPESEGAP
CCCCCCCCCCCCCCC		25.2524925903
723PhosphorylationSQHTSPESEGAPHL-
CCCCCCCCCCCCCC-		44.7224925903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ES8L2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ES8L2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ES8L2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ES8L2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ES8L2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242 AND SER-483, ANDMASS SPECTROMETRY.

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