KIF4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF4_MOUSE
• UniProt AC: P33174
• Protein Name: Chromosome-associated kinesin KIF4
• Gene Name: Kif4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1231
• Subcellular Localization: Nucleus . Chromosome . Cytoplasm, cytoskeleton . Associated with mitotic chromosomes.
• Protein Description: Required for mitotic chromosomal positioning and bipolar spindle stabilization..
• Protein Sequence: MKEEVKGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKVDLQKLVETLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELELRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHFAKIETELKEELVKVEQQHQEKVLYLLSQLQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQQLLQENSAIKQKLTLLQVASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQSFAVEGLQYYSEPSVAEQDNEDSDDHADEEWIPTKLVKVSKKSIQGCSCKGWCGNKQCGCRKQKSDCNVSCSCDPTKCRNRHQNQDNSDAIELNQDSENSFKLEDPTEVTSGLSFFHPICATPSSKILKEMCDADQVQLKQPVFVSSSDHPELKSIASESQENKAIGKKKKRALASNTSFFSGCSPIQEESH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	IKGVFKGYNATVLAY HHHHHCCCCEEEEEE	11.38	25293948
83	Phosphorylation	VFKGYNATVLAYGQT HHCCCCEEEEEECCC	16.65	25293948
87	Phosphorylation	YNATVLAYGQTGSGK CCEEEEEECCCCCCC	12.95	25293948
90	Phosphorylation	TVLAYGQTGSGKTYS EEEEECCCCCCCEEE	29.02	25293948
92	Phosphorylation	LAYGQTGSGKTYSMG EEECCCCCCCEEECC	40.27	25293948
226	Acetylation	ISIEQRKKNDKNSSF EEHHHHHHCCCCCCH	72.99	15607457
235	Phosphorylation	DKNSSFRSKLHLVDL CCCCCHHHHHHHHHH	37.24	-
289	Phosphorylation	KKGNFVPYRDSKLTR CCCCCCCCCCHHHHH	23.04	27149854
292	Phosphorylation	NFVPYRDSKLTRLLQ CCCCCCCHHHHHHHH	22.14	27149854
395	Phosphorylation	SLMEKNQSLVEENEK HHHHHCHHHHHHHHH	43.72	26824392
404	Phosphorylation	VEENEKLSRGLSEAA HHHHHHHHHHHHHHH	35.06	-
434	Acetylation	ANEKMNAKLEELRRH HHHHHHHHHHHHHHH	51.97	6567267
571	Phosphorylation	NLESEVLSLQREKEE HHHHHHHHHHHHHHH	27.86	29514104
622	Acetylation	KKLQEQSKLLKLKES HHHHHHHHHHHHHHH	58.49	2389689
625	Acetylation	QEQSKLLKLKESTEH HHHHHHHHHHHHHHH	68.87	2389697
705	Phosphorylation	SNVLRRKTEEAAAAN HHHHHHHHHHHHHHH	36.93	-
788	Phosphorylation	QLKEKRESGENPPLK HHHHHHHCCCCCCCH	56.28	26824392
800	Phosphorylation	PLKLRRRTFSYDEIH CCHHHEEEEEHHHCC	18.34	21082442
802	Phosphorylation	KLRRRTFSYDEIHGQ HHHEEEEEHHHCCCC	30.94	26824392
803	Phosphorylation	LRRRTFSYDEIHGQD HHEEEEEHHHCCCCC	17.26	21082442
811	Phosphorylation	DEIHGQDSGAEDSIA HHCCCCCCCCHHHHH	31.83	22802335
816	Phosphorylation	QDSGAEDSIAKQIES CCCCCHHHHHHHHHH	18.89	25619855
888	Phosphorylation	LVSKLESSLNQSKAS HHHHHHHHCCHHHHH	23.20	26824392
942	Phosphorylation	LLSQLQQSQMTEKQL HHHHHHHHHCCHHHH	14.68	27841257
945	Phosphorylation	QLQQSQMTEKQLEES HHHHHHCCHHHHHHH	32.18	29514104
952	Phosphorylation	TEKQLEESVSEKEQQ CHHHHHHHHHHHHHH	22.90	24453211
954	Phosphorylation	KQLEESVSEKEQQLL HHHHHHHHHHHHHHH	52.83	28066266
962	Phosphorylation	EKEQQLLSTLKCQEE HHHHHHHHHHHHHHH	40.04	28066266
963	Phosphorylation	KEQQLLSTLKCQEEE HHHHHHHHHHHHHHH	30.15	28066266
989	Phosphorylation	QQLLQENSAIKQKLT HHHHHHCHHHHHHHH	30.53	25266776
1002	Phosphorylation	LTLLQVASKQKPHLT HHHHHHHHCCCCCCC	36.44	26824392
1015	Phosphorylation	LTRNIFQSPDSSFEY CCCCCCCCCCCCCCC	21.67	26370283
1018	Phosphorylation	NIFQSPDSSFEYIPP CCCCCCCCCCCCCCC	40.07	26370283
1053	Phosphorylation	LQYYSEPSVAEQDNE CCEECCCCCCCCCCC	29.88	21659604
1062	Phosphorylation	AEQDNEDSDDHADEE CCCCCCCCCCCCCCC	38.47	24224561
1136	Phosphorylation	AIELNQDSENSFKLE CCCCCCCCCCCCCCC	28.99	21149613
1139	Phosphorylation	LNQDSENSFKLEDPT CCCCCCCCCCCCCCC	21.51	21149613
1215	Phosphorylation	KKKRALASNTSFFSG HHHHHHHCCCCCCCC	41.30	25619855
1217	Phosphorylation	KRALASNTSFFSGCS HHHHHCCCCCCCCCC	25.15	25619855
1218	Phosphorylation	RALASNTSFFSGCSP HHHHCCCCCCCCCCC	28.66	21082442
1221	Phosphorylation	ASNTSFFSGCSPIQE HCCCCCCCCCCCCCC	36.56	25619855
1224	Phosphorylation	TSFFSGCSPIQEESH CCCCCCCCCCCCCCC	28.67	27087446
1230	Phosphorylation	CSPIQEESH------ CCCCCCCCC------	33.47	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF4A_HUMAN	KIF4A	physical	20360068
CE170_HUMAN	CEP170	physical	20360068
GCP2_HUMAN	TUBGCP2	physical	20360068
PRC1_HUMAN	PRC1	physical	20360068
CALD1_HUMAN	CALD1	physical	26496610
AP3S1_HUMAN	AP3S1	physical	26496610
TAF2_HUMAN	TAF2	physical	26496610
UMPS_HUMAN	UMPS	physical	26496610
LIPA1_HUMAN	PPFIA1	physical	26496610
S23IP_HUMAN	SEC23IP	physical	26496610
RB6I2_HUMAN	ERC1	physical	26496610
GRAM4_HUMAN	GRAMD4	physical	26496610
PANX1_HUMAN	PANX1	physical	26496610
INT6_HUMAN	INTS6	physical	26496610
RM35_HUMAN	MRPL35	physical	26496610
FBP1L_HUMAN	FNBP1L	physical	26496610
PLXA3_HUMAN	PLXNA3	physical	26496610
CENPJ_HUMAN	CENPJ	physical	26496610
RN213_HUMAN	RNF213	physical	26496610
GPBP1_HUMAN	GPBP1	physical	26496610
STN1_HUMAN	OBFC1	physical	26496610
CHD9_HUMAN	CHD9	physical	26496610
RIOK1_HUMAN	RIOK1	physical	26496610
USMG5_HUMAN	USMG5	physical	26496610
MCU_HUMAN	MCU	physical	26496610
PR14L_HUMAN	PRR14L	physical	26496610
KIF4B_HUMAN	KIF4B	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.