GPBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPBP1_HUMAN
• UniProt AC: Q86WP2
• Protein Name: Vasculin
• Gene Name: GPBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 473
• Subcellular Localization: Nucleus . Cytoplasm . According to PubMed:12842993, it localizes to the cytoplasm.
• Protein Description: Functions as a GC-rich promoter-specific transactivating transcription factor..
• Protein Sequence: MAQHDFAPAWLNFPTPPSSTKSSLNFEKHSENFAWTENRYDVNRRRHNSSDGFDSAIGRPNGGNFGRKEKNGWRTHGRNGTENINHRGGYHGGSSRSRSSIFHAGKSQGLHENNIPDNETGRKEDKRERKQFEAEDFPSLNPEYEREPNHNKSLAAGVWEYPPNPKSRAPRMLVIKKGNTKDLQLSGFPVVGNLPSQPVKNGTGPSVYKGLVPKPAAPPTKPTQWKSQTKENKVGTSFPHESTFGVGNFNAFKSTAKNFSPSTNSVKECNRSNSSSPVDKLNQQPRLTKLTRMRTDKKSEFLKALKRDRVEEEHEDESRAGSEKDDDSFNLHNSNSTHQERDINRNFDENEIPQENGNASVISQQIIRSSTFPQTDVLSSSLEAEHRLLKEMGWQEDSENDETCAPLTEDEMREFQVISEQLQKNGLRKNGILKNGLICDFKFGPWKNSTFKPTTENDDTETSSSDTSDDDDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PAWLNFPTPPSSTKS CCHHCCCCCCCCCCC	43.63	22199227
18	Phosphorylation	LNFPTPPSSTKSSLN HCCCCCCCCCCCCCC	52.41	22199227
19	Phosphorylation	NFPTPPSSTKSSLNF CCCCCCCCCCCCCCC	45.70	22199227
20	Phosphorylation	FPTPPSSTKSSLNFE CCCCCCCCCCCCCCC	39.00	22199227
30 (in isoform 3)	Phosphorylation	-	45.35	-
30 (in isoform 2)	Phosphorylation	-	45.35	-
40	Phosphorylation	FAWTENRYDVNRRRH CCCCCCCCCCCHHCC	35.51	-
49	Phosphorylation	VNRRRHNSSDGFDSA CCHHCCCCCCCHHHC	24.55	23401153
50	Phosphorylation	NRRRHNSSDGFDSAI CHHCCCCCCCHHHCC	47.25	27273156
55	Phosphorylation	NSSDGFDSAIGRPNG CCCCCHHHCCCCCCC	21.37	23927012
87	Methylation	GTENINHRGGYHGGS CCCCCCCCCCCCCCC	35.43	24129315
90	Phosphorylation	NINHRGGYHGGSSRS CCCCCCCCCCCCCCC	10.50	23403867
94	Phosphorylation	RGGYHGGSSRSRSSI CCCCCCCCCCCHHHC	27.46	23403867
95	Phosphorylation	GGYHGGSSRSRSSIF CCCCCCCCCCHHHCC	37.23	23403867
97	Phosphorylation	YHGGSSRSRSSIFHA CCCCCCCCHHHCCCC	38.16	27251275
99	Phosphorylation	GGSSRSRSSIFHAGK CCCCCCHHHCCCCCC	29.09	27251275
100	Phosphorylation	GSSRSRSSIFHAGKS CCCCCHHHCCCCCCC	28.32	27251275
139	Phosphorylation	FEAEDFPSLNPEYER HHHHCCCCCCHHHCC	40.55	28555341
144	Phosphorylation	FPSLNPEYEREPNHN CCCCCHHHCCCCCCC	22.88	-
196	Phosphorylation	PVVGNLPSQPVKNGT CEECCCCCCCCCCCC	50.73	-
260	Phosphorylation	KSTAKNFSPSTNSVK HHHCCCCCCCCCCHH	27.60	29496963
262	Phosphorylation	TAKNFSPSTNSVKEC HCCCCCCCCCCHHHH	38.74	28985074
263	Phosphorylation	AKNFSPSTNSVKECN CCCCCCCCCCHHHHC	34.59	29396449
265	Phosphorylation	NFSPSTNSVKECNRS CCCCCCCCHHHHCCC	34.35	27251275
272	Phosphorylation	SVKECNRSNSSSPVD CHHHHCCCCCCCHHH	27.37	23312004
274	Phosphorylation	KECNRSNSSSPVDKL HHHCCCCCCCHHHHH	33.18	23312004
275	Phosphorylation	ECNRSNSSSPVDKLN HHCCCCCCCHHHHHH	42.80	24719451
276	Phosphorylation	CNRSNSSSPVDKLNQ HCCCCCCCHHHHHHC	28.85	25849741
288	Phosphorylation	LNQQPRLTKLTRMRT HHCCCCHHHHHHHCC	25.86	-
291	Phosphorylation	QPRLTKLTRMRTDKK CCCHHHHHHHCCCCH	24.79	-
295	Phosphorylation	TKLTRMRTDKKSEFL HHHHHHCCCCHHHHH	42.71	-
318	Phosphorylation	EEEHEDESRAGSEKD HHHCCCCCCCCCCCC	39.49	29255136
322	Phosphorylation	EDESRAGSEKDDDSF CCCCCCCCCCCCCCC	40.25	30266825
328	Phosphorylation	GSEKDDDSFNLHNSN CCCCCCCCCCCCCCC	24.03	30266825
334	Phosphorylation	DSFNLHNSNSTHQER CCCCCCCCCCHHHHH	22.78	23927012
336	Phosphorylation	FNLHNSNSTHQERDI CCCCCCCCHHHHHHC	27.38	23927012
337	Phosphorylation	NLHNSNSTHQERDIN CCCCCCCHHHHHHCC	31.65	23927012
360	Phosphorylation	PQENGNASVISQQII CCCCCCCCHHCHHHH	24.80	28555341
369	Phosphorylation	ISQQIIRSSTFPQTD HCHHHHHCCCCCCHH	24.26	23403867
370	Phosphorylation	SQQIIRSSTFPQTDV CHHHHHCCCCCCHHH	24.99	23403867
371	Phosphorylation	QQIIRSSTFPQTDVL HHHHHCCCCCCHHHH	40.35	23403867
375	Phosphorylation	RSSTFPQTDVLSSSL HCCCCCCHHHHCHHH	28.45	28102081
379	Phosphorylation	FPQTDVLSSSLEAEH CCCHHHHCHHHHHHH	20.10	30266825
380	Phosphorylation	PQTDVLSSSLEAEHR CCHHHHCHHHHHHHH	34.48	23401153
381	Phosphorylation	QTDVLSSSLEAEHRL CHHHHCHHHHHHHHH	27.18	30266825
398	Phosphorylation	EMGWQEDSENDETCA HHCCCCCCCCCCCCC	37.23	23927012
403	Phosphorylation	EDSENDETCAPLTED CCCCCCCCCCCCCHH	19.48	23927012
408	Phosphorylation	DETCAPLTEDEMREF CCCCCCCCHHHHHHH	40.09	26074081
424	Ubiquitination	VISEQLQKNGLRKNG HHHHHHHHCCCCCCC	62.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPBP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FND11_HUMAN	C20orf195	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	25416956
PKP3_HUMAN	PKP3	physical	28514442
PLCD1_HUMAN	PLCD1	physical	28514442
OTUB2_HUMAN	OTUB2	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
E41L5_HUMAN	EPB41L5	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
H15_HUMAN	HIST1H1B	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
EIF3A_HUMAN	EIF3A	physical	28514442
EIF3C_HUMAN	EIF3C	physical	28514442
CRYAB_HUMAN	CRYAB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.