KIF4B_HUMAN - dbPTM
KIF4B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIF4B_HUMAN
UniProt AC Q2VIQ3
Protein Name Chromosome-associated kinesin KIF4B
Gene Name KIF4B
Organism Homo sapiens (Human).
Sequence Length 1234
Subcellular Localization Nucleus matrix. Cytoplasm, cytoskeleton .
Protein Description Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity)..
Protein Sequence MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVGTDKSFTYDFVFDPCTEQEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETSPETSRSSDAFTTQHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTFSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQKLLDAESEDRPKQCWENIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQKMLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQKLILLQVASRQKHLPNDTLLSPDSSFEYIPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDGDSDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCSCDPTKCRNRQQGKDSLGTVEQTQDSEGSFKLEDPTEVTPGLSFFNPVCATPNSKILKEMCDMEQVLSKKTAPAPSPFDLPESKHGATEYQQNKPPGKKKKRALASNTSFFSGCSPIEEEAH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
129UbiquitinationLFKEIDKKSDFEFTL
HHHHHCCCCCCEEEE		52.05-
158UbiquitinationLLCPSREKAQINIRE
HHCCCHHHHCCCCCC		44.47-
172UbiquitinationEDPKEGIKIVGLTEK
CCCCCCEEEEECCCC		42.04-
180PhosphorylationIVGLTEKTVLVALDT
EEECCCCEEEEEEEH		16.9130377224
187PhosphorylationTVLVALDTVSCLEQG
EEEEEEEHHHHHHCC		18.3730377224
189PhosphorylationLVALDTVSCLEQGNN
EEEEEHHHHHHCCCC		18.3130377224
197PhosphorylationCLEQGNNSRTVASTA
HHHCCCCCHHHHHHH		33.0730377224
199PhosphorylationEQGNNSRTVASTAMN
HCCCCCHHHHHHHCC		21.9030377224
203PhosphorylationNSRTVASTAMNSQSS
CCHHHHHHHCCCCCC		21.86-
207PhosphorylationVASTAMNSQSSRSHA
HHHHHCCCCCCCCCE		20.5327732954
209PhosphorylationSTAMNSQSSRSHAIF
HHHCCCCCCCCCEEE		27.7827732954
210PhosphorylationTAMNSQSSRSHAIFT
HHCCCCCCCCCEEEE		30.1127732954
234PhosphorylationDKNCSFRSKLHLVDL
CCCCCHHHHHHHHHH		37.2424719451
235UbiquitinationKNCSFRSKLHLVDLA
CCCCHHHHHHHHHHC		35.35-
244PhosphorylationHLVDLAGSERQKKTK
HHHHHCCCHHHHCHH		24.81-
250PhosphorylationGSERQKKTKAEGDRL
CCHHHHCHHCCCCHH		42.3923403867
251UbiquitinationSERQKKTKAEGDRLK
CHHHHCHHCCCCHHH		54.01-
258UbiquitinationKAEGDRLKEGININR
HCCCCHHHHCCCCCC		55.58-
269GlutathionylationNINRGLLCLGNVISA
CCCCHHHHHHHHHHH		5.7122555962
292UbiquitinationFVPYRDSKLTRLLQD
CCCCCCCHHHHHHHH		59.16-
294PhosphorylationPYRDSKLTRLLQDSL
CCCCCHHHHHHHHHC		24.0220068231
300PhosphorylationLTRLLQDSLGGNSHT
HHHHHHHHCCCCCEE		18.8924043423
305PhosphorylationQDSLGGNSHTLMIAC
HHHCCCCCEEEEEEE		22.5624043423
307PhosphorylationSLGGNSHTLMIACVS
HCCCCCEEEEEEEEC		20.1724043423
314PhosphorylationTLMIACVSPADSNLE
EEEEEEECCCCCCHH		17.7924043423
318PhosphorylationACVSPADSNLEETLS
EEECCCCCCHHHHHH		45.4824043423
323PhosphorylationADSNLEETLSTLRYA
CCCCHHHHHHHHHHH		19.3424043423
325PhosphorylationSNLEETLSTLRYADR
CCHHHHHHHHHHHHH		32.5824043423
326PhosphorylationNLEETLSTLRYADRA
CHHHHHHHHHHHHHH		20.5424043423
394PhosphorylationSLMEKNQSLVEENEK
HHHHHCHHHHHHHHH		43.7229255136
401UbiquitinationSLVEENEKLSRCLSK
HHHHHHHHHHHHHHH		64.44-
401SumoylationSLVEENEKLSRCLSK
HHHHHHHHHHHHHHH		64.44-
401SumoylationSLVEENEKLSRCLSK
HHHHHHHHHHHHHHH		64.44-
407PhosphorylationEKLSRCLSKAAGQTA
HHHHHHHHHHCHHHH		24.71-
449UbiquitinationACKLDLQKLVETLED
HHHHHHHHHHHHHCH		62.89-
460SumoylationTLEDQELKENVEIIC
HHCHHHHHHHHHHHH		46.63-
474PhosphorylationCNLQQLITQLSDETV
HHHHHHHHHCCCCHH		31.8617081983
507PhosphorylationTSPETSRSSDAFTTQ
CCCCCCCCCCCHHHH		32.1319691289
508PhosphorylationSPETSRSSDAFTTQH
CCCCCCCCCCHHHHH		31.6719691289
557PhosphorylationLQPIQFQYQDNIKNL
CCCCEEECHHHHCCC		21.08-
584PhosphorylationELVRELQTAKKNVNQ
HHHHHHHHHHHHHHH		53.7428258704
624AcetylationNEQSKLLKLKESTER
HHHHHHHHHHHHHHH		68.877266935
670UbiquitinationQWKQKKDKEVIQLKE
HHHHHCCHHHHHHHH		63.86-
676UbiquitinationDKEVIQLKERDRKRQ
CHHHHHHHHHHHHHH		34.04-
684PhosphorylationERDRKRQYELLKLER
HHHHHHHHHHHHHHH		16.7528152594
688UbiquitinationKRQYELLKLERNFQK
HHHHHHHHHHHHHHH		62.01-
715UbiquitinationAAANKRLKDALQKQR
HHHHHHHHHHHHHHH		45.01-
799PhosphorylationPPKLRKCTFSLSEVH
CCCHHHCEEEHHHHH		21.21-
801PhosphorylationKLRKCTFSLSEVHGQ
CHHHCEEEHHHHHCH		16.91-
840UbiquitinationQIADLQQKLLDAESE
HHHHHHHHHHHCCCC		37.7521890473
868AcetylationLEAKCALKYLIGELV
HHHHHHHHHHHHHHH		21.34-
869PhosphorylationEAKCALKYLIGELVS
HHHHHHHHHHHHHHH		12.3820068231
876PhosphorylationYLIGELVSSKIHVTK
HHHHHHHHCCCCHHH		38.2420068231
877PhosphorylationLIGELVSSKIHVTKL
HHHHHHHCCCCHHHH		28.3120068231
933PhosphorylationQHQEKVLYLVSQLQE
HHHHHHHHHHHHHHH		14.1929978859
936PhosphorylationEKVLYLVSQLQESQM
HHHHHHHHHHHHHHH		23.6829978859
941PhosphorylationLVSQLQESQMAEKQL
HHHHHHHHHHHHHHH		16.5829978859
951PhosphorylationAEKQLEKSASEKEQQ
HHHHHHHCHHHHHHH		27.87-
961PhosphorylationEKEQQLVSTLQCQDE
HHHHHHHHHHHCCHH		31.8024275569
1001PhosphorylationLILLQVASRQKHLPN
HHHHHHHHCCCCCCC		36.07-
1013PhosphorylationLPNDTLLSPDSSFEY
CCCCCCCCCCCCCCC		29.76-
1017PhosphorylationTLLSPDSSFEYIPPK
CCCCCCCCCCCCCCC		29.49-
1028PhosphorylationIPPKPKPSRVKEKFL
CCCCCCCCHHHHHHH		56.69-
1038PhosphorylationKEKFLEQSMDIEDLK
HHHHHHHCCCHHHHH		14.7329255136
1046PhosphorylationMDIEDLKYCSEHSVN
CCHHHHHHHHHCCCC		14.4317081983
1048PhosphorylationIEDLKYCSEHSVNEH
HHHHHHHHHCCCCCC		34.9428985074
1051PhosphorylationLKYCSEHSVNEHEDG
HHHHHHCCCCCCCCC		23.6828985074
1097UbiquitinationCKGWCGNKQCGCRKQ
CCCCCCCCCCCCCCC		32.05-
1106PhosphorylationCGCRKQKSDCGVDCS
CCCCCCCCCCCCCCC		35.32-
1113PhosphorylationSDCGVDCSCDPTKCR
CCCCCCCCCCCHHCC		19.66-
1117PhosphorylationVDCSCDPTKCRNRQQ
CCCCCCCHHCCCCCC		29.53-
1128PhosphorylationNRQQGKDSLGTVEQT
CCCCCCCCCCCCEEC		31.98-
1135PhosphorylationSLGTVEQTQDSEGSF
CCCCCEECCCCCCCE		22.3423663014
1138PhosphorylationTVEQTQDSEGSFKLE
CCEECCCCCCCEECC		33.7623663014
1141PhosphorylationQTQDSEGSFKLEDPT
ECCCCCCCEECCCCC		18.3723663014
1148PhosphorylationSFKLEDPTEVTPGLS
CEECCCCCCCCCCCC		56.2423663014
1151PhosphorylationLEDPTEVTPGLSFFN
CCCCCCCCCCCCCCC		12.8523663014
1155PhosphorylationTEVTPGLSFFNPVCA
CCCCCCCCCCCCCCC		33.4429255136
1163PhosphorylationFFNPVCATPNSKILK
CCCCCCCCCCHHHHH		20.2029255136
1166PhosphorylationPVCATPNSKILKEMC
CCCCCCCHHHHHHHC		23.4429255136
1183PhosphorylationEQVLSKKTAPAPSPF
HHHHCCCCCCCCCCC		41.4322461510
1188PhosphorylationKKTAPAPSPFDLPES
CCCCCCCCCCCCCCC		40.06-
1200PhosphorylationPESKHGATEYQQNKP
CCCCCCCCHHHCCCC		39.5622461510
1202PhosphorylationSKHGATEYQQNKPPG
CCCCCCHHHCCCCCC		15.8522461510
1218PhosphorylationKKKRALASNTSFFSG
HHHHHHHCCCCCCCC		41.3022167270
1220PhosphorylationKRALASNTSFFSGCS
HHHHHCCCCCCCCCC		25.1522167270
1221PhosphorylationRALASNTSFFSGCSP
HHHHCCCCCCCCCCC		28.6622167270
1224PhosphorylationASNTSFFSGCSPIEE
HCCCCCCCCCCCCCC		36.5622167270
1227PhosphorylationTSFFSGCSPIEEEAH
CCCCCCCCCCCCCCC		32.2222167270
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIF4B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIF4B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIF4B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KIF4B_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIF4B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1038, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1038 AND SER-1227, ANDMASS SPECTROMETRY.

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