UBA6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBA6_MOUSE
• UniProt AC: Q8C7R4
• Protein Name: Ubiquitin-like modifier-activating enzyme 6
• Gene Name: Uba6
• Organism: Mus musculus (Mouse).
• Sequence Length: 1053
• Protein Description: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34 (By similarity). Essential for embryonic development. Required for UBD/FAT10 conjugation..
• Protein Sequence: MERSEPLAVLSCEEASCSSWGACGASKNLPTMTTESLEIDDGLYSRQRYVLGDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQAWDLGTNFFLCEDDVVNERNRAEAVLHRIAELNPYVQVSSSSAPLDETTDLSFLEKYQCVVLTEIKLTLQKKINNFCHSHCPPIKFISADVHGIWSRLFCDFGDEFEVSDTTGEEPKEIFISNITQANPGIVTCLESHPHKLETGQFLTFREIHGMTGLNGSVQQITVISPFSFSIGDTTKLDPYLHGGIAVQVKTPKTFCFEPLESQIKHPRCLIADFSKPEAPLEIHLAMLALDQFQENYNRKPNIRCQQDSDELLKLTVSINETLEEKPEVNADIVHWLSWTAQGFLPPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADTVESLGNPGHEEFLPRGDRYDAIRACIGNTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTGREKGMVTVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAAEATLKINPQLKIDAHLNKVCPATESIYSDEFYTKQDIIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEIIVPQLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQAYPSAEDVLQKIQNGQSLEGCFQVIKLLSRRPRIWSQCVELARLKFEKYFNHKALQLLHCFPLETRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQSAAKLYATVYCIPFSEKDLSVNSLMDILSEVKIEEFKPSNKVVQTDETARKPDHVPVSSEDERNAVFQLEEALSSNKATKSDLQMTVLSFEKDDDRNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATSTAAVSGLVALEMIKVAGGYPFDAYKNCFLNLAIPIIVFTETSEVRKTEIRNGISFTIWDRWTVHGKEDFTLSDFINAVKENYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPSTEKKYVDLTVSFAPDADGDEDLPGPPVRYYFSHDTNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MERSEPLA -------CCCCCCEE	42.26	-
36	Phosphorylation	LPTMTTESLEIDDGL CCCCCCCCEEECCCH	29.25	25293948
44	Phosphorylation	LEIDDGLYSRQRYVL EEECCCHHHCCHHHH	13.82	25293948
54	Phosphorylation	QRYVLGDTAMQKMAK CHHHHCHHHHHHHHH	23.41	-
136	Phosphorylation	LNPYVQVSSSSAPLD HCCCEEEECCCCCCC	13.86	-
241	Phosphorylation	SHPHKLETGQFLTFR CCCCCCCCCCEEEEH	46.87	28066266
246	Phosphorylation	LETGQFLTFREIHGM CCCCCEEEEHHHHCC	23.18	28066266
298	Glutathionylation	VKTPKTFCFEPLESQ EECCCCCCCCCCHHH	4.58	24333276
503	Ubiquitination	TDPDLIEKSNLNRQF CCHHHHHHCCCCCCC	37.34	22790023
544	Acetylation	KIDAHLNKVCPATES CCCEECCCCCCCCCH	52.12	23236377
544	Ubiquitination	KIDAHLNKVCPATES CCCEECCCCCCCCCH	52.12	22790023
652	Ubiquitination	FESSFSHKPSLFNKF HHHHHCCCHHHHHHH	34.79	22790023
726	Phosphorylation	LHCFPLETRLKDGSL HHCEECCEECCCCCC	49.32	24719451
729	Ubiquitination	FPLETRLKDGSLFWQ EECCEECCCCCCCCC	57.67	27667366
729	Acetylation	FPLETRLKDGSLFWQ EECCEECCCCCCCCC	57.67	23806337
737	Phosphorylation	DGSLFWQSPKRPPSP CCCCCCCCCCCCCCC	24.00	28066266
739	Ubiquitination	SLFWQSPKRPPSPIK CCCCCCCCCCCCCCC	80.79	22790023
743	Phosphorylation	QSPKRPPSPIKFDLN CCCCCCCCCCCCCCC	41.77	26824392
779	Phosphorylation	PFSEKDLSVNSLMDI ECCHHCCCHHHHHHH	29.41	22817900
782	Phosphorylation	EKDLSVNSLMDILSE HHCCCHHHHHHHHHH	23.94	29899451
817	Phosphorylation	KPDHVPVSSEDERNA CCCCCCCCCHHHHHH	23.18	29233185
818	Phosphorylation	PDHVPVSSEDERNAV CCCCCCCCHHHHHHH	49.67	29233185
836	Ubiquitination	EEALSSNKATKSDLQ HHHHHCCCCCHHHHE	60.42	22790023
838	Phosphorylation	ALSSNKATKSDLQMT HHHCCCCCHHHHEEE	32.46	26239621
839	Ubiquitination	LSSNKATKSDLQMTV HHCCCCCHHHHEEEE	47.00	22790023
840	Phosphorylation	SSNKATKSDLQMTVL HCCCCCHHHHEEEEE	38.92	26239621
845	Phosphorylation	TKSDLQMTVLSFEKD CHHHHEEEEEEEECC	12.82	26239621
848	Phosphorylation	DLQMTVLSFEKDDDR HHEEEEEEEECCCCC	27.33	26239621
882	Ubiquitination	IEPADRFKTKRIAGK CCCHHHHCCHHHCCC	54.77	22790023
889	Ubiquitination	KTKRIAGKIIPAIAT CCHHHCCCHHHHHHH	28.57	-
951	Phosphorylation	TEIRNGISFTIWDRW CCCCCCCEEEEEECE	20.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBA6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBA6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBA6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBA6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.