K1C19_MOUSE - dbPTM
K1C19_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K1C19_MOUSE
UniProt AC P19001
Protein Name Keratin, type I cytoskeletal 19
Gene Name Krt19
Organism Mus musculus (Mouse).
Sequence Length 403
Subcellular Localization
Protein Description Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity)..
Protein Sequence MTSYSYRQTSAMSSFGGTGGGSVRIGSGGVFRAPSIHGGSGGRGVSVSSTRFVTSSSGSYGGVRGGSFSGTLAVSDGLLSGNEKITMQNLNDRLASYLDKVRALEQANGELEVKIRDWYQKQGPGPSRDYNHYFKTIEDLRDKILGATIDNSKIVLQIDNARLAADDFRTKFETEHALRLSVEADINGLRRVLDELTLARTDLEMQIESLKEELAYLKKNHEEEITALRSQVGGQVSVEVDSTPGVDLAKILSEMRSQYEIMAEKNRKDAEATYLARIEELNTQVAVHSEQIQISKTEVTDLRRTLQGLEIELQSQLSMKAALEGTLAETEARYGVQLSQIQSVISGFEAQLSDVRADIERQNQEYKQLMDIKSRLEQEIATYRSLLEGQEAHYNNLPTPKAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MTSYSYRQTS
-----CCCCCCCCCC		15.69-
7Methylation-MTSYSYRQTSAMSS
-CCCCCCCCCCCCCC		27.62-
10PhosphorylationSYSYRQTSAMSSFGG
CCCCCCCCCCCCCCC		17.4028973931
13PhosphorylationYRQTSAMSSFGGTGG
CCCCCCCCCCCCCCC		23.4126239621
14PhosphorylationRQTSAMSSFGGTGGG
CCCCCCCCCCCCCCC		18.1526239621
22PhosphorylationFGGTGGGSVRIGSGG
CCCCCCCCEEECCCC		16.1126239621
24Asymmetric dimethylarginineGTGGGSVRIGSGGVF
CCCCCCEEECCCCEE		29.28-
24MethylationGTGGGSVRIGSGGVF
CCCCCCEEECCCCEE		29.2812018447
27PhosphorylationGGSVRIGSGGVFRAP
CCCEEECCCCEEECC		29.9727180971
32MethylationIGSGGVFRAPSIHGG
ECCCCEEECCCCCCC		43.0924129315
35PhosphorylationGGVFRAPSIHGGSGG
CCEEECCCCCCCCCC		26.6626239621
40PhosphorylationAPSIHGGSGGRGVSV
CCCCCCCCCCCCCEE		42.5426239621
43MethylationIHGGSGGRGVSVSST
CCCCCCCCCCEEECE		45.9624129315
49PhosphorylationGRGVSVSSTRFVTSS
CCCCEEECEEEEEEC		22.8022871156
51MethylationGVSVSSTRFVTSSSG
CCEEECEEEEEECCC		26.4524129315
54PhosphorylationVSSTRFVTSSSGSYG
EECEEEEEECCCCCC		21.8526239621
55PhosphorylationSSTRFVTSSSGSYGG
ECEEEEEECCCCCCC		19.7326239621
56PhosphorylationSTRFVTSSSGSYGGV
CEEEEEECCCCCCCC		29.3826239621
57PhosphorylationTRFVTSSSGSYGGVR
EEEEEECCCCCCCCC		31.3726239621
59PhosphorylationFVTSSSGSYGGVRGG
EEEECCCCCCCCCCC		23.6626239621
60PhosphorylationVTSSSGSYGGVRGGS
EEECCCCCCCCCCCC		22.7926239621
64MethylationSGSYGGVRGGSFSGT
CCCCCCCCCCCCCEE		47.2124129315
67PhosphorylationYGGVRGGSFSGTLAV
CCCCCCCCCCEEEEE		21.0426239621
69PhosphorylationGVRGGSFSGTLAVSD
CCCCCCCCEEEEEEC		32.3426239621
71PhosphorylationRGGSFSGTLAVSDGL
CCCCCCEEEEEECCC		15.4526239621
75PhosphorylationFSGTLAVSDGLLSGN
CCEEEEEECCCCCCC		21.9826239621
86PhosphorylationLSGNEKITMQNLNDR
CCCCCEEEECCHHHH		24.6229899451
96PhosphorylationNLNDRLASYLDKVRA
CHHHHHHHHHHHHHH		30.71-
171UbiquitinationAADDFRTKFETEHAL
CCHHHHHHHHHHHHH		36.63-
219UbiquitinationEELAYLKKNHEEEIT
HHHHHHHHCCHHHHH		62.02-
315PhosphorylationGLEIELQSQLSMKAA
HHHHHHHHHHHHHHH		45.79-
326PhosphorylationMKAALEGTLAETEAR
HHHHHHCHHHHHHHH		17.27-
334PhosphorylationLAETEARYGVQLSQI
HHHHHHHHCCCHHHH		28.7926239621
385PhosphorylationQEIATYRSLLEGQEA
HHHHHHHHHHCHHHH		27.2227087446
394PhosphorylationLEGQEAHYNNLPTPK
HCHHHHHHCCCCCCC		16.8822817900
399PhosphorylationAHYNNLPTPKAI---
HHHCCCCCCCCC---		40.3627180971
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K1C19_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K1C19_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K1C19_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of K1C19_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K1C19_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Characterization of in vivo keratin 19 phosphorylation on tyrosine-391.";
Zhou Q., Snider N.T., Liao J., Li D.H., Hong A., Ku N.O.,Cartwright C.A., Omary M.B.;
PLoS ONE 5:E13538-E13538(2010).
Cited for: PHOSPHORYLATION AT TYR-394.

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