dbPTM

TBA1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBA1B_MOUSE
UniProt AC	P05213
Protein Name	Tubulin alpha-1B chain
Gene Name	Tuba1b
Organism	Mus musculus (Mouse).
Sequence Length	451
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
Protein Sequence	MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRECISIHVGQAG --CCCEEEEEECCHH	20.50	15345747
40	Acetylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	2736326
40	Ubiquitination	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	-
40	Methylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	12692561
41	Phosphorylation	GQMPSDKTIGGGDDS CCCCCCCCCCCCCCC	29.82	25521595
48	Phosphorylation	TIGGGDDSFNTFFSE CCCCCCCCHHHCCCC	25.74	25521595
51	Phosphorylation	GGDDSFNTFFSETGA CCCCCHHHCCCCCCC	24.85	24925903
54	Phosphorylation	DSFNTFFSETGAGKH CCHHHCCCCCCCCCC	30.02	25521595
56	Phosphorylation	FNTFFSETGAGKHVP HHHCCCCCCCCCCCC	31.00	25159016
60	Acetylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	19850273
60	Ubiquitination	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
73	Phosphorylation	VFVDLEPTVIDEVRT EEECCCCEEEHHCCC	22.25	22817900
80	Phosphorylation	TVIDEVRTGTYRQLF EEEHHCCCCCCHHCC	38.77	22006019
82	Phosphorylation	IDEVRTGTYRQLFHP EHHCCCCCCHHCCCH	18.21	26060331
83	Phosphorylation	DEVRTGTYRQLFHPE HHCCCCCCHHCCCHH	9.56	26060331
94	Phosphorylation	FHPEQLITGKEDAAN CCHHHHCCCCHHHHH	51.28	27600695
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	27667366
96	Acetylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	23201123
103	Phosphorylation	KEDAANNYARGHYTI CHHHHHHCCCCCCCC	9.48	22817900
108	Phosphorylation	NNYARGHYTIGKEII HHCCCCCCCCCHHHH	11.68	25195567
109	Phosphorylation	NYARGHYTIGKEIID HCCCCCCCCCHHHHH	19.99	26824392
112	Ubiquitination	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	-
124	Acetylation	LVLDRIRKLADQCTG HHHHHHHHHHHHCCC	45.73	156237
140	Ubiquitination	QGFLVFHSFGGGTGS CCEEEEEECCCCCCC	17.70	27667366
158	Phosphorylation	SLLMERLSVDYGKKS HHHHHHHCCCCCCCC	21.11	27180971
161	Phosphorylation	MERLSVDYGKKSKLE HHHHCCCCCCCCCEE	28.79	29472430
163	Acetylation	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	129189
163	Ubiquitination	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	27667366
163	Succinylation	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	23954790
164	Ubiquitination	LSVDYGKKSKLEFSI HCCCCCCCCCEEEEE	48.75	27667366
165	Phosphorylation	SVDYGKKSKLEFSIY CCCCCCCCCEEEEEE	46.06	-
166	Ubiquitination	VDYGKKSKLEFSIYP CCCCCCCCEEEEEEE	62.00	-
207	Ubiquitination	CAFMVDNEAIYDICR EEEEECHHHHHHHHH	31.79	27667366
208	Ubiquitination	AFMVDNEAIYDICRR EEEECHHHHHHHHHC	16.34	27667366
210	Phosphorylation	MVDNEAIYDICRRNL EECHHHHHHHHHCCC	13.30	22817900
223	Phosphorylation	NLDIERPTYTNLNRL CCCCCCCCHHCHHHH	49.55	22817900
224	Phosphorylation	LDIERPTYTNLNRLI CCCCCCCHHCHHHHH	9.05	22817900
225	Phosphorylation	DIERPTYTNLNRLIS CCCCCCHHCHHHHHH	35.39	22817900
232	Phosphorylation	TNLNRLISQIVSSIT HCHHHHHHHHHHHHH	20.60	26824392
236	Phosphorylation	RLISQIVSSITASLR HHHHHHHHHHHHHCC	20.04	23984901
237	Phosphorylation	LISQIVSSITASLRF HHHHHHHHHHHHCCC	17.05	23984901
271	Phosphorylation	RIHFPLATYAPVISA CCCCCCCCCCCCCCH	28.09	25159016
272	Phosphorylation	IHFPLATYAPVISAE CCCCCCCCCCCCCHH	11.87	25159016
277	Phosphorylation	ATYAPVISAEKAYHE CCCCCCCCHHHHHHH	30.52	25159016
277	O-linked_Glycosylation	ATYAPVISAEKAYHE CCCCCCCCHHHHHHH	30.52	20547045
280	Ubiquitination	APVISAEKAYHEQLS CCCCCHHHHHHHHCC	54.70	-
282	Nitrated tyrosine	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
282	Phosphorylation	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	26745281
282	Nitration	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
287	Phosphorylation	KAYHEQLSVAEITNA HHHHHHCCHHHHHHH	20.98	25521595
292	Phosphorylation	QLSVAEITNACFEPA HCCHHHHHHHHCCCH	14.31	23984901
295	S-nitrosocysteine	VAEITNACFEPANQM HHHHHHHHCCCHHHC	4.27	-
295	S-nitrosylation	VAEITNACFEPANQM HHHHHHHHCCCHHHC	4.27	19101475
304	Ubiquitination	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	-
311	Ubiquitination	KCDPRHGKYMACCLL CCCCCCCCEEEEHHH	26.23	-
315	S-nitrosocysteine	RHGKYMACCLLYRGD CCCCEEEEHHHCCCC	0.67	-
315	S-nitrosylation	RHGKYMACCLLYRGD CCCCEEEEHHHCCCC	0.67	20925432
316	S-nitrosocysteine	HGKYMACCLLYRGDV CCCEEEEHHHCCCCC	1.81	-
316	S-nitrosylation	HGKYMACCLLYRGDV CCCEEEEHHHCCCCC	1.81	24926564
319	Phosphorylation	YMACCLLYRGDVVPK EEEEHHHCCCCCCCC	10.29	22817900
326	Ubiquitination	YRGDVVPKDVNAAIA CCCCCCCCCHHHHHH	63.80	27667366
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCHHHHHH	63.80	23201123
334	Phosphorylation	DVNAAIATIKTKRSI CHHHHHHHCCCCCEE	19.52	26824392
336	Ubiquitination	NAAIATIKTKRSIQF HHHHHHCCCCCEEEE	43.57	27667366
337	Phosphorylation	AAIATIKTKRSIQFV HHHHHCCCCCEEEEE	28.04	26745281
338	Ubiquitination	AIATIKTKRSIQFVD HHHHCCCCCEEEEEE	38.86	-
339	Methylation	IATIKTKRSIQFVDW HHHCCCCCEEEEEEE	44.20	-
340	Phosphorylation	ATIKTKRSIQFVDWC HHCCCCCEEEEEEEC	23.46	25521595
347	S-nitrosocysteine	SIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	-
347	Glutathionylation	SIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	24333276
347	S-nitrosylation	SIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	22588120
347	S-palmitoylation	SIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	28526873
349	Phosphorylation	QFVDWCPTGFKVGIN EEEEECCCCEEEEEE	52.71	25159016
352	Acetylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	69933
352	Ubiquitination	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	-
357	Phosphorylation	GFKVGINYQPPTVVP CEEEEEECCCCEECC	22.07	25521595
361	Phosphorylation	GINYQPPTVVPGGDL EEECCCCEECCCCCH	40.60	25159016
370	Ubiquitination	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	27667366
376	S-nitrosocysteine	AKVQRAVCMLSNTTA HHHHHHHHHHCCHHH	1.90	-
376	S-nitrosylation	AKVQRAVCMLSNTTA HHHHHHHHHHCCHHH	1.90	20925432
376	S-palmitoylation	AKVQRAVCMLSNTTA HHHHHHHHHHCCHHH	1.90	28526873
379	Phosphorylation	QRAVCMLSNTTAIAE HHHHHHHCCHHHHHH	12.78	22817900
380	Ubiquitination	RAVCMLSNTTAIAEA HHHHHHCCHHHHHHH	37.17	27667366
381	Phosphorylation	AVCMLSNTTAIAEAW HHHHHCCHHHHHHHH	17.77	23984901
382	Phosphorylation	VCMLSNTTAIAEAWA HHHHCCHHHHHHHHH	21.95	23984901
394	Ubiquitination	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	27667366
394	Succinylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	23954790
399	Phosphorylation	DHKFDLMYAKRAFVH CCCCCHHHEEEHHHH	19.10	26745281
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	129185
401	Ubiquitination	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	27667366
401	Succinylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	23954790
408	Phosphorylation	KRAFVHWYVGEGMEE EEHHHHHHCCCCCCC	5.45	25777480
414	Ubiquitination	WYVGEGMEEGEFSEA HHCCCCCCCCCHHHH	73.95	27667366
419	Phosphorylation	GMEEGEFSEAREDMA CCCCCCHHHHHHHHH	26.50	22817900
432	Phosphorylation	MAALEKDYEEVGVDS HHHHHHCHHHHCCCC	25.67	25619855
438	Ubiquitination	DYEEVGVDSVEGEGE CHHHHCCCCCCCCCC	40.82	27667366
439	Phosphorylation	YEEVGVDSVEGEGEE HHHHCCCCCCCCCCC	21.47	25521595
445	5-glutamyl polyglutamate	DSVEGEGEEEGEEY- CCCCCCCCCCCCCC-	48.88	-
445	Ubiquitination	DSVEGEGEEEGEEY- CCCCCCCCCCCCCC-	48.88	27667366
445	Formation of an isopeptide bond	DSVEGEGEEEGEEY- CCCCCCCCCCCCCC-	48.88	1967194
451	Phosphorylation	GEEEGEEY------- CCCCCCCC-------	21.39	25619855
451	Nitration	GEEEGEEY------- CCCCCCCC-------	21.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TBA1B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
40	K	Acetylation	19564401
Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen.
40	K	Methylation	-
Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBA1B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DNJA1_HUMAN	DNAJA1	physical	20360068

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBA1B_MOUSE

Related Literatures of Post-Translational Modification

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