VATH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATH_MOUSE
• UniProt AC: Q8BVE3
• Protein Name: V-type proton ATPase subunit H
• Gene Name: Atp6v1h
• Organism: Mus musculus (Mouse).
• Sequence Length: 483
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity)..
• Protein Sequence: MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSSEDKQEMLQTEGSQCAKTFINLMTHISKEQTVQYILTMVDDMLQENHQRVSIFFDYAKRSKSTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTISSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	S-palmitoylation	QMISAEDCEFIQRFE CCCCHHHHHHHHHHC	3.28	28680068
58	Phosphorylation	QRFEMKRSSEDKQEM HHHCCCCCCHHHHHH	32.34	19060867
59	Phosphorylation	RFEMKRSSEDKQEML HHCCCCCCHHHHHHH	54.57	25521595
73	S-nitrosocysteine	LQTEGSQCAKTFINL HHCCHHHHHHHHHHH	4.49	-
73	S-nitrosylation	LQTEGSQCAKTFINL HHCCHHHHHHHHHHH	4.49	21278135
85	Phosphorylation	INLMTHISKEQTVQY HHHHHHCCHHHHHHH	23.64	25521595
325	Ubiquitination	LENLEQQKYDDEDIS HHCHHHCCCCCCCHH	50.79	22790023
350	Phosphorylation	GESVQDLSSFDEYSS CHHHHHHHCHHHHHH	36.93	29899451
351	Phosphorylation	ESVQDLSSFDEYSSE HHHHHHHCHHHHHHH	43.97	29899451
371	Acetylation	LEWSPVHKSEKFWRE CCCCCCCCCHHHHHH	61.62	22902405
374	Acetylation	SPVHKSEKFWRENAV CCCCCCHHHHHHHCH	58.27	22902405
386	Acetylation	NAVRLNEKNYELLKI HCHHHCHHHHHHHHH	64.85	22902405
388	Phosphorylation	VRLNEKNYELLKILT HHHCHHHHHHHHHHH	21.01	25367039
392	Acetylation	EKNYELLKILTKLLE HHHHHHHHHHHHHHH	48.58	22902405
392	Ubiquitination	EKNYELLKILTKLLE HHHHHHHHHHHHHHH	48.58	22790023
396	Ubiquitination	ELLKILTKLLEVSDD HHHHHHHHHHHCCCC	47.86	22790023
417	Nitration	AAHDVGEYVRHYPRG EECHHHHHHHHCCCC	9.24	-
469	Ubiquitination	HNWEYLGKQLQSEQP CCHHHHHHHHHCCCC	45.28	22790023
473	Phosphorylation	YLGKQLQSEQPQTAA HHHHHHHCCCCCCHH	46.95	28066266
478	Phosphorylation	LQSEQPQTAAARS-- HHCCCCCCHHHCC--	25.58	25521595
483	Phosphorylation	PQTAAARS------- CCCHHHCC-------	39.59	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VATH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.