STS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STS_MOUSE
• UniProt AC: P50427
• Protein Name: Steryl-sulfatase
• Gene Name: Sts
• Organism: Mus musculus (Mouse).
• Sequence Length: 624
• Subcellular Localization: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein . The sequence shows several membrane-spanning domains that could serve to anchor the protein in the microsomal membrane.
• Protein Description: Conversion of sulfated steroid precursors to estrogens during pregnancy..
• Protein Sequence: MPRPRPLLLAVMAATLADIILAADPAPAGPAPRPPNFLLIMADDLGIGDLGCYGNKTLRTPHLDRLAREGVKLTQHLAAAPLCTPSRAAFLTGRYPPRSGMAAHGRVGVYLFTASSGGLPPSEVTMARLLKGRGYATALIGKWHLGLSCRGATDFCHHPLRHGFDRFLGVPTTNLRDCRPGAGTVFGPALRVFAAGPLAALGASLAAMAAARWAGLARVPGWALAGTAAAMLAVGGPRSASCLGFRPANCFLMDDLAVAQRPTDYGGLTRRLADEAALFLRRNRARPFLLFLSFLHVHTAHFADPGFAGRSLHGAYGDSVEEMDWGVGRVLAALDELGLARETLVYFTSDHGAHVEELGPRGERMGGSNGVFRGGKGNNWEGGVRVPCLVRWPRELSPGRVVAEPTSLMDVFPTVARLAGAELPGDRVIDGRDLMPLLRGDAQRSEHEFLFHYCNAYLQAVRWHNGSAVWKAFYFTPNFAPAGANGCFSTHVCLCAGPAHVTAHDPPLLFDLTRDPGERRPLTPEAEPRHREVLDAIDAAARAHRARLRPAPDQLAPRHLMWKPWLQLWGGGGAGGGAGAQDDSGHAHGDGSHAHDDPGHAQDRGDDDAHYGGHATTRTQATPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	N-linked_Glycosylation	GDLGCYGNKTLRTPH CCCCCCCCCCCCCHH	13.99	-
83	3-oxoalanine (Cys)	HLAAAPLCTPSRAAF HHHHCCCCCCCHHHH	5.24	-
83	Oxidation	HLAAAPLCTPSRAAF HHHHCCCCCCCHHHH	5.24	-
178	S-palmitoylation	PTTNLRDCRPGAGTV CCCCHHHCCCCCCCC	4.58	26165157
376	Ubiquitination	NGVFRGGKGNNWEGG CCCCCCCCCCCCCCC	62.38	22790023
465	N-linked_Glycosylation	LQAVRWHNGSAVWKA HHHHHCCCCCEEEEE	38.87	-
523	Phosphorylation	PGERRPLTPEAEPRH CCCCCCCCCCCCHHH	23.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.