UN45B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UN45B_MOUSE
• UniProt AC: Q8CGY6
• Protein Name: Protein unc-45 homolog B
• Gene Name: Unc45b
• Organism: Mus musculus (Mouse).
• Sequence Length: 931
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. [PubMed: 12356907]
• Protein Sequence: MAEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQLRVQFSTDSRVQTMFEILLNENSEADKREKAANNLIVLGREEAGAERIFQSNGVALLLQLMNTQRPELLLAAVRTLSGMCSGHRARATAILHAVRIDRICSLMALENEEMSLAVCNLLQAIIDSLSGEDKREHRGKEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLSIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITSKFDPQDMDKNVNAIQTVSGILQGPFDLGNQLLGMKGVMEMMVALCGSEREADQLVAVEALIHASTKLSRATFIITNGVTLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGSDYGLRQFAEGSTEKLAKQCRKWLCNTAIDTRTRRWAVEGLAYLTLDADVKDDFVQDIPALQAMFELAKARTSDKTILYSVANTLVNCTNSYDVKEVVPELVQLAKFSKQHVPEEHPKDKKDFVDLRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHGLAKIAAVSNPDIAFPGERVYEVVRPLVSLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKEKALPDIENYMFENHDQLRQAATECMCNMVLNKEVQERFLADGNDRLKLVVLLCGEDDHKLQNAAAGALAMLTAAHKKLCLKMTEVTTQWLEILQRLCLHDQLSVQHRGLVIAHNLLSADAELARKLVESELLEILTVVGKQEPDEKRAAVVQTARECLIKCMDYGFIKPVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	ALKLTKDKALLATLY HHHHCCCHHHHHHHH	42.35	22790023
44	Phosphorylation	KDKALLATLYRNRAA CCHHHHHHHHHCHHH	25.04	24899341
81	Phosphorylation	SADIKALYRRCQALE HHHHHHHHHHHHHHH	10.81	-
133	Phosphorylation	EQLRVQFSTDSRVQT HHHHHCCCCCHHHHH	17.76	-
519	S-nitrosocysteine	KQCRKWLCNTAIDTR HHHHHHHCCCCCCHH	4.06	-
519	S-nitrosylation	KQCRKWLCNTAIDTR HHHHHHHCCCCCCHH	4.06	21278135
600	Ubiquitination	PELVQLAKFSKQHVP HHHHHHHHHHHCCCC	59.78	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UN45B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UN45B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UN45B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HACE1_HUMAN	HACE1	physical	24614889

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.