| UniProt ID | HACE1_HUMAN | |
|---|---|---|
| UniProt AC | Q8IYU2 | |
| Protein Name | E3 ubiquitin-protein ligase HACE1 | |
| Gene Name | HACE1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 909 | |
| Subcellular Localization | Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins. | |
| Protein Description | E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.. | |
| Protein Sequence | MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKRDSTEITSILLKQKGQDQDAASIPPFEPPGPGSYENLSTGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | QLNRLTRSLRRARTV HHHHHHHHHHHHCCC | 22.46 | - | |
| 20 | Phosphorylation | RSLRRARTVELPEDN HHHHHHCCCCCCCCC | 19.83 | 22199227 | |
| 29 | Phosphorylation | ELPEDNETAVYTLMP CCCCCCCCHHHHHHH | 27.90 | 22199227 | |
| 32 | Phosphorylation | EDNETAVYTLMPMVM CCCCCHHHHHHHHHH | 7.53 | 22199227 | |
| 33 | Phosphorylation | DNETAVYTLMPMVMA CCCCHHHHHHHHHHH | 15.24 | 22199227 | |
| 124 | Phosphorylation | LLEYSADVNICNNEG HHHHHCCCEECCCCC | 5.34 | 32645325 | |
| 191 | Phosphorylation | LDSGADINRPNVSGA CCCCCCCCCCCCCCC | 54.63 | 32645325 | |
| 217 | Phosphorylation | RDTAQILLLRGAKYL CCHHHHHHHCCCCCC | 3.07 | 32645325 | |
| 223 | Phosphorylation | LLLRGAKYLPDKNGV HHHCCCCCCCCCCCC | 23.96 | 32645325 | |
| 288 | Phosphorylation | SQQSESQYLKILTSL HHCCHHHHHHHHHHH | 21.17 | 32645325 | |
| 307 | Phosphorylation | TTNGHKLLSLSSNYD HCCCCHHEECCCCHH | 6.04 | 32645325 | |
| 319 | Phosphorylation | NYDAQMKSLLRIVRM CHHHHHHHHHHHHHH | 27.56 | 24719451 | |
| 336 | Phosphorylation | HVFRIGPSSPSNGID HHHCCCCCCCCCCCC | 50.06 | 25850435 | |
| 337 | Phosphorylation | VFRIGPSSPSNGIDM HHCCCCCCCCCCCCC | 35.17 | 25850435 | |
| 339 | Phosphorylation | RIGPSSPSNGIDMGY CCCCCCCCCCCCCCC | 50.03 | 25850435 | |
| 341 | Phosphorylation | GPSSPSNGIDMGYNG CCCCCCCCCCCCCCC | 22.93 | 32645325 | |
| 351 | Phosphorylation | MGYNGNKTPRSQVFK CCCCCCCCCHHHCCH | 28.12 | 32645325 | |
| 385 | Phosphorylation | LMKNKRDSTEITSIL HHHCCCCHHHHHHHH | 31.79 | 30266825 | |
| 386 | Phosphorylation | MKNKRDSTEITSILL HHCCCCHHHHHHHHH | 35.38 | 30266825 | |
| 389 | Phosphorylation | KRDSTEITSILLKQK CCCHHHHHHHHHHHC | 11.95 | 29255136 | |
| 390 | Phosphorylation | RDSTEITSILLKQKG CCHHHHHHHHHHHCC | 19.53 | 21712546 | |
| 415 | Phosphorylation | FEPPGPGSYENLSTG CCCCCCCCCCCCCCC | 32.19 | 28796482 | |
| 416 | Phosphorylation | EPPGPGSYENLSTGT CCCCCCCCCCCCCCC | 18.10 | 28796482 | |
| 420 | Phosphorylation | PGSYENLSTGTRESK CCCCCCCCCCCCCCC | 36.05 | 28796482 | |
| 421 | Phosphorylation | GSYENLSTGTRESKP CCCCCCCCCCCCCCC | 45.82 | 28796482 | |
| 423 | Phosphorylation | YENLSTGTRESKPDA CCCCCCCCCCCCCCH | 31.21 | 28796482 | |
| 513 | Phosphorylation | LECPELMSRFMHIIK HHCHHHHHHHHHHHH | 34.68 | - | |
| 520 | Acetylation | SRFMHIIKAQPFKDR HHHHHHHHCCCCHHH | 40.13 | 12431651 | |
| 661 | Phosphorylation | HRQLVNIYFTRSFYK HHHHHHEEEHHHHHH | 8.16 | - | |
| 677 | Phosphorylation | ILGIPVNYQDVASID HHCCCCCHHHHHCCC | 13.31 | - | |
| 687 | Phosphorylation | VASIDPEYAKNLQWI HHCCCHHHHHHCHHH | 28.41 | - | |
| 888 | Trimethylation | KLPEYPSKEILKDRL CCCCCCCHHHHHHHH | 44.24 | - | |
| 888 | Methylation | KLPEYPSKEILKDRL CCCCCCCHHHHHHHH | 44.24 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HACE1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HACE1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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