TCPQ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPQ_MOUSE
• UniProt AC: P42932
• Protein Name: T-complex protein 1 subunit theta
• Gene Name: Cct8
• Organism: Mus musculus (Mouse).
• Sequence Length: 548
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body .
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity)..
• Protein Sequence: MALHVPKAPGFAQMLKDGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINRLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVISGYEIACKKAHEILPELVCCSAKNLRDVDEVSSLLRTSIMSKQYGSETFLAKLIAQACVSIFPDSGNFNVDNIRVCKILGSGIYSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAGTGANVIVTGGKVADIALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPKLTPPVQEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYSVHQEGNKNVGLDIEAEVPAVKDMLEASILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDDQND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALHVPKAP ------CCCCCCCCC	13.33	-
7	Acetylation	-MALHVPKAPGFAQM -CCCCCCCCCCHHHH	67.15	22826441
7	Ubiquitination	-MALHVPKAPGFAQM -CCCCCCCCCCHHHH	67.15	-
16	Acetylation	PGFAQMLKDGAKHFS CCHHHHHHHHHHHCC	49.09	23806337
16	Ubiquitination	PGFAQMLKDGAKHFS CCHHHHHHHHHHHCC	49.09	-
16	Malonylation	PGFAQMLKDGAKHFS CCHHHHHHHHHHHCC	49.09	26320211
20	Ubiquitination	QMLKDGAKHFSGLEE HHHHHHHHHCCCHHH	51.19	-
20	Acetylation	QMLKDGAKHFSGLEE HHHHHHHHHCCCHHH	51.19	22826441
20	Malonylation	QMLKDGAKHFSGLEE HHHHHHHHHCCCHHH	51.19	26320211
23	Phosphorylation	KDGAKHFSGLEEAVY HHHHHHCCCHHHHHH	42.03	21082442
30	Phosphorylation	SGLEEAVYRNIQACK CCHHHHHHHHHHHHH	12.65	25263469
36	Glutathionylation	VYRNIQACKELAQTT HHHHHHHHHHHHHHH	1.70	24333276
37	Acetylation	YRNIQACKELAQTTR HHHHHHHHHHHHHHC	59.80	22826441
45	Phosphorylation	ELAQTTRTAYGPNGM HHHHHHCHHHCCCHH	23.34	22817900
47	Phosphorylation	AQTTRTAYGPNGMNK HHHHCHHHCCCHHHH	32.28	22817900
62	Acetylation	MVINRLEKLFVTNDA HHHHHHHHHHCCCCH	52.39	23236377
62	Ubiquitination	MVINRLEKLFVTNDA HHHHHHHHHHCCCCH	52.39	-
148	Glutathionylation	EILPELVCCSAKNLR HHHHHHHHCCCCCCC	2.07	24333276
148	S-nitrosylation	EILPELVCCSAKNLR HHHHHHHHCCCCCCC	2.07	20925432
148	S-nitrosocysteine	EILPELVCCSAKNLR HHHHHHHHCCCCCCC	2.07	-
149	Glutathionylation	ILPELVCCSAKNLRD HHHHHHHCCCCCCCC	3.27	24333276
161	Phosphorylation	LRDVDEVSSLLRTSI CCCHHHHHHHHHHHH	17.14	21743459
162	Phosphorylation	RDVDEVSSLLRTSIM CCHHHHHHHHHHHHH	36.28	21743459
171	Acetylation	LRTSIMSKQYGSETF HHHHHHHCCCCCHHH	30.11	22826441
175	Phosphorylation	IMSKQYGSETFLAKL HHHCCCCCHHHHHHH	28.64	29514104
206	Acetylation	VDNIRVCKILGSGIY CCCEEEEEEECCCCC	37.80	22826441
210	Phosphorylation	RVCKILGSGIYSSSV EEEEEECCCCCCCCC	20.69	22345495
213	Phosphorylation	KILGSGIYSSSVLHG EEECCCCCCCCCEEE	13.16	22345495
214	Phosphorylation	ILGSGIYSSSVLHGM EECCCCCCCCCEEEE	17.76	22345495
215	Phosphorylation	LGSGIYSSSVLHGMV ECCCCCCCCCEEEEE	13.90	22345495
216	Phosphorylation	GSGIYSSSVLHGMVF CCCCCCCCCEEEEEE	23.82	22345495
224	Acetylation	VLHGMVFKKETEGDV CEEEEEEECCCCCCC	37.99	22826441
233	Phosphorylation	ETEGDVTSVKDAKIA CCCCCCCCCCCCEEE	27.33	26824392
235	Ubiquitination	EGDVTSVKDAKIAVY CCCCCCCCCCEEEEE	52.30	-
235	Succinylation	EGDVTSVKDAKIAVY CCCCCCCCCCEEEEE	52.30	23954790
244	Glutathionylation	AKIAVYSCPFDGMIT CEEEEEECCCCCCEE	1.82	24333276
244	S-nitrosylation	AKIAVYSCPFDGMIT CEEEEEECCCCCCEE	1.82	24926564
244	S-palmitoylation	AKIAVYSCPFDGMIT CEEEEEECCCCCCEE	1.82	28526873
254	Ubiquitination	DGMITETKGTVLIKT CCCEECCCCEEEEEC	46.48	-
260	Acetylation	TKGTVLIKTAEELMN CCCEEEEECHHHHHC	37.21	22826441
260	Ubiquitination	TKGTVLIKTAEELMN CCCEEEEECHHHHHC	37.21	-
269	Phosphorylation	AEELMNFSKGEENLM HHHHHCCCCCCCCHH	34.44	27841257
270	Ubiquitination	EELMNFSKGEENLMD HHHHCCCCCCCCHHH	67.23	-
281	Ubiquitination	NLMDAQVKAIAGTGA CHHHHHHHHHHCCCC	23.22	-
296	Ubiquitination	NVIVTGGKVADIALH EEEEECCCHHHHHHH	35.28	-
304	Phosphorylation	VADIALHYANKYNIM HHHHHHHHHHHCCEE	16.84	25367039
317	Phosphorylation	IMLVRLNSKWDLRRL EEEEECCCHHHHHHH	39.45	30372032
318	Malonylation	MLVRLNSKWDLRRLC EEEECCCHHHHHHHH	43.59	26320211
318	Acetylation	MLVRLNSKWDLRRLC EEEECCCHHHHHHHH	43.59	23864654
326	Acetylation	WDLRRLCKTVGATAL HHHHHHHHHHCCCCC	51.33	23806337
326	Succinylation	WDLRRLCKTVGATAL HHHHHHHHHHCCCCC	51.33	23806337
326	Malonylation	WDLRRLCKTVGATAL HHHHHHHHHHCCCCC	51.33	26320211
327	Phosphorylation	DLRRLCKTVGATALP HHHHHHHHHCCCCCC	24.15	-
367	Acetylation	VVVFKHEKEDGAIST EEEEEEECCCCCEEE	61.91	23806337
367	Ubiquitination	VVVFKHEKEDGAIST EEEEEEECCCCCEEE	61.91	-
380	Phosphorylation	STIVLRGSTDNLMDD EEEEEECCCCCHHHH	26.59	22006019
381	Phosphorylation	TIVLRGSTDNLMDDI EEEEECCCCCHHHHH	31.56	28066266
400	Ubiquitination	DDGVNTFKVLTRDKR HCCCCEEEEEECCCC	34.01	-
400	Malonylation	DDGVNTFKVLTRDKR HCCCCEEEEEECCCC	34.01	26320211
400	Acetylation	DDGVNTFKVLTRDKR HCCCCEEEEEECCCC	34.01	23806337
400	Succinylation	DDGVNTFKVLTRDKR HCCCCEEEEEECCCC	34.01	23806337
421	Ubiquitination	ATEIELAKQITSYGE HHHHHHHHHHHHCCC	55.66	-
430	Glutathionylation	ITSYGETCPGLEQYA HHHCCCCCCCHHHHH	1.88	24333276
430	S-nitrosylation	ITSYGETCPGLEQYA HHHCCCCCCCHHHHH	1.88	24926564
440	Ubiquitination	LEQYAIKKFAEAFEA HHHHHHHHHHHHHHH	43.63	-
459	Succinylation	LAENSGVKANEVISK HHHCCCCCHHHHHHH	49.36	23954790
459	Ubiquitination	LAENSGVKANEVISK HHHCCCCCHHHHHHH	49.36	-
466	Acetylation	KANEVISKLYSVHQE CHHHHHHHHHHHHHC	40.08	22826441
505	Phosphorylation	LDTYLGKYWAIKLAT HHHHHHHHHHHHHHH	9.77	-
528	Malonylation	VDQIIMAKPAGGPKP ECEEEEECCCCCCCC	20.30	26320211
528	Ubiquitination	VDQIIMAKPAGGPKP ECEEEEECCCCCCCC	20.30	-
534	Malonylation	AKPAGGPKPPSGKKD ECCCCCCCCCCCCCC	73.22	26320211
534	Ubiquitination	AKPAGGPKPPSGKKD ECCCCCCCCCCCCCC	73.22	-
537	Phosphorylation	AGGPKPPSGKKDWDD CCCCCCCCCCCCCCC	72.30	26824392
539	Ubiquitination	GPKPPSGKKDWDDDQ CCCCCCCCCCCCCCC	52.47	-
540	Ubiquitination	PKPPSGKKDWDDDQN CCCCCCCCCCCCCCC	68.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPQ_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPQ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPQ_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPZ_HUMAN	CCT6A	physical	26496610
CSTF1_HUMAN	CSTF1	physical	26496610
DHX15_HUMAN	DHX15	physical	26496610
TNPO1_HUMAN	TNPO1	physical	26496610
PHLP_HUMAN	PDCL	physical	26496610
PFD2_HUMAN	PFDN2	physical	26496610
PPP6_HUMAN	PPP6C	physical	26496610
GTR1_HUMAN	SLC2A1	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
EIF3I_HUMAN	EIF3I	physical	26496610
PDCD5_HUMAN	PDCD5	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
TXND9_HUMAN	TXNDC9	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
AT132_HUMAN	ATP13A2	physical	26496610
NDUAD_HUMAN	NDUFA13	physical	26496610
HGH1_HUMAN	HGH1	physical	26496610
DTL_HUMAN	DTL	physical	26496610
TMCO1_HUMAN	TMCO1	physical	26496610
RFWD3_HUMAN	RFWD3	physical	26496610
NCLN_HUMAN	NCLN	physical	26496610
LST8_HUMAN	MLST8	physical	26496610
PDCL3_HUMAN	PDCL3	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610
K2013_HUMAN	KIAA2013	physical	26496610
ESCO1_HUMAN	ESCO1	physical	26496610
TBB5_HUMAN	TUBB	physical	26496610
WDR92_HUMAN	WDR92	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.