| UniProt ID | LIMA1_MOUSE | |
|---|---|---|
| UniProt AC | Q9ERG0 | |
| Protein Name | LIM domain and actin-binding protein 1 | |
| Gene Name | Lima1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 753 | |
| Subcellular Localization | Cytoplasm. Cytoplasm, cytoskeleton. This cytoskeletal protein colocalizes with actin stress fibers. | |
| Protein Description | Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity).. | |
| Protein Sequence | MESTPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEEANMERKKNNPESLPQHFRRGTLSVLKKKWENPVAGAEFHTDSLPNSSSEGGHTADYPPAEVTDKPAPGVRADREEHTQPKPRFGSRPEAVIQSRYPRSENSHDFKAQATESQKMENCLGDSRHEAEKPETSENTETSGKIEKYNVPLNRLKMMFEKGEHNQTKSLWTQSRNAGGRRLSENNCSLDDWEIGAGHLSSSAFNSEKNESKRNLELPRLSETSIKDRMAKYQAAVSKQSSPASYTNELKTSESKTHKWEQKENVPPGPEACSVHQEGSKVSTTENSLVALSVPAEDDTCNSQVKSEAQQPMHPKPLSPDARTSSLPESSPSKTAKKFQAPAKESCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHKQHKDLWASKSDNEETLGRPAQPPNAGESPHSPGVEDAPIAKVGVLAASMEAKASSQREREDKPAETKKLRIAWPPPAELGGSGSALEEGIKVSKPKWPPEDDVCKTEAPEDVDLDLKKLRRSSSLKERSRPFTVAASFRTSSIKSPKASSPSLRKGWSESEQSEEFGGGIATMERKQTENARPSGEKENVGKSRWQGEEVPRSKDRSSFELESENFMENGANIAEDDNHVHAQQSPLEPEAPGWSGFVDTTAAKEFTTQNQKSQDVGFWEGEVVRELSVEEQIKRNRYYDEDEDEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MESTPFNR -------CCCCCCCH | 9.18 | - | |
| 12 | Phosphorylation | PFNRRQWTSLSLRVT CCCHHHCHHEEEEEE | 16.08 | 26745281 | |
| 13 | Phosphorylation | FNRRQWTSLSLRVTA CCHHHCHHEEEEEEH | 17.01 | 29895711 | |
| 15 | Phosphorylation | RRQWTSLSLRVTAKE HHHCHHEEEEEEHHH | 17.56 | 27087446 | |
| 21 | Malonylation | LSLRVTAKELSLVNK EEEEEEHHHHHHHCC | 50.23 | 26320211 | |
| 59 | Phosphorylation | RKKNNPESLPQHFRR HHHCCHHHHCHHHHH | 46.75 | 22324799 | |
| 65 (in isoform 2) | Phosphorylation | - | 33.71 | 19144319 | |
| 68 | Phosphorylation | PQHFRRGTLSVLKKK CHHHHHCHHHHHHHH | 17.66 | 22324799 | |
| 70 | Phosphorylation | HFRRGTLSVLKKKWE HHHHCHHHHHHHHHC | 25.82 | 30352176 | |
| 132 | Phosphorylation | QPKPRFGSRPEAVIQ CCCCCCCCCCHHHHH | 41.78 | 26643407 | |
| 140 | Phosphorylation | RPEAVIQSRYPRSEN CCHHHHHCCCCCCCC | 23.74 | 29472430 | |
| 148 | Phosphorylation | RYPRSENSHDFKAQA CCCCCCCCCCHHHHH | 22.00 | 27841257 | |
| 181 | Phosphorylation | KPETSENTETSGKIE CCCCCCCCCCCCEEE | 36.27 | 25195567 | |
| 189 | Acetylation | ETSGKIEKYNVPLNR CCCCEEEECCCCHHH | 45.67 | 23806337 | |
| 190 | Phosphorylation | TSGKIEKYNVPLNRL CCCEEEECCCCHHHH | 14.49 | 29514104 | |
| 225 | Phosphorylation | NAGGRRLSENNCSLD CCCCCCCCCCCCCCC | 36.14 | 25521595 | |
| 230 | Phosphorylation | RLSENNCSLDDWEIG CCCCCCCCCCCCCCC | 36.64 | 27087446 | |
| 242 | Phosphorylation | EIGAGHLSSSAFNSE CCCCCCCCCHHHCCC | 19.30 | 25619855 | |
| 243 | Phosphorylation | IGAGHLSSSAFNSEK CCCCCCCCHHHCCCC | 31.85 | 25619855 | |
| 244 | Phosphorylation | GAGHLSSSAFNSEKN CCCCCCCHHHCCCCC | 33.24 | 25619855 | |
| 248 | Phosphorylation | LSSSAFNSEKNESKR CCCHHHCCCCCHHHC | 43.42 | 25619855 | |
| 253 | Phosphorylation | FNSEKNESKRNLELP HCCCCCHHHCCCCCC | 46.43 | 29514104 | |
| 263 | Phosphorylation | NLELPRLSETSIKDR CCCCCCCCHHCHHHH | 39.86 | 26824392 | |
| 265 | Phosphorylation | ELPRLSETSIKDRMA CCCCCCHHCHHHHHH | 32.17 | 29176673 | |
| 266 | Phosphorylation | LPRLSETSIKDRMAK CCCCCHHCHHHHHHH | 24.48 | 29514104 | |
| 268 | Ubiquitination | RLSETSIKDRMAKYQ CCCHHCHHHHHHHHH | 38.76 | - | |
| 273 | Malonylation | SIKDRMAKYQAAVSK CHHHHHHHHHHHHHC | 28.66 | 26320211 | |
| 282 | Phosphorylation | QAAVSKQSSPASYTN HHHHHCCCCCCHHHH | 41.86 | 25619855 | |
| 283 | Phosphorylation | AAVSKQSSPASYTNE HHHHCCCCCCHHHHC | 23.22 | 25619855 | |
| 286 | Phosphorylation | SKQSSPASYTNELKT HCCCCCCHHHHCCCC | 35.55 | 25619855 | |
| 287 | Phosphorylation | KQSSPASYTNELKTS CCCCCCHHHHCCCCC | 18.72 | 29514104 | |
| 326 | O-linked_Glycosylation | EGSKVSTTENSLVAL CCCCEECCCCCEEEE | 26.18 | 28528544 | |
| 328 (in isoform 2) | Phosphorylation | - | 38.25 | 19144319 | |
| 348 | Phosphorylation | TCNSQVKSEAQQPMH CCCHHHCHHCCCCCC | 39.03 | 25619855 | |
| 360 | Phosphorylation | PMHPKPLSPDARTSS CCCCCCCCCCCCCCC | 29.30 | 25521595 | |
| 365 | Phosphorylation | PLSPDARTSSLPESS CCCCCCCCCCCCCCC | 25.12 | 30635358 | |
| 366 | Phosphorylation | LSPDARTSSLPESSP CCCCCCCCCCCCCCC | 25.07 | 30635358 | |
| 367 | Phosphorylation | SPDARTSSLPESSPS CCCCCCCCCCCCCCC | 47.53 | 26824392 | |
| 371 | Phosphorylation | RTSSLPESSPSKTAK CCCCCCCCCCCHHHH | 45.68 | 27087446 | |
| 372 | Phosphorylation | TSSLPESSPSKTAKK CCCCCCCCCCHHHHH | 31.37 | 25521595 | |
| 374 | Phosphorylation | SLPESSPSKTAKKFQ CCCCCCCCHHHHHHC | 44.58 | 22942356 | |
| 376 | Phosphorylation | PESSPSKTAKKFQAP CCCCCCHHHHHHCCC | 48.31 | 24068923 | |
| 396 | Phosphorylation | VECQKTVYPMERLLA HHHHCHHCCHHHHHC | 11.33 | - | |
| 412 | S-palmitoylation | QQVFHISCFRCSYCN CCEEEEEEEECCCCC | 2.17 | 26165157 | |
| 427 | Phosphorylation | NKLSLGTYASLHGRI CEEEECCCHHHCCEE | 7.75 | 29514104 | |
| 437 | Acetylation | LHGRIYCKPHFNQLF HCCEEEECHHHHHHH | 25.26 | 23806337 | |
| 437 | Succinylation | LHGRIYCKPHFNQLF HCCEEEECHHHHHHH | 25.26 | 23806337 | |
| 437 | Succinylation | LHGRIYCKPHFNQLF HCCEEEECHHHHHHH | 25.26 | - | |
| 450 | Phosphorylation | LFKSKGNYDEGFGHK HHHCCCCCCCCCCCC | 24.84 | 29514104 | |
| 465 | Phosphorylation | QHKDLWASKSDNEET CHHHHHCCCCCCCCC | 22.55 | 27087446 | |
| 467 | Phosphorylation | KDLWASKSDNEETLG HHHHCCCCCCCCCCC | 43.08 | 27087446 | |
| 472 | Phosphorylation | SKSDNEETLGRPAQP CCCCCCCCCCCCCCC | 28.47 | 20469934 | |
| 485 | Phosphorylation | QPPNAGESPHSPGVE CCCCCCCCCCCCCCC | 27.31 | 25521595 | |
| 488 | Phosphorylation | NAGESPHSPGVEDAP CCCCCCCCCCCCCCC | 27.08 | 27087446 | |
| 505 | Phosphorylation | KVGVLAASMEAKASS HHHHHHHHHHHHHHH | 16.14 | 26643407 | |
| 539 | Phosphorylation | PPAELGGSGSALEEG CCHHHCCCCHHHHCC | 27.98 | 30352176 | |
| 541 | Phosphorylation | AELGGSGSALEEGIK HHHCCCCHHHHCCCC | 31.23 | 23140645 | |
| 579 | Phosphorylation | DLKKLRRSSSLKERS CHHHHHCCCCHHHCC | 20.18 | 20688971 | |
| 580 | Phosphorylation | LKKLRRSSSLKERSR HHHHHCCCCHHHCCC | 37.57 | 22324799 | |
| 581 | Phosphorylation | KKLRRSSSLKERSRP HHHHCCCCHHHCCCC | 44.71 | 30635358 | |
| 590 | Phosphorylation | KERSRPFTVAASFRT HHCCCCCEEEEEEEC | 16.36 | 23140645 | |
| 594 | Phosphorylation | RPFTVAASFRTSSIK CCCEEEEEEECCCCC | 12.91 | 18779572 | |
| 597 | Phosphorylation | TVAASFRTSSIKSPK EEEEEEECCCCCCCC | 25.47 | 24453211 | |
| 598 | Phosphorylation | VAASFRTSSIKSPKA EEEEEECCCCCCCCC | 26.30 | 23140645 | |
| 599 | Phosphorylation | AASFRTSSIKSPKAS EEEEECCCCCCCCCC | 33.16 | 30352176 | |
| 602 | Phosphorylation | FRTSSIKSPKASSPS EECCCCCCCCCCCCC | 29.93 | 26824392 | |
| 604 | Malonylation | TSSIKSPKASSPSLR CCCCCCCCCCCCCHH | 68.91 | 26320211 | |
| 606 | Phosphorylation | SIKSPKASSPSLRKG CCCCCCCCCCCHHCC | 49.24 | 22324799 | |
| 607 | Phosphorylation | IKSPKASSPSLRKGW CCCCCCCCCCHHCCC | 24.30 | 26824392 | |
| 609 | Phosphorylation | SPKASSPSLRKGWSE CCCCCCCCHHCCCCH | 42.63 | 21183079 | |
| 615 | Phosphorylation | PSLRKGWSESEQSEE CCHHCCCCHHHHHHH | 39.66 | 25521595 | |
| 617 | Phosphorylation | LRKGWSESEQSEEFG HHCCCCHHHHHHHHC | 35.11 | 23684622 | |
| 620 | Phosphorylation | GWSESEQSEEFGGGI CCCHHHHHHHHCCCC | 34.73 | 25521595 | |
| 629 | Phosphorylation | EFGGGIATMERKQTE HHCCCCCCCCHHHCC | 20.04 | 25777480 | |
| 641 | Phosphorylation | QTENARPSGEKENVG HCCCCCCCCCCCCCC | 54.77 | 26824392 | |
| 660 | Phosphorylation | QGEEVPRSKDRSSFE CCCCCCCCCCCCCHH | 32.60 | 29514104 | |
| 664 | Phosphorylation | VPRSKDRSSFELESE CCCCCCCCCHHCCCC | 49.89 | 25338131 | |
| 692 | Phosphorylation | NHVHAQQSPLEPEAP CCCCCCCCCCCCCCC | 21.26 | 24453211 | |
| 714 | Phosphorylation | TTAAKEFTTQNQKSQ HHHHHHHCCCCCCCC | 28.67 | 26643407 | |
| 715 | Phosphorylation | TAAKEFTTQNQKSQD HHHHHHCCCCCCCCC | 30.73 | 26643407 | |
| 719 | Ubiquitination | EFTTQNQKSQDVGFW HHCCCCCCCCCCCCC | 58.60 | - | |
| 720 | Phosphorylation | FTTQNQKSQDVGFWE HCCCCCCCCCCCCCC | 23.11 | 25521595 | |
| 735 | Phosphorylation | GEVVRELSVEEQIKR CEEEEEECHHHHHHH | 23.80 | 25521595 | |
| 745 | Phosphorylation | EQIKRNRYYDEDEDE HHHHHCCCCCCCCCC | 20.86 | 22817900 | |
| 746 | Phosphorylation | QIKRNRYYDEDEDEE HHHHCCCCCCCCCCC | 15.04 | 22817900 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LIMA1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LIMA1_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, AND MASSSPECTROMETRY. | |
| "The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735, AND MASSSPECTROMETRY. | |
| "Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225; SER-230; SER-467AND SER-488, AND MASS SPECTROMETRY. | |
| "Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-488, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225; SER-230; SER-367;SER-485; SER-488 AND SER-615, AND MASS SPECTROMETRY. | |
| "Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, AND MASSSPECTROMETRY. | |
