ADX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADX_HUMAN
• UniProt AC: P10109
• Protein Name: Adrenodoxin, mitochondrial
• Gene Name: FDX1
• Organism: Homo sapiens (Human).
• Sequence Length: 184
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Essential for the synthesis of various steroid hormones. [PubMed: 20547883]
• Protein Sequence: MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDVGKTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	ARLLRAASAVLGGPA HHHHHHHHHHHCCCH	20.23	21949786
34	Phosphorylation	HAGSRAGSSGLLRNR HCCCCCCCCCCCCCC	21.90	27251275
35	Phosphorylation	AGSRAGSSGLLRNRG CCCCCCCCCCCCCCC	32.32	27251275
46	Phosphorylation	RNRGPGGSAEASRSL CCCCCCCCCHHHHHC	28.93	101545329
50	Phosphorylation	PGGSAEASRSLSVSA CCCCCHHHHHCEEEE	17.57	27251275
52	Phosphorylation	GSAEASRSLSVSARA CCCHHHHHCEEEEEC	23.62	27251275
54	Phosphorylation	AEASRSLSVSARARS CHHHHHCEEEEECCC	18.44	21406692
56	Phosphorylation	ASRSLSVSARARSSS HHHHCEEEEECCCCC	14.52	21406692
61	Phosphorylation	SVSARARSSSEDKIT EEEEECCCCCCCCEE	36.91	30278072
62	Phosphorylation	VSARARSSSEDKITV EEEECCCCCCCCEEE	31.99	30278072
63	Phosphorylation	SARARSSSEDKITVH EEECCCCCCCCEEEE	51.57	23401153
66	Acetylation	ARSSSEDKITVHFIN CCCCCCCCEEEEEEC	35.90	-
66	Succinylation	ARSSSEDKITVHFIN CCCCCCCCEEEEEEC	35.90	-
66	Succinylation	ARSSSEDKITVHFIN CCCCCCCCEEEEEEC	35.90	-
68	Phosphorylation	SSSEDKITVHFINRD CCCCCCEEEEEECCC	17.42	28302921
131	Phosphorylation	YEKLDAITDEENDML HHHHHHCCCCCCCHH	38.79	42987
149	Methylation	YGLTDRSRLGCQICL HCCCCHHHCCCEEEE	35.67	-
158	Succinylation	GCQICLTKSMDNMTV CCEEEEEECCCCEEE	30.73	-
158	Succinylation	GCQICLTKSMDNMTV CCEEEEEECCCCEEE	30.73	-
159	Phosphorylation	CQICLTKSMDNMTVR CEEEEEECCCCEEEE	26.57	29802988
170	Phosphorylation	MTVRVPETVADARQS EEEECCHHHHHHHHH	18.22	113305607
177	Phosphorylation	TVADARQSIDVGKTS HHHHHHHHCCCCCCC	18.40	24275569
182	Ubiquitination	RQSIDVGKTS----- HHHCCCCCCC-----	45.50	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPB_HUMAN	ATP5B	physical	20547883
ATPA_HUMAN	ATP5A1	physical	20547883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00648: Mitotane