dbPTM

TMOD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMOD3_MOUSE
UniProt AC	Q9JHJ0
Protein Name	Tropomodulin-3
Gene Name	Tmod3
Organism	Mus musculus (Mouse).
Sequence Length	352
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)..
Protein Sequence	MALPFRKDLGDYKDLDEDELLGKLSESELKQLETVLDDLDPENALLPAGFRQKNQTSKSATGPFDRERLLSYLEKQALEHKDRDDYVPYTGEKKGKIFIPKQKPAQTLTEETISLDPELEEALTSASDTELCDLAAILGMHNLIADTPFCDVLGSSNGVNQERFPNVVKGEKILPVFDEPPNPTNVEESLKRIRENDARLVEVNLNNIKNIPIPTLKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELKIDNQRQQLGTSVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNNDLVRKRRIEGDHQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	FRKDLGDYKDLDEDE CCCCCCCCCCCCHHH	12.47	25159016
23	Ubiquitination	DEDELLGKLSESELK CHHHHHHHCCHHHHH	49.13	-
25	Phosphorylation	DELLGKLSESELKQL HHHHHHCCHHHHHHH	42.43	26824392
27	Phosphorylation	LLGKLSESELKQLET HHHHCCHHHHHHHHH	44.87	26745281
71	Phosphorylation	FDRERLLSYLEKQAL CCHHHHHHHHHHHHH	32.06	26824392
72	Phosphorylation	DRERLLSYLEKQALE CHHHHHHHHHHHHHH	20.89	28833060
75	Ubiquitination	RLLSYLEKQALEHKD HHHHHHHHHHHHCCC	37.97	-
86	Phosphorylation	EHKDRDDYVPYTGEK HCCCCCCCCCCCCCC	13.96	25367039
172	Acetylation	PNVVKGEKILPVFDE CCCCCCCEEEECCCC	59.20	23236377
299	Phosphorylation	NQRQQLGTSVELEMA HHHHHHCCHHHHHHH	37.89	28066266
300	Phosphorylation	QRQQLGTSVELEMAK HHHHHCCHHHHHHHH	16.28	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	S	Phosphorylation	Kinase	AKT2	P31751	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMOD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMOD3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTB_HUMAN	ACTB	physical	26496610
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
ADDA_HUMAN	ADD1	physical	26496610
ADDG_HUMAN	ADD3	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CD44_HUMAN	CD44	physical	26496610
CD59_HUMAN	CD59	physical	26496610
CDC42_HUMAN	CDC42	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DDX10_HUMAN	DDX10	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
GNAO_HUMAN	GNAO1	physical	26496610
GBB2_HUMAN	GNB2	physical	26496610
GELS_HUMAN	GSN	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
PALM_HUMAN	PALM	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
RALA_HUMAN	RALA	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
MTEF1_HUMAN	MTERF1	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
LRRF1_HUMAN	LRRFIP1	physical	26496610
LRRF2_HUMAN	LRRFIP2	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ARPC4_HUMAN	ARPC4	physical	26496610
ARPC3_HUMAN	ARPC3	physical	26496610
ARC1B_HUMAN	ARPC1B	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
ARPC2_HUMAN	ARPC2	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
RRAS2_HUMAN	RRAS2	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
COBL_HUMAN	COBL	physical	26496610
FBX46_HUMAN	FBXO46	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
PACN3_HUMAN	PACSIN3	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
DEN1A_HUMAN	DENND1A	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
ARV1_HUMAN	ARV1	physical	26496610
TBL1R_HUMAN	TBL1XR1	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
MYO19_HUMAN	MYO19	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
STON2_HUMAN	STON2	physical	26496610
SSH2_HUMAN	SSH2	physical	26496610
PHLB2_HUMAN	PHLDB2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
UBX2A_HUMAN	UBXN2A	physical	26496610
GA2L3_HUMAN	GAS2L3	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMOD3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line."; Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.; Mol. Cell. Proteomics 3:279-286(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASSSPECTROMETRY.	14729942 [Abstract]