dbPTM

NOXA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOXA1_HUMAN
UniProt AC	Q86UR1
Protein Name	NADPH oxidase activator 1
Gene Name	NOXA1
Organism	Homo sapiens (Human).
Sequence Length	476
Subcellular Localization	Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Protein Description	Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3..
Protein Sequence	MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPRGEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSPRAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPAGAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQGDQP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASLGDLVRA -----CCCHHHHHHH	31.42	25072903
110	Phosphorylation	RGHAAIDYTQLGLRF CCCCCCCHHHHCHHH	7.12	20943948
172	Phosphorylation	DQVQRRGSLPPRQVP HHHHHHCCCCCCCCC	35.57	17913709
202	Ubiquitination	EPVDFLGKAKVVASA CCCCHHCEEEEEEEE	47.37	29967540
234	Phosphorylation	GANHDARSLIMDSPR CCCCCHHHHHHCCCC	24.78	23312004
239	Phosphorylation	ARSLIMDSPRAGTHQ HHHHHHCCCCCCCCC	10.02	21815630
282	Phosphorylation	VGKQAPLSPGLPAMG HHCCCCCCCCCCCCC	18.83	20110267
335	Phosphorylation	ARRGADLSSLRALLG HHCCCCHHHHHHHHH	28.07	30301811
336	Phosphorylation	RRGADLSSLRALLGQ HCCCCHHHHHHHHHH	29.22	25954137
409	Phosphorylation	YQVVAQHSYSAQGPE EEEEECCCCCCCCCH	14.54	24719451
461	Phosphorylation	VPAGPRMSGAPGRLP EECCCCCCCCCCCCC	32.84	17913709
470	Phosphorylation	APGRLPRSQQGDQP- CCCCCCHHHCCCCC-	25.56	24719451
477	Phosphorylation	SQQGDQP-------- HHCCCCC--------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
110	Y	Phosphorylation	Kinase	SRC	P12931	PSP
172	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
172	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
172	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
172	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
172	S	Phosphorylation	Kinase	PKA	-	Uniprot
239	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
282	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
282	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
282	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
282	S	Phosphorylation	Kinase	ERK-SUBFAMILY	-	GPS
282	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
461	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
461	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
461	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOXA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOXA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOX1_HUMAN	NOX1	physical	20110267
RAC1_HUMAN	RAC1	physical	20110267
RIM3A_HUMAN	RIMBP3	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOXA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1and 14-3-3 binding."; Kim J.-S., Diebold B.A., Babior B.M., Knaus U.G., Bokoch G.M.; J. Biol. Chem. 282:34787-34800(2007). Cited for: INTERACTION WITH YWHAZ, MUTAGENESIS OF SER-172 AND SER-461, ANDPHOSPHORYLATION AT SER-172 AND SER-461.	17913709 [Abstract]