NOX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOX1_HUMAN
• UniProt AC: Q9Y5S8
• Protein Name: NADPH oxidase 1
• Gene Name: NOX1
• Organism: Homo sapiens (Human).
• Sequence Length: 564
• Subcellular Localization: Cell projection, invadopodium membrane ; Multi-pass membrane protein . Cell membrane .
• Protein Description: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain..
• Protein Sequence: MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	YTRKILGSTLACARA HHHHHHHHHHHHHHH	19.46	26074081
49	Phosphorylation	TRKILGSTLACARAS HHHHHHHHHHHHHHH	19.31	26074081
56	Phosphorylation	TLACARASALCLNFN HHHHHHHHHHHHCCC	19.07	26074081
64	Phosphorylation	ALCLNFNSTLILLPV HHHHCCCCHHHHHHH	22.06	26074081
65	Phosphorylation	LCLNFNSTLILLPVC HHHCCCCHHHHHHHH	20.94	26074081
82	Phosphorylation	LLSFLRGTCSFCSRT HHHHHHHHCHHHHHH	9.88	-
89	Phosphorylation	TCSFCSRTLRKQLDH HCHHHHHHHHHHCCC	18.02	-
160	Phosphorylation	SWLNPIQSRNTTVEY CCCCCCCCCCCEEEE	28.37	-
162	N-linked_Glycosylation	LNPIQSRNTTVEYVT CCCCCCCCCEEEEEE	45.40	24365146
231	Phosphorylation	GGIVRGQTEESMNES HHHHCCCCHHHCCCC	44.54	-
234	Phosphorylation	VRGQTEESMNESHPR HCCCCHHHCCCCCCC	22.22	-
236	N-linked_Glycosylation	GQTEESMNESHPRKC CCCHHHCCCCCCCHH	57.82	24365146
238	Phosphorylation	TEESMNESHPRKCAE CHHHCCCCCCCHHHH	33.51	-
294	Ubiquitination	RFYRSQQKVVITKVV HHHHHCCCEEEEEEE	30.72	-
298	Phosphorylation	SQQKVVITKVVMHPS HCCCEEEEEEEECHH	13.23	19764811
373	Phosphorylation	IRAFEQQYSPIPRIE HHHHHHHCCCCCEEE	18.99	28442448
374	Phosphorylation	RAFEQQYSPIPRIEV HHHHHHCCCCCEEEE	16.41	28442448
412	Phosphorylation	IGVTPFASILKSIWY CCCCCHHHHHHHHHH	28.91	24719451
453	Phosphorylation	SWFNNLLTSLEQEME HHHHHHHHHHHHHHH	34.14	-
454	Phosphorylation	WFNNLLTSLEQEMEE HHHHHHHHHHHHHHH	29.85	-
470	Phosphorylation	GKVGFLNYRLFLTGW HCCCCCEEEEEECCC	15.73	-
515	Phosphorylation	PMWDNEFSTIATSHP CCCCCCCHHHCCCCC	16.84	22617229
516	Phosphorylation	MWDNEFSTIATSHPK CCCCCCHHHCCCCCC	21.69	22617229
547	Phosphorylation	LRKCCHRYSSLDPRK HHHHHHHHHCCCHHH	4.48	30177828
548	Phosphorylation	RKCCHRYSSLDPRKV HHHHHHHHCCCHHHE	25.12	30177828
549	Phosphorylation	KCCHRYSSLDPRKVQ HHHHHHHCCCHHHEE	28.05	27499020

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P2R3B_HUMAN	PPP2R3B	physical	28514442
RHBL4_HUMAN	RHBDD1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.