FLNB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLNB_MOUSE
• UniProt AC: Q80X90
• Protein Name: Filamin-B
• Gene Name: Flnb
• Organism: Mus musculus (Mouse).
• Sequence Length: 2602
• Subcellular Localization: Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, cytoskeleton. May localize also at actin stress fibers and within the Z-lines..
• Protein Description: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity)..
• Protein Sequence: MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMHHKYHQRPTFRQMKLENVSVALEFLDHESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPRKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNKEEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFAGQHISKSPFEVNVDKAQGDASKVTAKGPGLETTGNIANKPTYFDIYTAGAGVGDIGIEVEDPQGKNSVELLVEDRGNQVYRCVYKPVQPGPHVVKVSFAGDAIPKSPFGVQIGEACNPNACRASGRGLQPKGVRIRETADFKVDTKAAGSGELGVTVKGPKGLEELVKQKGFLDGVYSFEYYPSTPGKYSVAVTWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGDYNPDLVQAYGPGLEKSGCTINNPAEFIVDPKDAGSAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPLKAIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTFTVKYVPPAPGRYTIKVLFASQEIPASPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVHTKGAGKAPLNVQFSSPLPGEAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKINGLENRVEVGKDQEFAIDTNGAGGQGKLDVTILSPSRKVVPCLVAPVAGRECSTAKFIPREEGLFAVDVTYDGHPVPGSPYTVEASLPPDPTKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEPGILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPAWVKVEPAIDTSGIKAFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAQITNPSGASTECFVKDNADGTYQVEYTPFEKGFHVVEVTYDDVPIPNSPFKVAVTEGCQPSRVHAQGPGLKEAFTNKSNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGVHIPGSPFRVPSKDVVDPSKVKIAGPGLSSCVRACIPQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYIVSVKYADEEIPRSPFKVKVLPTYDASKVTASGPGLSAYGVPASLPVEFAIDARDAGEGLLAVQITDQEGKPQRATVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDNIPLSPYRIRATQTGDASKCLATGPGIAPTVKTGEEVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAMEEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGTVHMPSGKKATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYRGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDNRRCSQVKLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGQGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVRESITRTSRAPAVATVGSICDLNLKIPEINSSDMSAHVTSPSGHVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGIPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPDSPYLVPVIAPSDDARCLTVLSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGAGLETGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEIPEGYKVMYTPMAPGNYLIGVKYGGPNHISRSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKSSSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGKQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MPVTEKDLAEDAP --CCCCHHHHHCCCC	48.99	22826441
15	Acetylation	LAEDAPWKKIQQNTF HHCCCCHHHHHHHHH	38.65	23236377
16	Acetylation	AEDAPWKKIQQNTFT HCCCCHHHHHHHHHH	41.71	23806337
16	Succinylation	AEDAPWKKIQQNTFT HCCCCHHHHHHHHHH	41.71	23806337
16	Ubiquitination	AEDAPWKKIQQNTFT HCCCCHHHHHHHHHH	41.71	-
21	Phosphorylation	WKKIQQNTFTRWCNE HHHHHHHHHHHHHHH	23.26	25338131
93	Acetylation	FLDHESIKLVSIDSK CCCCCCEEEEEECCC	52.71	19850009
96	Phosphorylation	HESIKLVSIDSKAIV CCCEEEEEECCCCEE	30.99	25338131
100	Acetylation	KLVSIDSKAIVDGNL EEEEECCCCEECCCH	38.08	23236377
216	Phosphorylation	LGVPQVITPEEIIHP CCCCCCCCHHHCCCC	26.28	-
249	Ubiquitination	LKPGAPLKPKLNPKK CCCCCCCCCCCCHHH	38.76	27667366
251	Ubiquitination	PGAPLKPKLNPKKAR CCCCCCCCCCHHHHH	60.35	27667366
267	Phosphorylation	YGRGIEPTGNMVKQP CCCCCCCCCCCCCCC	28.53	-
306	Phosphorylation	NKEEARVTPDSDKNK CCEEEEECCCCCCCC	18.80	29550500
313	Acetylation	TPDSDKNKTYSVEYL CCCCCCCCEEEEEEC	55.36	23806337
341	Phosphorylation	AGQHISKSPFEVNVD CCCCCCCCCCEECCC	28.20	26824392
349	Acetylation	PFEVNVDKAQGDASK CCEECCCHHCCCHHH	38.02	23806337
349	Succinylation	PFEVNVDKAQGDASK CCEECCCHHCCCHHH	38.02	23806337
440	Phosphorylation	AGDAIPKSPFGVQIG CCCCCCCCCCCCEEC	21.80	26370283
490	Phosphorylation	GSGELGVTVKGPKGL CCCCCEEEEECCCCH	18.07	24759943
492	Ubiquitination	GELGVTVKGPKGLEE CCCEEEEECCCCHHH	61.19	22790023
495	Ubiquitination	GVTVKGPKGLEELVK EEEEECCCCHHHHHH	82.10	22790023
502	Acetylation	KGLEELVKQKGFLDG CCHHHHHHHCCCCCC	59.94	23806337
502	Succinylation	KGLEELVKQKGFLDG CCHHHHHHHCCCCCC	59.94	23806337
502	Ubiquitination	KGLEELVKQKGFLDG CCHHHHHHHCCCCCC	59.94	-
511	Phosphorylation	KGFLDGVYSFEYYPS CCCCCCEEEEEEECC	17.11	22817900
516	Phosphorylation	GVYSFEYYPSTPGKY CEEEEEEECCCCCEE	5.41	26643407
518	Phosphorylation	YSFEYYPSTPGKYSV EEEEEECCCCCEEEE	30.98	26745281
519	Phosphorylation	SFEYYPSTPGKYSVA EEEEECCCCCEEEEE	31.40	27180971
551	Acetylation	GPEAGMQKVRAWGPG CCHHCHHHHHCCCCC	25.46	23806337
551	Succinylation	GPEAGMQKVRAWGPG CCHHCHHHHHCCCCC	25.46	23806337
603	Phosphorylation	YDDQNDGSCDVKYWP ECCCCCCCCEEEEEC	15.26	26824392
604	S-nitrosocysteine	DDQNDGSCDVKYWPK CCCCCCCCEEEEECC	9.48	-
604	S-nitrosylation	DDQNDGSCDVKYWPK CCCCCCCCEEEEECC	9.48	20925432
607	Acetylation	NDGSCDVKYWPKEPG CCCCCEEEEECCCCC	28.48	22826441
658	Phosphorylation	YGPGLEKSGCTINNP HCCCCCCCCCCCCCC	29.71	22817900
661	Phosphorylation	GLEKSGCTINNPAEF CCCCCCCCCCCCCEE	30.20	23984901
681	Acetylation	DAGSAPLKILAQDGE HCCCCCEEEEEECCC	34.32	23236377
697	Ubiquitination	QPIDIQMKSRMDGTY CEEEEEEEECCCCEE	20.66	22790023
698	Phosphorylation	PIDIQMKSRMDGTYA EEEEEEEECCCCEEE	27.74	25367039
703	Phosphorylation	MKSRMDGTYACSYTP EEECCCCEEECCCCC	12.04	25367039
704	Phosphorylation	KSRMDGTYACSYTPL EECCCCEEECCCCCH	15.90	22817900
706	S-palmitoylation	RMDGTYACSYTPLKA CCCCEEECCCCCHHH	1.94	28526873
709	Phosphorylation	GTYACSYTPLKAIKH CEEECCCCCHHHHCC	13.07	-
730	Phosphorylation	GGVNIPHSPYRVNIG CCCCCCCCCCEEECC	20.48	-
755	Phosphorylation	FGPGVERSGLKANEP ECCCCCCCCCCCCCC	34.66	26824392
789	Phosphorylation	KCDARVLSDDEEDVD EEEEEECCCCCCCCC	39.91	27087446
827	Phosphorylation	TIKVLFASQEIPASP EEEEEEECCCCCCCC	22.47	26824392
833	Phosphorylation	ASQEIPASPFRVKVD ECCCCCCCCCEEEEC	21.15	26824392
838	Acetylation	PASPFRVKVDPSHDA CCCCCEEEECCCCCH	36.34	23806337
849	Acetylation	SHDASKVKAEGPGLS CCCHHHCCCCCCCCC	44.44	23806337
849	Malonylation	SHDASKVKAEGPGLS CCCHHHCCCCCCCCC	44.44	26320211
849	Succinylation	SHDASKVKAEGPGLS CCCHHHCCCCCCCCC	44.44	23806337
885	Phosphorylation	APLNVQFSSPLPGEA CCEEEEECCCCCCCC	17.60	30352176
886	Phosphorylation	PLNVQFSSPLPGEAV CEEEEECCCCCCCCC	31.57	29233185
902	Phosphorylation	DLDIIDNYDYSHTVK CCEEECCCCCCCEEE	16.71	23984901
904	Phosphorylation	DIIDNYDYSHTVKYT EEECCCCCCCEEEEC	7.62	26026062
905	Phosphorylation	IIDNYDYSHTVKYTP EECCCCCCCEEEECC	15.13	23984901
907	Phosphorylation	DNYDYSHTVKYTPTQ CCCCCCCEEEECCCC	16.86	23984901
932	Phosphorylation	GGDPIPKSPFTVGVA CCCCCCCCCCEEEEE	21.64	26824392
935	Phosphorylation	PIPKSPFTVGVAAPL CCCCCCCEEEEECCC	21.53	26643407
946	Acetylation	AAPLDLSKIKINGLE ECCCCHHHCEECCEE	56.14	23236377
980	Phosphorylation	GQGKLDVTILSPSRK CCCEEEEEEECCCCC	18.83	29550500
983	Phosphorylation	KLDVTILSPSRKVVP EEEEEEECCCCCEEE	19.58	26824392
985	Phosphorylation	DVTILSPSRKVVPCL EEEEECCCCCEEEEE	41.16	22942356
987	Acetylation	TILSPSRKVVPCLVA EEECCCCCEEEEEEE	52.50	22826441
987	Malonylation	TILSPSRKVVPCLVA EEECCCCCEEEEEEE	52.50	26320211
991	S-nitrosocysteine	PSRKVVPCLVAPVAG CCCCEEEEEEECCCC	3.01	-
991	S-nitrosylation	PSRKVVPCLVAPVAG CCCCEEEEEEECCCC	3.01	20925432
991	S-palmitoylation	PSRKVVPCLVAPVAG CCCCEEEEEEECCCC	3.01	28526873
1028	Phosphorylation	DGHPVPGSPYTVEAS CCEECCCCCEEEEEE	14.52	-
1081	Glutathionylation	GLTVEGPCEAKIECS CCEEECCCEEEEEEC	13.44	24333276
1172	Phosphorylation	TLGLEAVSDSGAKAE EEEEEEECCCCCEEE	32.86	26824392
1194	Phosphorylation	DGTYAVTYVPLTAGM CCCEEEEEEEECCEE	8.09	28576409
1232	Acetylation	AIDTSGIKAFGPGIE CCCCCCCCCCCCCCC	40.98	23806337
1232	Succinylation	AIDTSGIKAFGPGIE CCCCCCCCCCCCCCC	40.98	23806337
1241	Acetylation	FGPGIEGKDVFREAT CCCCCCCCHHHHHCC	37.62	23806337
1241	Succinylation	FGPGIEGKDVFREAT CCCCCCCCHHHHHCC	37.62	23806337
1241	Ubiquitination	FGPGIEGKDVFREAT CCCCCCCCHHHHHCC	37.62	-
1277	Phosphorylation	ITNPSGASTECFVKD EECCCCCCEEEEEEE	28.41	26824392
1280	S-nitrosocysteine	PSGASTECFVKDNAD CCCCCEEEEEEECCC	4.87	-
1280	S-nitrosylation	PSGASTECFVKDNAD CCCCCEEEEEEECCC	4.87	20925432
1280	S-palmitoylation	PSGASTECFVKDNAD CCCCCEEEEEEECCC	4.87	28526873
1307	Phosphorylation	GFHVVEVTYDDVPIP CEEEEEEEECCCCCC	14.02	-
1316	Phosphorylation	DDVPIPNSPFKVAVT CCCCCCCCCCEEEEE	26.76	26824392
1326	Glutathionylation	KVAVTEGCQPSRVHA EEEEECCCCCCCEEC	4.35	24333276
1339	Ubiquitination	HAQGPGLKEAFTNKS ECCCCCHHHHHCCCC	53.57	22790023
1345	Acetylation	LKEAFTNKSNVFTVV HHHHHCCCCCEEEEE	40.11	23806337
1364	Phosphorylation	GIGGLGITVEGPSES CCCCCEEEEECCCCC	15.65	29514104
1395	Phosphorylation	IPFAPGDYDVNITYG ECCCCCCCEEEEEEC	27.92	-
1409	Phosphorylation	GGVHIPGSPFRVPSK CCEECCCCCCCCCCC	18.60	23608596
1416	Acetylation	SPFRVPSKDVVDPSK CCCCCCCCCCCCHHH	48.77	23806337
1416	Succinylation	SPFRVPSKDVVDPSK CCCCCCCCCCCCHHH	48.77	23806337
1425	Malonylation	VVDPSKVKIAGPGLS CCCHHHCEECCCCHH	30.49	26320211
1433	Phosphorylation	IAGPGLSSCVRACIP ECCCCHHHHHHHHCC	22.98	26824392
1434	S-nitrosocysteine	AGPGLSSCVRACIPQ CCCCHHHHHHHHCCC	1.84	-
1434	Glutathionylation	AGPGLSSCVRACIPQ CCCCHHHHHHHHCCC	1.84	24333276
1434	S-nitrosylation	AGPGLSSCVRACIPQ CCCCHHHHHHHHCCC	1.84	20925432
1434	S-palmitoylation	AGPGLSSCVRACIPQ CCCCHHHHHHHHCCC	1.84	28526873
1505	Phosphorylation	ADEEIPRSPFKVKVL CCCCCCCCCCEEEEE	29.36	26824392
1508	Ubiquitination	EIPRSPFKVKVLPTY CCCCCCCEEEEECCC	44.52	22790023
1510	Acetylation	PRSPFKVKVLPTYDA CCCCCEEEEECCCCC	38.35	23806337
1510	Malonylation	PRSPFKVKVLPTYDA CCCCCEEEEECCCCC	38.35	26320211
1510	Succinylation	PRSPFKVKVLPTYDA CCCCCEEEEECCCCC	38.35	23806337
1557	Phosphorylation	GLLAVQITDQEGKPQ CEEEEEEECCCCCCE	17.97	22817900
1572	Acetylation	RATVHDNKDGTYAVT EEEEEECCCCEEEEE	64.69	23806337
1572	Succinylation	RATVHDNKDGTYAVT EEEEEECCCCEEEEE	64.69	23806337
1572	Ubiquitination	RATVHDNKDGTYAVT EEEEEECCCCEEEEE	64.69	-
1585	Phosphorylation	VTYIPDKTGRYMIGV EEEECCCCCCEEEEE	33.98	28576409
1602	Phosphorylation	GGDNIPLSPYRIRAT CCCCCCCCCEEEEEE	17.96	26824392
1609	Phosphorylation	SPYRIRATQTGDASK CCEEEEEEECCCHHH	19.47	26824392
1641	Ubiquitination	VGFVVDAKTAGKGKV EEEEEEEECCCCCEE	34.15	22790023
1687	Phosphorylation	KPGTYVIYVRFGGVD CCCEEEEEEEECCEE	3.89	26824392
1756	Ubiquitination	LVIPFAVRKGEITGT EEEEEEEECCEEEEE	37.52	27667366
1761	Phosphorylation	AVRKGEITGTVHMPS EEECCEEEEEEECCC	23.62	20469934
1763	Phosphorylation	RKGEITGTVHMPSGK ECCEEEEEEECCCCC	9.89	20469934
1769	Ubiquitination	GTVHMPSGKKATPEI EEEECCCCCCCCCCE	29.61	27667366
1771	Malonylation	VHMPSGKKATPEIVD EECCCCCCCCCCEEC	62.10	26320211
1780	Acetylation	TPEIVDNKDGTVTVR CCCEECCCCCEEEEE	53.74	23806337
1780	Ubiquitination	TPEIVDNKDGTVTVR CCCEECCCCCEEEEE	53.74	22790023
1801	Acetylation	GLHEMHIKYRGSHIP EEEEEEEEECCCCCC	17.76	23806337
1810	Phosphorylation	RGSHIPESPLQFYVN CCCCCCCCCCEEEEE	26.09	26824392
1868	S-nitrosocysteine	PSKAEISCIDNKDGT CCCEEEEEEECCCCE	5.79	-
1868	S-nitrosylation	PSKAEISCIDNKDGT CCCEEEEEEECCCCE	5.79	20925432
1897	Ubiquitination	ILVKYNDKHIPGSPF EEEEECCCCCCCCCC	39.53	22790023
1902	Phosphorylation	NDKHIPGSPFTAKIT CCCCCCCCCCEEEEC	16.10	26824392
1916	Phosphorylation	TDDNRRCSQVKLGSA CCCCCEECCEECCHH	35.88	22324799
1922	Phosphorylation	CSQVKLGSAADFLLD ECCEECCHHHHHHHC	30.62	26824392
1982	Ubiquitination	LVSIKKNGNHVANSP EEEEEECCCCCCCCC	34.20	27667366
1988	Phosphorylation	NGNHVANSPVSIMVV CCCCCCCCCEEEEEE	19.55	29514104
1995	Ubiquitination	SPVSIMVVQSEIGDA CCEEEEEEECCCCCH	2.61	27667366
2006	Ubiquitination	IGDARRAKVYGQGLS CCCHHHHEEECCCCC	33.89	27667366
2008	Phosphorylation	DARRAKVYGQGLSEG CHHHHEEECCCCCCC	11.74	29895711
2013	Phosphorylation	KVYGQGLSEGRTFEM EEECCCCCCCCCEEC	44.84	-
2057	S-nitrosocysteine	EDLEDGTCKVSYFPT CCCCCCEEEEEEECC	5.11	-
2057	S-nitrosylation	EDLEDGTCKVSYFPT CCCCCCEEEEEEECC	5.11	20925432
2083	Phosphorylation	ADEHVPGSPFTVKIS CCCCCCCCCEEEEEC	15.69	24899341
2086	Phosphorylation	HVPGSPFTVKISGEG CCCCCCEEEEECCCC	25.03	26824392
2088	Acetylation	PGSPFTVKISGEGRV CCCCEEEEECCCCCE	28.26	23236377
2088	Ubiquitination	PGSPFTVKISGEGRV CCCCEEEEECCCCCE	28.26	22790023
2098	Phosphorylation	GEGRVRESITRTSRA CCCCEEEEEECCCCC	20.78	29895711
2100	Phosphorylation	GRVRESITRTSRAPA CCEEEEEECCCCCCC	36.85	22817900
2102	Phosphorylation	VRESITRTSRAPAVA EEEEEECCCCCCCEE	17.57	19854140
2113	Phosphorylation	PAVATVGSICDLNLK CCEEEHHHHHEEECC	18.73	22324799
2115	S-nitrosocysteine	VATVGSICDLNLKIP EEEHHHHHEEECCCC	5.36	-
2115	Glutathionylation	VATVGSICDLNLKIP EEEHHHHHEEECCCC	5.36	24333276
2115	S-nitrosylation	VATVGSICDLNLKIP EEEHHHHHEEECCCC	5.36	20925432
2115	S-palmitoylation	VATVGSICDLNLKIP EEEHHHHHEEECCCC	5.36	28526873
2126	Phosphorylation	LKIPEINSSDMSAHV CCCCCCCCCCCCEEE	33.12	23984901
2127	Phosphorylation	KIPEINSSDMSAHVT CCCCCCCCCCCEEEE	32.61	23984901
2130	Phosphorylation	EINSSDMSAHVTSPS CCCCCCCCEEEECCC	21.88	23984901
2134	Phosphorylation	SDMSAHVTSPSGHVT CCCCEEEECCCCCCE	25.67	26160508
2135	Phosphorylation	DMSAHVTSPSGHVTE CCCEEEECCCCCCEE	18.91	26824392
2137	Phosphorylation	SAHVTSPSGHVTEAE CEEEECCCCCCEEEE	41.10	26160508
2141	Phosphorylation	TSPSGHVTEAEIVPM ECCCCCCEEEEEEEC	24.65	23984901
2170	Acetylation	GVHTVSVKYRGQHVT CEEEEEEEECCEECC	23.02	23806337
2170	Malonylation	GVHTVSVKYRGQHVT CEEEEEEEECCEECC	23.02	26320211
2177	Phosphorylation	KYRGQHVTGSPFQFT EECCEECCCCCEEEE	29.80	23608596
2179	Phosphorylation	RGQHVTGSPFQFTVG CCEECCCCCEEEEEE	17.11	26824392
2239	Phosphorylation	GPSKAEITFDDHKNG CCCCEEEEECCCCCC	16.71	22871156
2274	Phosphorylation	NDEHIPDSPYLVPVI CCCCCCCCCCEEEEE	15.30	26824392
2289	S-nitrosocysteine	APSDDARCLTVLSLQ CCCCCHHEEEEEEHH	3.91	-
2289	S-nitrosylation	APSDDARCLTVLSLQ CCCCCHHEEEEEEHH	3.91	20925432
2325	Phosphorylation	KIDAKVHSPSGAVEE EEEEEEECCCCCCEE	24.61	28418008
2327	Phosphorylation	DAKVHSPSGAVEECH EEEEECCCCCCEEEE	42.26	23984901
2336	Phosphorylation	AVEECHVSELEPDKY CCEEEECHHCCCCCE	16.88	26824392
2342	Acetylation	VSELEPDKYAVRFIP CHHCCCCCEEEEEEE	45.91	23806337
2369	Phosphorylation	NGSHVVGSPFKVRVG CCEEECCCCEEEECC	18.63	23608596
2456	Phosphorylation	NYLIGVKYGGPNHIS CEEEEEEECCCCCCC	25.55	22817900
2463	Phosphorylation	YGGPNHISRSPFKAK ECCCCCCCCCCCCCE	21.10	25263469
2465	Phosphorylation	GPNHISRSPFKAKVT CCCCCCCCCCCCEEE	28.09	26824392
2472	Phosphorylation	SPFKAKVTGQRLVSP CCCCCEEECCEEECC	27.22	23984901
2478	Phosphorylation	VTGQRLVSPGSANET EECCEEECCCCCCCC	28.30	27087446
2481	Phosphorylation	QRLVSPGSANETSSI CEEECCCCCCCCCEE	31.16	26824392
2485	Phosphorylation	SPGSANETSSILVES CCCCCCCCCEEEEEE	27.81	25619855
2486	Phosphorylation	PGSANETSSILVESV CCCCCCCCEEEEEEE	14.81	25619855
2487	Phosphorylation	GSANETSSILVESVT CCCCCCCEEEEEEEE	27.62	25619855
2492	Phosphorylation	TSSILVESVTRSSTE CCEEEEEEEECCCCC	22.70	25619855
2494	Phosphorylation	SILVESVTRSSTETC EEEEEEEECCCCCHH	33.83	25619855
2497	Phosphorylation	VESVTRSSTETCYSA EEEEECCCCCHHHHC	27.29	22499769
2500	Ubiquitination	VTRSSTETCYSAIPK EECCCCCHHHHCCCC	19.48	27667366
2502	Phosphorylation	RSSTETCYSAIPKSS CCCCCHHHHCCCCCC	14.46	20116462
2503	Phosphorylation	SSTETCYSAIPKSSS CCCCHHHHCCCCCCC	23.13	22499769
2508	Phosphorylation	CYSAIPKSSSDASKV HHHCCCCCCCCHHHC	29.71	27149854
2509	Phosphorylation	YSAIPKSSSDASKVT HHCCCCCCCCHHHCC	38.06	27149854
2510	Phosphorylation	SAIPKSSSDASKVTS HCCCCCCCCHHHCCC	44.26	27149854
2513	Phosphorylation	PKSSSDASKVTSKGA CCCCCCHHHCCCCCC	32.42	27149854
2513	Ubiquitination	PKSSSDASKVTSKGA CCCCCCHHHCCCCCC	32.42	27667366
2516	Phosphorylation	SSDASKVTSKGAGLS CCCHHHCCCCCCCCC	28.58	27149854
2517	Phosphorylation	SDASKVTSKGAGLSK CCHHHCCCCCCCCCH	31.89	27149854
2518	Acetylation	DASKVTSKGAGLSKA CHHHCCCCCCCCCHH	43.33	23806337
2518	Malonylation	DASKVTSKGAGLSKA CHHHCCCCCCCCCHH	43.33	26320211
2518	Succinylation	DASKVTSKGAGLSKA CHHHCCCCCCCCCHH	43.33	-
2518	Succinylation	DASKVTSKGAGLSKA CHHHCCCCCCCCCHH	43.33	23806337
2524	Acetylation	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	23806337
2524	Succinylation	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	-
2524	Succinylation	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	23806337
2524	Ubiquitination	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	27667366
2530	Acetylation	SKAFVGQKSSFLVDC CHHHCCCCCEEEEEC	41.98	23806337
2532	Phosphorylation	AFVGQKSSFLVDCSK HHCCCCCEEEEECHH	29.63	-
2537	S-palmitoylation	KSSFLVDCSKAGSNM CCEEEEECHHCCCCE	3.33	28526873
2553	Phosphorylation	LIGVHGPTTPCEEVS EEEEECCCCCCHHCC	48.22	26745281
2554	Phosphorylation	IGVHGPTTPCEEVSM EEEECCCCCCHHCCH	29.13	26745281
2560	Phosphorylation	TTPCEEVSMKHVGKQ CCCCHHCCHHCCCCE	25.95	23984901
2566	Acetylation	VSMKHVGKQQYNVTY CCHHCCCCEEEEEEE	32.89	23236377
2566	Ubiquitination	VSMKHVGKQQYNVTY CCHHCCCCEEEEEEE	32.89	22790023
2576	Acetylation	YNVTYVVKERGDYVL EEEEEEEEECCCEEE	31.48	23236377
2581	Phosphorylation	VVKERGDYVLAVKWG EEEECCCEEEEEEEC	10.53	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FLNB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLNB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLNB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
ANXA2_HUMAN	ANXA2	physical	26496610
RHOA_HUMAN	RHOA	physical	26496610
RHOB_HUMAN	RHOB	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CD44_HUMAN	CD44	physical	26496610
CD59_HUMAN	CD59	physical	26496610
COF2_HUMAN	CFL2	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DAPK3_HUMAN	DAPK3	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DSC2_HUMAN	DSC2	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
SRC8_HUMAN	CTTN	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
FYN_HUMAN	FYN	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
RASK_HUMAN	KRAS	physical	26496610
LEG1_HUMAN	LGALS1	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
LYN_HUMAN	LYN	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
PALM_HUMAN	PALM	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
PP1G_HUMAN	PPP1CC	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
RAB1A_HUMAN	RAB1A	physical	26496610
RAB5C_HUMAN	RAB5C	physical	26496610
RAC1_HUMAN	RAC1	physical	26496610
RALA_HUMAN	RALA	physical	26496610
RALB_HUMAN	RALB	physical	26496610
RAP1A_HUMAN	RAP1A	physical	26496610
RAP1B_HUMAN	RAP1B	physical	26496610
RL22_HUMAN	RPL22	physical	26496610
RRAS_HUMAN	RRAS	physical	26496610
SNTB2_HUMAN	SNTB2	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
YES_HUMAN	YES1	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
RAB7A_HUMAN	RAB7A	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
LIPB1_HUMAN	PPFIBP1	physical	26496610
NUMB_HUMAN	NUMB	physical	26496610
SNP23_HUMAN	SNAP23	physical	26496610
ARPC5_HUMAN	ARPC5	physical	26496610
G3BP1_HUMAN	G3BP1	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
RRAS2_HUMAN	RRAS2	physical	26496610
COBL_HUMAN	COBL	physical	26496610
ZDHC5_HUMAN	ZDHHC5	physical	26496610
DECR2_HUMAN	DECR2	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
PACN3_HUMAN	PACSIN3	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
RAB14_HUMAN	RAB14	physical	26496610
LIN7C_HUMAN	LIN7C	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
RAP2C_HUMAN	RAP2C	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
TM237_HUMAN	TMEM237	physical	26496610
AHNK_HUMAN	AHNAK	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
SPRY3_HUMAN	SPRYD3	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
FCHO2_HUMAN	FCHO2	physical	26496610
MISP_HUMAN	MISP	physical	26496610
CD109_HUMAN	CD109	physical	26496610
PPR18_HUMAN	PPP1R18	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1557, AND MASSSPECTROMETRY.
PubMed: 19367708