TM237_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM237_HUMAN
• UniProt AC: Q96Q45
• Protein Name: Transmembrane protein 237
• Gene Name: TMEM237
• Organism: Homo sapiens (Human).
• Sequence Length: 408
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell projection, cilium . Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L.
• Protein Description: Component of the transition zone in primary cilia. Required for ciliogenesis..
• Protein Sequence: MRTDSGARLEEGHLRPPRALPPVPSQDDIPLSRPKKKKPRTKNTPASASLEGLAQTAGRRPSEGNEPSTKELKEHPEAPVQRRQKKTRLPLELETSSTQKKSSSSSLLRNENGIDAEPAEEAVIQKPRRKTKKTQPAELQYANELGVEDEDIITDEQTTVEQQSVFTAPTGISQPVGKVFVEKSRRFQAADRSELIKTTENIDVSMDVKPSWTTRDVALTVHRAFRMIGLFSHGFLAGCAVWNIVVIYVLAGDQLSNLSNLLQQYKTLAYPFQSLLYLLLALSTISAFDRIDFAKISVAIRNFLALDPTALASFLYFTALILSLSQQMTSDRIHLYTPSSVNGSLWEAGIEEQILQPWIVVNLVVALLVGLSWLFLSYRPGMDLSEELMFSSEVEEYPDKEKEIKASS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MRTDSGARLE -----CCCCCCCCCC	32.97	24043423
5	Phosphorylation	---MRTDSGARLEEG ---CCCCCCCCCCCC	33.47	24043423
25	Phosphorylation	RALPPVPSQDDIPLS CCCCCCCCCCCCCCC	46.61	25159151
32	Phosphorylation	SQDDIPLSRPKKKKP CCCCCCCCCCCCCCC	40.98	26074081
41	Phosphorylation	PKKKKPRTKNTPASA CCCCCCCCCCCCCCH	36.85	22287803
42	Ubiquitination	KKKKPRTKNTPASAS CCCCCCCCCCCCCHH	61.17	-
44	Phosphorylation	KKPRTKNTPASASLE CCCCCCCCCCCHHHH	23.07	30266825
47	Phosphorylation	RTKNTPASASLEGLA CCCCCCCCHHHHHHH	21.42	30266825
49	Phosphorylation	KNTPASASLEGLAQT CCCCCCHHHHHHHHH	25.18	30266825
56	Phosphorylation	SLEGLAQTAGRRPSE HHHHHHHHCCCCCCC	26.02	29255136
62	Phosphorylation	QTAGRRPSEGNEPST HHCCCCCCCCCCCCH	57.22	29255136
62	Ubiquitination	QTAGRRPSEGNEPST HHCCCCCCCCCCCCH	57.22	24816145
65	Ubiquitination	GRRPSEGNEPSTKEL CCCCCCCCCCCHHHH	54.69	33845483
68	Phosphorylation	PSEGNEPSTKELKEH CCCCCCCCHHHHHHC	46.03	23927012
69	Phosphorylation	SEGNEPSTKELKEHP CCCCCCCHHHHHHCC	38.97	23927012
70	Ubiquitination	EGNEPSTKELKEHPE CCCCCCHHHHHHCCC	66.44	24816145
73	Ubiquitination	EPSTKELKEHPEAPV CCCHHHHHHCCCCCC	55.88	33845483
92 (in isoform 2)	Ubiquitination	-	42.49	-
92	Ubiquitination	KKTRLPLELETSSTQ HCCCCCCEECCCCCC	42.49	23503661
93	Ubiquitination	KTRLPLELETSSTQK CCCCCCEECCCCCCC	13.17	23503661
95	Phosphorylation	RLPLELETSSTQKKS CCCCEECCCCCCCCC	40.37	21815630
96	Phosphorylation	LPLELETSSTQKKSS CCCEECCCCCCCCCC	23.24	25850435
97	Phosphorylation	PLELETSSTQKKSSS CCEECCCCCCCCCCH	42.13	21815630
98	Phosphorylation	LELETSSTQKKSSSS CEECCCCCCCCCCHH	44.14	25850435
100	Ubiquitination	LETSSTQKKSSSSSL ECCCCCCCCCCHHHH	55.50	23503661
101	Ubiquitination	ETSSTQKKSSSSSLL CCCCCCCCCCHHHHH	45.83	23503661
102	Phosphorylation	TSSTQKKSSSSSLLR CCCCCCCCCHHHHHC	42.35	50564899
103	Phosphorylation	SSTQKKSSSSSLLRN CCCCCCCCHHHHHCC	43.02	25159151
104	Phosphorylation	STQKKSSSSSLLRNE CCCCCCCHHHHHCCC	30.91	25159151
105	Phosphorylation	TQKKSSSSSLLRNEN CCCCCCHHHHHCCCC	27.27	50564903
106	Phosphorylation	QKKSSSSSLLRNENG CCCCCHHHHHCCCCC	33.11	21955146
118	Ubiquitination	ENGIDAEPAEEAVIQ CCCCCCCHHHHHHHC	46.85	23503661
118 (in isoform 2)	Ubiquitination	-	46.85	21906983
122	Ubiquitination	DAEPAEEAVIQKPRR CCCHHHHHHHCCCCC	8.67	23503661
124	Ubiquitination	EPAEEAVIQKPRRKT CHHHHHHHCCCCCCC	5.85	23503661
126	Ubiquitination	AEEAVIQKPRRKTKK HHHHHHCCCCCCCCC	29.39	21906983
130	Ubiquitination	VIQKPRRKTKKTQPA HHCCCCCCCCCCCCH	67.01	23503661
131	Phosphorylation	IQKPRRKTKKTQPAE HCCCCCCCCCCCCHH	35.64	159291
132	Ubiquitination	QKPRRKTKKTQPAEL CCCCCCCCCCCCHHH	57.78	23503661
150 (in isoform 1)	Ubiquitination	-	37.29	21906983
175	Ubiquitination	APTGISQPVGKVFVE CCCCCCCCCCEEHHH	30.00	29967540
183	Ubiquitination	VGKVFVEKSRRFQAA CCEEHHHHHHHHCCC	43.92	29967540
193	Phosphorylation	RFQAADRSELIKTTE HHCCCCHHHHHHHCC	36.98	28857561
201	Ubiquitination	ELIKTTENIDVSMDV HHHHHCCCCCCCCCC	33.40	21963094
201 (in isoform 2)	Ubiquitination	-	33.40	21906983
207 (in isoform 3)	Ubiquitination	-	37.47	-
209	Ubiquitination	IDVSMDVKPSWTTRD CCCCCCCCCCCCHHH	29.12	21963094
233 (in isoform 3)	Ubiquitination	-	24.56	-
233 (in isoform 1)	Ubiquitination	-	24.56	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM237_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM237_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM237_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FIBB_HUMAN	FGB	physical	26186194
PIGR_HUMAN	PIGR	physical	26186194
BPIB1_HUMAN	BPIFB1	physical	26186194
TRFL_HUMAN	LTF	physical	26186194
BPIA1_HUMAN	BPIFA1	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
PERE_HUMAN	EPX	physical	26186194
IGJ_HUMAN	IGJ	physical	26186194
BAP31_HUMAN	BCAP31	physical	26638075
CCD47_HUMAN	CCDC47	physical	26638075
CKAP4_HUMAN	CKAP4	physical	26638075
EMC1_HUMAN	EMC1	physical	26638075
KTN1_HUMAN	KTN1	physical	26638075
LYRIC_HUMAN	MTDH	physical	26638075
SRPRA_HUMAN	SRPR	physical	26638075
EMC2_HUMAN	EMC2	physical	26638075
AL3A2_HUMAN	ALDH3A2	physical	26638075
CDKAL_HUMAN	CDKAL1	physical	26638075
COPA_HUMAN	COPA	physical	26638075
COPB2_HUMAN	COPB2	physical	26638075
EMC8_HUMAN	EMC8	physical	26638075
ECH1_HUMAN	ECH1	physical	26638075
EMD_HUMAN	EMD	physical	26638075
LRC59_HUMAN	LRRC59	physical	26638075
MMGT1_HUMAN	MMGT1	physical	26638075
MTPN_HUMAN	MTPN	physical	26638075
RAE1L_HUMAN	RAE1	physical	26638075
SRP72_HUMAN	SRP72	physical	26638075
SRP09_HUMAN	SRP9	physical	26638075
EMC3_HUMAN	EMC3	physical	26638075
MACOI_HUMAN	TMEM57	physical	26638075
EMC6_HUMAN	EMC6	physical	26638075
TOIP1_HUMAN	TOR1AIP1	physical	26638075
WDR81_HUMAN	WDR81	physical	26638075
PERE_HUMAN	EPX	physical	28514442
BPIA1_HUMAN	BPIFA1	physical	28514442
BPIB1_HUMAN	BPIFB1	physical	28514442
IGJ_HUMAN	IGJ	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
FIBB_HUMAN	FGB	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
TRFL_HUMAN	LTF	physical	28514442
CKLF6_HUMAN	CMTM6	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614424: Joubert syndrome 14 (JBTS14)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.