CKLF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CKLF6_HUMAN
• UniProt AC: Q9NX76
• Protein Name: CKLF-like MARVEL transmembrane domain-containing protein 6 {ECO:0000303|PubMed:28813417}
• Gene Name: CMTM6 {ECO:0000303|PubMed:28813417, ECO:0000312|HGNC:HGNC:19177}
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes.
• Protein Description: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy..
• Protein Sequence: MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRVLKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRAEALTEPLNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MENGAVYS -------CCCCCCCC	9.00	20068231
7	Phosphorylation	-MENGAVYSPTTEED -CCCCCCCCCCCCCC	14.38	25106551
8	Phosphorylation	MENGAVYSPTTEEDP CCCCCCCCCCCCCCC	14.79	28348404
10	Phosphorylation	NGAVYSPTTEEDPGP CCCCCCCCCCCCCCC	40.68	28450419
11	Phosphorylation	GAVYSPTTEEDPGPA CCCCCCCCCCCCCCC	40.54	28450419
23	Phosphorylation	GPARGPRSGLAAYFF CCCCCCCCHHHHHHH	41.09	22210691
28	Phosphorylation	PRSGLAAYFFMGRLP CCCHHHHHHHHCCHH	7.55	22210691
167	Ubiquitination	RQESQLRKPENTTRA HHHHHHCCCCCCCHH	66.33	22053931
171	Phosphorylation	QLRKPENTTRAEALT HHCCCCCCCHHHHHC	18.92	26434776
178	Phosphorylation	TTRAEALTEPLNA-- CCHHHHHCCCCCC--	42.47	29970186

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CKLF6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CKLF6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CKLF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DUS10_HUMAN	DUSP10	physical	21900206
XRCC6_HUMAN	XRCC6	physical	21900206
SUMO2_HUMAN	SUMO2	physical	21900206
AT132_HUMAN	ATP13A2	physical	21900206
DNM3B_HUMAN	DNMT3B	physical	21900206
CXCL7_HUMAN	PPBP	physical	21900206
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330