dbPTM

DUS10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DUS10_HUMAN
UniProt AC	Q9Y6W6
Protein Name	Dual specificity protein phosphatase 10
Gene Name	DUSP10
Organism	Homo sapiens (Human).
Sequence Length	482
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38..
Protein Sequence	MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPPSPLDDRVV ----CCCCCCCCCEE	32.02	16565220
15	Phosphorylation	DRVVVALSRPVRPQD CCEEEEECCCCCHHH	25.46	29514088
224	Phosphorylation	SCREGKDSFKRIFSK HCCCCCHHHHHHHCC	35.83	-
230	Phosphorylation	DSFKRIFSKEIIVYD HHHHHHHCCEEEEEE	27.32	24719451
236	Phosphorylation	FSKEIIVYDENTNEP HCCEEEEEECCCCCC	13.71	24719451
240	Phosphorylation	IIVYDENTNEPSRVM EEEEECCCCCCCCCC	38.62	24719451
313	Phosphorylation	LLPQPIPTTPDIENA CCCCCCCCCCCCCCC	52.24	28348404
314	Phosphorylation	LPQPIPTTPDIENAE CCCCCCCCCCCCCCC	17.38	28348404
380	Ubiquitination	LPATDSNKQNLRQYF CCCCCCCHHHHHHHH	44.51	29967540
415	Phosphorylation	CQAGVSRSATIVIAY CCCCCCHHHHHHHHH	23.43	20049867
417	Phosphorylation	AGVSRSATIVIAYLM CCCCHHHHHHHHHHH	19.61	20049867
422	Phosphorylation	SATIVIAYLMKHTRM HHHHHHHHHHHHCCC	9.01	20049867
427	Phosphorylation	IAYLMKHTRMTMTDA HHHHHHHCCCCHHHH	19.33	20049867
430	Phosphorylation	LMKHTRMTMTDAYKF HHHHCCCCHHHHHHH	17.39	20049867
432	Phosphorylation	KHTRMTMTDAYKFVK HHCCCCHHHHHHHHC	14.33	20049867
435	Phosphorylation	RMTMTDAYKFVKGKR CCCHHHHHHHHCCCC	14.04	20049867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
224	S	Phosphorylation	Kinase	MTOR	P42345	PSP
230	S	Phosphorylation	Kinase	MTOR	P42345	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DUS10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DUS10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK14_HUMAN	MAPK14	physical	10391943
MK08_HUMAN	MAPK8	physical	10391943
MK09_HUMAN	MAPK9	physical	11359773
MK10_HUMAN	MAPK10	physical	11359773
SNX2_HUMAN	SNX2	physical	21988832
FHL2_HUMAN	FHL2	physical	21988832
FINC_HUMAN	FN1	physical	21988832
RS11_HUMAN	RPS11	physical	21988832
SLX1_HUMAN	SLX1B	physical	21988832
CSKP_HUMAN	CASK	physical	27880917
MK09_HUMAN	MAPK9	physical	27880917
OTUD4_HUMAN	OTUD4	physical	27880917
ACTBL_HUMAN	ACTBL2	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
EFHD1_HUMAN	EFHD1	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DUS10_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, AND MASSSPECTROMETRY.	16565220 [Abstract]