dbPTM

SLX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SLX1_HUMAN
UniProt AC	Q9BQ83
Protein Name	Structure-specific endonuclease subunit SLX1 {ECO:0000255\|HAMAP-Rule:MF_03100}
Gene Name	SLX1A {ECO:0000255\|HAMAP-Rule:MF_03100}
Organism	Homo sapiens (Human).
Sequence Length	275
Subcellular Localization	Nucleus .
Protein Description	Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products..
Protein Sequence	MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQHNGGRKKGGAWRTSGRGPWEMVLVVHGFPSSVAALRFEWAWQHPHASRRLAHVGPRLRGETAFAFHLRVLAHMLRAPPWARLPLTLRWVRPDLRQDLCLPPPPHVPLAFGPPPPQAPAPRRRAGPFDDAEPEPDQGDPGACCSLCAQTIQDEEGPLCCPHPGCLLRAHVICLAEEFLQEEPGQLLPLEGQCPCCEKSLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
80	Methylation	PSSVAALRFEWAWQH CHHHHHHHHHHHHHC	23.78	115388341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SLX1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SLX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SLX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FKB10_HUMAN	FKBP10	physical	19596235
PAGR1_HUMAN	PAGR1	physical	19596235
GEMI4_HUMAN	GEMIN4	physical	19596235
PSB2_HUMAN	PSMB2	physical	19596235
SLX4_HUMAN	SLX4	physical	19596235
SLIRP_HUMAN	SLIRP	physical	19596235
PSB3_HUMAN	PSMB3	physical	19596235
XPF_HUMAN	ERCC4	physical	19596235
ERCC1_HUMAN	ERCC1	physical	19596235
PSA1_HUMAN	PSMA1	physical	19596235
GEMI6_HUMAN	GEMIN6	physical	19596235
TI17B_HUMAN	TIMM17B	physical	19596235
QCR2_HUMAN	UQCRC2	physical	19596235
SMN_HUMAN	SMN1	physical	19596235
S10A8_HUMAN	S100A8	physical	19596235
PSB5_HUMAN	PSMB5	physical	19596235
PSME3_HUMAN	PSME3	physical	19596235
SLX4I_HUMAN	SLX4IP	physical	19596235
PLK1_HUMAN	PLK1	physical	19596235
PSA2_HUMAN	PSMA2	physical	19596235
DDX20_HUMAN	DDX20	physical	19596235
MUS81_HUMAN	MUS81	physical	19596235
EME1_HUMAN	EME1	physical	19596235
RAN_HUMAN	RAN	physical	19596235
PSA3_HUMAN	PSMA3	physical	19596235
PSA7_HUMAN	PSMA7	physical	19596235
ANXA1_HUMAN	ANXA1	physical	19596235
PSA6_HUMAN	PSMA6	physical	19596235
PSA4_HUMAN	PSMA4	physical	19596235
PSB1_HUMAN	PSMB1	physical	19596235
HUWE1_HUMAN	HUWE1	physical	19596235
CUL1_HUMAN	CUL1	physical	19596235
CMC2_HUMAN	SLC25A13	physical	19596235
MYH11_HUMAN	MYH11	physical	19596235
PSMD6_HUMAN	PSMD6	physical	19596235
PSD11_HUMAN	PSMD11	physical	19596235
PSA5_HUMAN	PSMA5	physical	19596235
THA11_HUMAN	THAP11	physical	21988832
TBA1B_HUMAN	TUBA1B	physical	21988832
SLX4_HUMAN	SLX4	physical	24012755

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SLX1_HUMAN

Related Literatures of Post-Translational Modification