dbPTM

SLX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SLX4_HUMAN
UniProt AC	Q8IY92
Protein Name	Structure-specific endonuclease subunit SLX4
Gene Name	SLX4
Organism	Homo sapiens (Human).
Sequence Length	1834
Subcellular Localization	Nucleus . Localizes to sites of DNA damage.
Protein Description	Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks..
Protein Sequence	MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTRENVPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKMEVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTGRQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAWAMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGPSPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQDKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHEEDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQWDKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEVSASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDFLDTHCITFTTAATRREKLQGRRRQPRGKKKVERN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29 (in isoform 2)	Ubiquitination	-	49.41	21890473
57	Phosphorylation	DFKELCASFFQRVKK HHHHHHHHHHHHHHH	26.12	25159151
68	Sumoylation	RVKKHGIKEVSGERK HHHHCCCCCCCCCHH	57.57	28112733
71	Phosphorylation	KHGIKEVSGERKTQK HCCCCCCCCCHHHHH	35.71	-
113	Phosphorylation	PAEKKPPSGSQAPRT CCCCCCCCCCCCCCC	60.65	27732954
115	Phosphorylation	EKKPPSGSQAPRTKK CCCCCCCCCCCCCHH	27.75	27732954
126	Phosphorylation	RTKKQRVTKWQASEP CCHHHCCCCEECCCC	28.84	29888752
131	Phosphorylation	RVTKWQASEPAHSVN CCCCEECCCCCCCCC	29.07	29888752
136	Phosphorylation	QASEPAHSVNGEGGV ECCCCCCCCCCCCCE	21.27	29888752
146	Phosphorylation	GEGGVLASAPDPPVL CCCCEEECCCCCCCH	35.85	29888752
156	Phosphorylation	DPPVLRETAQNTQTG CCCCHHHHHHCCCCC	27.40	23186163
169	Phosphorylation	TGNQQEPSPNLSREK CCCCCCCCCCCCHHH	26.18	21815630
173	Phosphorylation	QEPSPNLSREKTREN CCCCCCCCHHHHHHC	45.06	-
177	Phosphorylation	PNLSREKTRENVPNS CCCCHHHHHHCCCCC	38.16	30576142
184	Phosphorylation	TRENVPNSDSQPPPS HHHCCCCCCCCCCCC	32.35	30576142
186	Phosphorylation	ENVPNSDSQPPPSCL HCCCCCCCCCCCCHH	44.39	27690223
191	Phosphorylation	SDSQPPPSCLTTAVP CCCCCCCCHHCCCCC	27.77	30266825
194	Phosphorylation	QPPPSCLTTAVPSPS CCCCCHHCCCCCCCC	19.62	30266825
195	Phosphorylation	PPPSCLTTAVPSPSK CCCCHHCCCCCCCCC	16.83	30266825
199	Phosphorylation	CLTTAVPSPSKPRTA HHCCCCCCCCCCHHH	34.90	23401153
201	Phosphorylation	TTAVPSPSKPRTAQL CCCCCCCCCCHHHHH	60.68	30266825
228	Phosphorylation	PERLRHASEECSLEA HHHHHHHCHHHHHHH	28.01	23401153
232	Phosphorylation	RHASEECSLEAAREE HHHCHHHHHHHHHHH	32.31	30108239
255	Phosphorylation	EMMAGNVYGLGPPAP HHHCCCCCCCCCCCC	15.61	-
264	Phosphorylation	LGPPAPESDAAVALT CCCCCCHHHHHHHHH	31.33	-
282	Phosphorylation	EFARVGASAHDDSLE HHHHHCCCCCCCCHH	21.87	27251275
287	Phosphorylation	GASAHDDSLEEKGLF CCCCCCCCHHHHCCE	43.68	29255136
291	Sumoylation	HDDSLEEKGLFFCQI CCCCHHHHCCEEHHH	52.09	-
291	Sumoylation	HDDSLEEKGLFFCQI CCCCHHHHCCEEHHH	52.09	28112733
291	Ubiquitination	HDDSLEEKGLFFCQI CCCCHHHHCCEEHHH	52.09	32015554
341	Ubiquitination	PECPICGKPFLTLKS CCCCCCCCEEEEECC	28.34	21890473
341 (in isoform 1)	Ubiquitination	-	28.34	21890473
347	Sumoylation	GKPFLTLKSRTSHLK CCEEEEECCCCHHHH	32.43	28112733
347	Ubiquitination	GKPFLTLKSRTSHLK CCEEEEECCCCHHHH	32.43	27667366
348	Phosphorylation	KPFLTLKSRTSHLKQ CEEEEECCCCHHHHH	43.85	-
354	Ubiquitination	KSRTSHLKQCAVKME CCCCHHHHHHCHHCC	37.60	-
359	Sumoylation	HLKQCAVKMEVGPQL HHHHHCHHCCCCHHH	15.72	-
359	Sumoylation	HLKQCAVKMEVGPQL HHHHHCHHCCCCHHH	15.72	28112733
359	Ubiquitination	HLKQCAVKMEVGPQL HHHHHCHHCCCCHHH	15.72	32015554
375	Phosphorylation	LQAVRLQTAQPEGSS HHHHHHHCCCCCCCC	31.67	27080861
381	Phosphorylation	QTAQPEGSSSPPMFS HCCCCCCCCCCCCCC	26.44	23401153
382	Phosphorylation	TAQPEGSSSPPMFSF CCCCCCCCCCCCCCC	58.69	30108239
383	Phosphorylation	AQPEGSSSPPMFSFS CCCCCCCCCCCCCCC	34.42	30108239
388	Phosphorylation	SSSPPMFSFSDHSRG CCCCCCCCCCCCCCC	20.00	27080861
390	Phosphorylation	SPPMFSFSDHSRGLK CCCCCCCCCCCCCCH	32.96	27080861
403	Phosphorylation	LKRRGPTSKKEPRKR CHHCCCCCCCCCCHH	44.88	27282143
404	"N6,N6-dimethyllysine"	KRRGPTSKKEPRKRR HHCCCCCCCCCCHHC	64.73	-
404	Methylation	KRRGPTSKKEPRKRR HHCCCCCCCCCCHHC	64.73	23644510
405	"N6,N6-dimethyllysine"	RRGPTSKKEPRKRRK HCCCCCCCCCCHHCC	73.12	-
405	Methylation	RRGPTSKKEPRKRRK HCCCCCCCCCCHHCC	73.12	23644510
412	Sumoylation	KEPRKRRKVDEAPSE CCCCHHCCCCCCCCH	59.06	28112733
412	Ubiquitination	KEPRKRRKVDEAPSE CCCCHHCCCCCCCCH	59.06	-
448	Phosphorylation	LRLESAFSERIRPEA HHHHHHHHHHCCHHH	26.19	24719451
458	Sumoylation	IRPEAENKSRKKKPP CCHHHHCCCCCCCCC	43.04	28112733
458	Ubiquitination	IRPEAENKSRKKKPP CCHHHHCCCCCCCCC	43.04	29967540
462	Ubiquitination	AENKSRKKKPPVSPP HHCCCCCCCCCCCCC	70.20	29967540
463	Ubiquitination	ENKSRKKKPPVSPPL HCCCCCCCCCCCCCE	58.55	29967540
467	Phosphorylation	RKKKPPVSPPLLLVQ CCCCCCCCCCEEEEE	26.95	30266825
476	Phosphorylation	PLLLVQDSETTGRQI CEEEEECCCCCCCCH	21.54	23403867
478	Phosphorylation	LLVQDSETTGRQIED EEEECCCCCCCCHHH	38.20	23403867
479	Phosphorylation	LVQDSETTGRQIEDR EEECCCCCCCCHHHH	26.73	23403867
492	Phosphorylation	DRVALLLSEEVELSS HHHHHHHCCCCCCCC	31.51	30301811
498	Phosphorylation	LSEEVELSSTPPLPA HCCCCCCCCCCCCCH	20.75	30266825
499	Phosphorylation	SEEVELSSTPPLPAS CCCCCCCCCCCCCHH	58.52	30266825
500	Phosphorylation	EEVELSSTPPLPASR CCCCCCCCCCCCHHH	26.08	30266825
506	Phosphorylation	STPPLPASRILKEGW CCCCCCHHHHHHHHH	20.22	26074081
510	Ubiquitination	LPASRILKEGWERAG CCHHHHHHHHHHHCC	52.38	29967540
523 (in isoform 2)	Ubiquitination	-	60.85	21890473
561	Ubiquitination	LVPQRPAQGLMQEPV CCCCCCCCCCCCCCC	48.51	22817900
563	Ubiquitination	PQRPAQGLMQEPVPP CCCCCCCCCCCCCCC	1.81	22817900
584	Phosphorylation	SELSERRSPALHGTP CHHHCCCCHHHCCCC	22.27	30266825
590	Phosphorylation	RSPALHGTPTAGCGS CCHHHCCCCCCCCCC	13.50	23663014
592	Phosphorylation	PALHGTPTAGCGSRG HHHCCCCCCCCCCCC	35.20	23663014
597	Phosphorylation	TPTAGCGSRGPSPSA CCCCCCCCCCCCCCH	37.83	23663014
601	Phosphorylation	GCGSRGPSPSASQRE CCCCCCCCCCHHHHH	34.02	27794612
603	Phosphorylation	GSRGPSPSASQREHQ CCCCCCCCHHHHHHH	44.91	23663014
605	Phosphorylation	RGPSPSASQREHQAL CCCCCCHHHHHHHHH	33.82	23663014
624	Phosphorylation	DLAREGLSASPWPGS HHHHCCCCCCCCCCC	37.24	27251275
626	Phosphorylation	AREGLSASPWPGSGG HHCCCCCCCCCCCCC	24.91	28348404
631	Phosphorylation	SASPWPGSGGLAGSE CCCCCCCCCCCCCCC	26.13	28348404
637	Phosphorylation	GSGGLAGSEGTAGLD CCCCCCCCCCCCCCC	27.52	28348404
640	Phosphorylation	GLAGSEGTAGLDVVP CCCCCCCCCCCCCCC	17.32	28348404
653	Phosphorylation	VPGGLPLTGFVVPSQ CCCCCCCCEEECCCC	27.00	28102081
659	Phosphorylation	LTGFVVPSQDKHPDR CCEEECCCCCCCCCC	39.13	28348404
832	Phosphorylation	DEEEEAETLLKSKDH CHHHHHHHHHHCCCH	44.42	-
835	Sumoylation	EEAETLLKSKDHEED HHHHHHHHCCCHHHH	59.58	28112733
835	Ubiquitination	EEAETLLKSKDHEED HHHHHHHHCCCHHHH	59.58	32015554
835 (in isoform 1)	Ubiquitination	-	59.58	21890473
836	Phosphorylation	EAETLLKSKDHEEDQ HHHHHHHCCCHHHHH	43.20	30266825
837	Ubiquitination	AETLLKSKDHEEDQE HHHHHHCCCHHHHHH	62.61	22817900
857 (in isoform 2)	Ubiquitination	-	2.92	21890473
863	Ubiquitination	EFAATQRKLLQEERA HHHHHHHHHHHHHHH	43.67	29967540
867 (in isoform 2)	Ubiquitination	-	49.79	21890473
884	Phosphorylation	ADWLEGGSPVSGQLL CHHHCCCCCCCCCCE	32.74	30278072
887	Phosphorylation	LEGGSPVSGQLLAGV HCCCCCCCCCCEEEE	24.98	30108239
893	Ubiquitination	VSGQLLAGVQVQKQW CCCCCEEEEEEECCC	15.45	22817900
895	Ubiquitination	GQLLAGVQVQKQWDK CCCEEEEEEECCCCC	30.88	22817900
902	Sumoylation	QVQKQWDKVEEMEPL EEECCCCCCHHCCCC	48.89	28112733
905	Ubiquitination	KQWDKVEEMEPLEPG CCCCCCHHCCCCCCC	52.40	22817900
906	Ubiquitination	QWDKVEEMEPLEPGR CCCCCHHCCCCCCCC	3.99	22817900
936	Phosphorylation	PPPQGQHSGARGAEA CCCCCCCCCCCCCCC	26.68	28555341
956	Phosphorylation	PEEALGHSSCSSPSR CHHHHCCCCCCCCCH	31.10	23401153
957	Phosphorylation	EEALGHSSCSSPSRD HHHHCCCCCCCCCHH	16.61	23401153
959	Phosphorylation	ALGHSSCSSPSRDCQ HHCCCCCCCCCHHHH	47.43	25159151
960	Phosphorylation	LGHSSCSSPSRDCQA HCCCCCCCCCHHHHH	31.08	23663014
962	Phosphorylation	HSSCSSPSRDCQAER CCCCCCCCHHHHHHH	42.57	23401153
970	Sumoylation	RDCQAERKEGSLPHS HHHHHHHHHCCCCCC	58.91	28112733
973	Phosphorylation	QAERKEGSLPHSDDA HHHHHHCCCCCCCCC	39.56	25921289
983	Phosphorylation	HSDDAGDYEQLFSST CCCCCCCHHHHHHCC	12.50	25921289
1028	Phosphorylation	RLAPWQASPPHPCRF CCCCCCCCCCCCCEE	24.70	30266825
1044	Phosphorylation	LGPPQGGSPRGSHHT ECCCCCCCCCCCCCC	20.46	19664994
1046	Methylation	PPQGGSPRGSHHTSG CCCCCCCCCCCCCCC	62.03	54559397
1061	Phosphorylation	SSLSTPRSRGGTSQV CCCCCCCCCCCCCCC	36.16	28450419
1062	Methylation	SLSTPRSRGGTSQVG CCCCCCCCCCCCCCC	49.17	115368357
1065	Phosphorylation	TPRSRGGTSQVGSPT CCCCCCCCCCCCCCC	20.86	21712546
1066	Phosphorylation	PRSRGGTSQVGSPTL CCCCCCCCCCCCCCC	26.58	25159151
1070	Phosphorylation	GGTSQVGSPTLLSPA CCCCCCCCCCCCCCC	18.82	30266825
1072	Phosphorylation	TSQVGSPTLLSPAVP CCCCCCCCCCCCCCC	41.87	30266825
1075	Phosphorylation	VGSPTLLSPAVPSKQ CCCCCCCCCCCCCCC	17.58	30266825
1080	Phosphorylation	LLSPAVPSKQKRDRS CCCCCCCCCCCCCCC	40.91	30266825
1081	Sumoylation	LSPAVPSKQKRDRSI CCCCCCCCCCCCCCE	54.49	28112733
1087	Phosphorylation	SKQKRDRSILTLSKE CCCCCCCCEEEECCC	26.66	30266825
1090	Phosphorylation	KRDRSILTLSKEPGH CCCCCEEEECCCCCC	27.58	28450419
1092	Phosphorylation	DRSILTLSKEPGHQK CCCEEEECCCCCCCC	29.72	21712546
1093	Sumoylation	RSILTLSKEPGHQKG CCEEEECCCCCCCCC	71.66	28112733
1093	Ubiquitination	RSILTLSKEPGHQKG CCEEEECCCCCCCCC	71.66	29967540
1105	Phosphorylation	QKGKERRSVLECRNK CCCCHHCCHHHHCCC	36.96	28258704
1112	Sumoylation	SVLECRNKGVLMFPE CHHHHCCCCEEECCC	30.92	28112733
1120	Sumoylation	GVLMFPEKSPSIDLT CEEECCCCCCCCCCC	68.83	28112733
1120	Ubiquitination	GVLMFPEKSPSIDLT CEEECCCCCCCCCCC	68.83	29967540
1121	Phosphorylation	VLMFPEKSPSIDLTQ EEECCCCCCCCCCCC	23.40	23186163
1123	Phosphorylation	MFPEKSPSIDLTQSN ECCCCCCCCCCCCCC	35.51	23186163
1127	Phosphorylation	KSPSIDLTQSNPDHS CCCCCCCCCCCCCCC	26.63	25278378
1129	Phosphorylation	PSIDLTQSNPDHSSS CCCCCCCCCCCCCCC	45.13	25278378
1134	Phosphorylation	TQSNPDHSSSRSQKS CCCCCCCCCCCCCCC	37.07	25278378
1135	Phosphorylation	QSNPDHSSSRSQKSS CCCCCCCCCCCCCCC	26.76	25278378
1136	Phosphorylation	SNPDHSSSRSQKSSS CCCCCCCCCCCCCCC	38.68	25278378
1138	Phosphorylation	PDHSSSRSQKSSSKL CCCCCCCCCCCCCCC	43.86	-
1157	Phosphorylation	EVILLLDSDEELELE CEEEEECCCHHHHHH	47.06	27732954
1167	Ubiquitination	ELELEQTKMKSISSD HHHHHHHHHHCCCCC	43.98	22817900
1169	Sumoylation	ELEQTKMKSISSDPL HHHHHHHHCCCCCCH	46.31	28112733
1169	Ubiquitination	ELEQTKMKSISSDPL HHHHHHHHCCCCCCH	46.31	22817900
1169 (in isoform 1)	Ubiquitination	-	46.31	21890473
1170	Phosphorylation	LEQTKMKSISSDPLE HHHHHHHCCCCCCHH	24.97	23663014
1172	Phosphorylation	QTKMKSISSDPLEEK HHHHHCCCCCCHHHH	35.46	23663014
1173	Phosphorylation	TKMKSISSDPLEEKK HHHHCCCCCCHHHHH	41.39	23663014
1179	Sumoylation	SSDPLEEKKALEISP CCCCHHHHHHHCCCH	33.69	28112733
1179	Ubiquitination	SSDPLEEKKALEISP CCCCHHHHHHHCCCH	33.69	27667366
1179 (in isoform 1)	Ubiquitination	-	33.69	21890473
1180	Sumoylation	SDPLEEKKALEISPR CCCHHHHHHHCCCHH	62.58	-
1180	Sumoylation	SDPLEEKKALEISPR CCCHHHHHHHCCCHH	62.58	28112733
1180	Ubiquitination	SDPLEEKKALEISPR CCCHHHHHHHCCCHH	62.58	22817900
1185	Phosphorylation	EKKALEISPRSCELF HHHHHCCCHHCEEEE	12.60	23401153
1188	Phosphorylation	ALEISPRSCELFSII HHCCCHHCEEEEEEE	18.48	30177828
1193	Phosphorylation	PRSCELFSIIDVDAD HHCEEEEEEEEECCC	31.12	30177828
1204	Phosphorylation	VDADQEPSQSPPRSE ECCCCCCCCCCCCHH	42.40	20873877
1206	Phosphorylation	ADQEPSQSPPRSEAV CCCCCCCCCCCHHHH	41.01	30278072
1210	Phosphorylation	PSQSPPRSEAVLQQE CCCCCCCHHHHHHHH	35.36	30177828
1243	Phosphorylation	WLFCDRESSPSEAST EEEECCCCCCCCCCC	48.74	28450419
1244	Phosphorylation	LFCDRESSPSEASTT EEECCCCCCCCCCCC	27.91	28450419
1246	Phosphorylation	CDRESSPSEASTTDT ECCCCCCCCCCCCCC	47.98	28450419
1249	Phosphorylation	ESSPSEASTTDTSWL CCCCCCCCCCCCCCE	27.99	28450419
1250	Phosphorylation	SSPSEASTTDTSWLV CCCCCCCCCCCCCEE	35.42	28450419
1251	Phosphorylation	SPSEASTTDTSWLVP CCCCCCCCCCCCEEE	34.48	28450419
1253	Phosphorylation	SEASTTDTSWLVPAT CCCCCCCCCCEEECC	21.51	28450419
1254	Phosphorylation	EASTTDTSWLVPATP CCCCCCCCCEEECCC	22.63	28450419
1260	Phosphorylation	TSWLVPATPLASRSR CCCEEECCCCCCCCC	16.86	27080861
1264	Phosphorylation	VPATPLASRSRDCSS EECCCCCCCCCCCCC	38.17	-
1271	Phosphorylation	SRSRDCSSQTQISSL CCCCCCCCHHHHHHH	43.51	26714015
1273	Phosphorylation	SRDCSSQTQISSLRS CCCCCCHHHHHHHHH	29.80	26714015
1276	Phosphorylation	CSSQTQISSLRSGLA CCCHHHHHHHHHCCH	17.32	24719451
1277	Phosphorylation	SSQTQISSLRSGLAV CCHHHHHHHHHCCHH	29.45	25954137
1288	Phosphorylation	GLAVQAVTQHTPRAS CCHHHHHHHCCCCCC	20.04	25159151
1291	Phosphorylation	VQAVTQHTPRASVGN HHHHHHCCCCCCCCC	12.49	25159151
1295	Phosphorylation	TQHTPRASVGNREGN HHCCCCCCCCCCCCC	31.66	28555341
1309	Phosphorylation	NEVAQKFSVIRPQTP CHHHHHHCEECCCCC	24.54	29255136
1315	Phosphorylation	FSVIRPQTPPPQTPS HCEECCCCCCCCCCC	40.21	23401153
1320	Phosphorylation	PQTPPPQTPSSCLTP CCCCCCCCCCCCCCC	30.80	29255136
1322	Phosphorylation	TPPPQTPSSCLTPVS CCCCCCCCCCCCCCC	36.75	23401153
1323	Phosphorylation	PPPQTPSSCLTPVSP CCCCCCCCCCCCCCC	17.85	29255136
1326	Phosphorylation	QTPSSCLTPVSPGTS CCCCCCCCCCCCCCC	26.43	30266825
1329	Phosphorylation	SSCLTPVSPGTSDGR CCCCCCCCCCCCCCC	20.86	23401153
1332	Phosphorylation	LTPVSPGTSDGRRQG CCCCCCCCCCCCCCC	27.33	30266825
1333	Phosphorylation	TPVSPGTSDGRRQGH CCCCCCCCCCCCCCC	43.94	30266825
1342	Phosphorylation	GRRQGHRSPSRPHPG CCCCCCCCCCCCCCC	22.89	29255136
1344	Phosphorylation	RQGHRSPSRPHPGGH CCCCCCCCCCCCCCC	60.74	29255136
1345 (in isoform 2)	Ubiquitination	-	36.61	21890473
1354	Phosphorylation	HPGGHPHSSPLAPHP CCCCCCCCCCCCCCC	37.79	27080861
1355	Phosphorylation	PGGHPHSSPLAPHPI CCCCCCCCCCCCCCC	22.39	27794612
1363	Phosphorylation	PLAPHPISGDRAHFS CCCCCCCCCCCHHHH	38.81	27080861
1377	Phosphorylation	SRRFLKHSPPGPSFL HHHHHHCCCCCCCCC	31.07	27732954
1382	Phosphorylation	KHSPPGPSFLNQTPA HCCCCCCCCCCCCCC	48.56	27732954
1383	Ubiquitination	HSPPGPSFLNQTPAG CCCCCCCCCCCCCCC	9.27	22817900
1387	Phosphorylation	GPSFLNQTPAGEVVE CCCCCCCCCCCCEEE	17.65	27732954
1387	Ubiquitination	GPSFLNQTPAGEVVE CCCCCCCCCCCCEEE	17.65	22817900
1398	Phosphorylation	EVVEVGDSDDEQEVA CEEEECCCCCHHHHH	40.82	20873877
1406	Phosphorylation	DDEQEVASHQANRSP CCHHHHHHHHCCCCC	22.70	27732954
1446	Phosphorylation	DHWNLERTGPLSTSS CCCCCHHCCCCCCCC	33.50	30266825
1450	Phosphorylation	LERTGPLSTSSPSRR CHHCCCCCCCCCCHH	29.40	30266825
1451	Phosphorylation	ERTGPLSTSSPSRRM HHCCCCCCCCCCHHH	40.69	30266825
1452	Phosphorylation	RTGPLSTSSPSRRMN HCCCCCCCCCCHHHH	36.55	30266825
1453	Phosphorylation	TGPLSTSSPSRRMNE CCCCCCCCCCHHHHH	27.30	30266825
1455	Phosphorylation	PLSTSSPSRRMNEAA CCCCCCCCHHHHHHH	34.17	30266825
1464	Phosphorylation	RMNEAADSRDCRSPG HHHHHHHHCCCCCCC	25.87	-
1469	Phosphorylation	ADSRDCRSPGLLDTT HHHCCCCCCCCCCCC	29.65	19664994
1475	Phosphorylation	RSPGLLDTTPIRGSC CCCCCCCCCCCCCCC	34.15	30266825
1476	Phosphorylation	SPGLLDTTPIRGSCT CCCCCCCCCCCCCCH	19.18	30266825
1481	Phosphorylation	DTTPIRGSCTTQRKL CCCCCCCCCHHHHHH	9.84	26074081
1483	Phosphorylation	TPIRGSCTTQRKLQE CCCCCCCHHHHHHHH	27.88	26074081
1484	Phosphorylation	PIRGSCTTQRKLQEK CCCCCCHHHHHHHHH	30.61	26074081
1491	Ubiquitination	TQRKLQEKSSGAGSL HHHHHHHHCCCCCCC	36.64	29967540
1561	Phosphorylation	LPPKVPITPMPQYSI CCCCCCCCCCCCCCC	13.89	23663014
1566	Phosphorylation	PITPMPQYSIMETPV CCCCCCCCCCCCCHH	8.36	23663014
1567	Phosphorylation	ITPMPQYSIMETPVL CCCCCCCCCCCCHHH	15.37	23663014
1571	Phosphorylation	PQYSIMETPVLKKEL CCCCCCCCHHHHHHH	11.00	23663014
1575	Sumoylation	IMETPVLKKELDRFG CCCCHHHHHHHHHHC	44.42	-
1575	Sumoylation	IMETPVLKKELDRFG CCCCHHHHHHHHHHC	44.42	28112733
1576	Sumoylation	METPVLKKELDRFGV CCCHHHHHHHHHHCC	60.39	28112733
1608	Phosphorylation	YTHQTLDSDSEDESQ HHHHCCCCCCCCCHH	46.26	28348404
1610	Phosphorylation	HQTLDSDSEDESQSS HHCCCCCCCCCHHHC	51.39	28348404
1614	Phosphorylation	DSDSEDESQSSQPLL CCCCCCCHHHCCCCH	47.92	28348404
1616	Phosphorylation	DSEDESQSSQPLLQA CCCCCHHHCCCCHHC	39.97	28348404
1617	Phosphorylation	SEDESQSSQPLLQAP CCCCHHHCCCCHHCC	28.34	28348404
1631	Phosphorylation	PHCQTLASQTYKPSR CCHHHHHCCCCCCCC	26.60	-
1649	Phosphorylation	HAQQEATTGPGAHRP CCCCCCCCCCCCCCC	48.72	28555341
1656	Ubiquitination	TGPGAHRPKGPAKTK CCCCCCCCCCCCCCC	35.77	22817900
1657	Sumoylation	GPGAHRPKGPAKTKG CCCCCCCCCCCCCCC	76.97	28112733
1657	Ubiquitination	GPGAHRPKGPAKTKG CCCCCCCCCCCCCCC	76.97	22817900
1657 (in isoform 1)	Ubiquitination	-	76.97	21890473
1660	Ubiquitination	AHRPKGPAKTKGPRH CCCCCCCCCCCCCCH	40.60	22817900
1661	Ubiquitination	HRPKGPAKTKGPRHQ CCCCCCCCCCCCCHH	54.63	22817900
1674	Phosphorylation	HQRKHHESITPPSRS HHHHCCCCCCCCCCC	27.66	20363803
1676	Phosphorylation	RKHHESITPPSRSPT HHCCCCCCCCCCCCC	38.12	25159151
1679	Phosphorylation	HESITPPSRSPTKEA CCCCCCCCCCCCCCC	46.74	25159151
1681	Phosphorylation	SITPPSRSPTKEAPP CCCCCCCCCCCCCCC	41.06	25159151
1683	Phosphorylation	TPPSRSPTKEAPPGL CCCCCCCCCCCCCCC	42.64	23663014
1716	Phosphorylation	GSDSSLSSQSSSSCE CCCCCCCCCCCCCCC	39.10	-
1803	Phosphorylation	RLLDFLDTHCITFTT HHHHHHHHCCEEEEC	22.31	26552605
1807	Phosphorylation	FLDTHCITFTTAATR HHHHCCEEEECHHHH	21.96	26552605
1809	Phosphorylation	DTHCITFTTAATRRE HHCCEEEECHHHHHH	13.58	26552605
1810	Phosphorylation	THCITFTTAATRREK HCCEEEECHHHHHHH	15.31	26552605
1813	Phosphorylation	ITFTTAATRREKLQG EEEECHHHHHHHHCC	28.00	26552605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1138	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1271	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1631	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1716	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SLX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SLX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCA10_HUMAN	DCAF10	physical	19596235
XPF_HUMAN	ERCC4	physical	19596235
ERCC1_HUMAN	ERCC1	physical	19596235
PNMA2_HUMAN	PNMA2	physical	19596235
TSYL1_HUMAN	TSPYL1	physical	19596235
PLK1_HUMAN	PLK1	physical	19596235
MUS81_HUMAN	MUS81	physical	19596235
TERF2_HUMAN	TERF2	physical	19596235
SLX1_HUMAN	SLX1B	physical	19596235
NU188_HUMAN	NUP188	physical	19596235
EME1_HUMAN	EME1	physical	19596235
TEX10_HUMAN	TEX10	physical	19596235
NUP50_HUMAN	NUP50	physical	19596235
NOP53_HUMAN	GLTSCR2	physical	19596235
SLX4I_HUMAN	SLX4IP	physical	19596235
TE2IP_HUMAN	TERF2IP	physical	19596235
PSB4_HUMAN	PSMB4	physical	19596235
LRRC1_HUMAN	LRRC1	physical	19596235
GID8_HUMAN	GID8	physical	19596235
PGAM5_HUMAN	PGAM5	physical	19596235
IMA5_HUMAN	KPNA1	physical	19596235
MSH2_HUMAN	MSH2	physical	19596235
MSH3_HUMAN	MSH3	physical	19596235
MSH2_HUMAN	MSH2	physical	22902628
MSH6_HUMAN	MSH6	physical	22902628
DDB1_HUMAN	DDB1	physical	22902628
TERA_HUMAN	VCP	physical	22902628
MUS81_HUMAN	MUS81	physical	22902628
XPF_HUMAN	ERCC4	physical	22902628
TE2IP_HUMAN	TERF2IP	physical	22902628
PLK1_HUMAN	PLK1	physical	22902628
ERCC1_HUMAN	ERCC1	physical	22902628
PCNA_HUMAN	PCNA	physical	22902628
SLX4I_HUMAN	SLX4IP	physical	22902628
SPRTN_HUMAN	SPRTN	physical	22902628
XPF_HUMAN	ERCC4	physical	21240275
ERCC1_HUMAN	ERCC1	physical	21240275
MUS81_HUMAN	MUS81	physical	21240275
XPF_HUMAN	ERCC4	physical	19595722
XPF_HUMAN	ERCC4	physical	19595721
ERCC1_HUMAN	ERCC1	physical	19595721
MUS81_HUMAN	MUS81	physical	19595721
EME1_HUMAN	EME1	physical	19595721
XPF_HUMAN	ERCC4	physical	19596236
MUS81_HUMAN	MUS81	physical	19596236
A4_HUMAN	APP	physical	21832049
XPF_HUMAN	ERCC4	physical	23093618
ERCC1_HUMAN	ERCC1	physical	23093618
MUS81_HUMAN	MUS81	physical	23093618
UBC_HUMAN	UBC	physical	24794496
DCR1B_HUMAN	DCLRE1B	physical	22907656
TERF2_HUMAN	TERF2	physical	23994477
XPF_HUMAN	ERCC4	physical	23994477
MUS81_HUMAN	MUS81	physical	23994477
TERF2_HUMAN	TERF2	physical	24012755
XPF_HUMAN	ERCC4	physical	24012755
MUS81_HUMAN	MUS81	physical	24012755
SLX1_HUMAN	SLX1B	physical	24012755
TOPB1_HUMAN	TOPBP1	physical	25030699
MUS81_HUMAN	MUS81	physical	25224045
SUMO2_HUMAN	SUMO2	physical	25533185
TERF2_HUMAN	TERF2	physical	25533185
MUS81_HUMAN	MUS81	physical	25533185
MRE11_HUMAN	MRE11A	physical	25533185
NBN_HUMAN	NBN	physical	25533185
RFA1_HUMAN	RPA1	physical	25533185
SUMO2_HUMAN	SUMO2	physical	25533188
SUMO3_HUMAN	SUMO3	physical	25533188
SUMO1_HUMAN	SUMO1	physical	25533188
UBC9_HUMAN	UBE2I	physical	25533188
ERCC1_HUMAN	ERCC1	physical	23033263
MUS81_HUMAN	MUS81	physical	23033263
XPF_HUMAN	ERCC4	physical	23033263
SLX4_HUMAN	SLX4	physical	23033263
SLX4_HUMAN	SLX4	physical	27131364
FACD2_HUMAN	FANCD2	physical	21464321
XPF_HUMAN	ERCC4	physical	23623386
ERCC1_HUMAN	ERCC1	physical	23623386
MUS81_HUMAN	MUS81	physical	23623386

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613951	Fanconi anemia complementation group P (FANCP)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SLX4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1452, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-1469, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1469, AND MASSSPECTROMETRY.	18220336 [Abstract]