MUS81_HUMAN - dbPTM
MUS81_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MUS81_HUMAN
UniProt AC Q96NY9
Protein Name Crossover junction endonuclease MUS81
Gene Name MUS81
Organism Homo sapiens (Human).
Sequence Length 551
Subcellular Localization Nucleus, nucleolus . Recruited to foci of DNA damage in S-phase cells.
Protein Description Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks..
Protein Sequence MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationTEWRDEATRSRRRTR
HHHHHHHHHHHHHHH		27.4226074081
35PhosphorylationWRDEATRSRRRTRFV
HHHHHHHHHHHHHHH		26.2826074081
45UbiquitinationRTRFVFQKALRSLRR
HHHHHHHHHHHHHHC		37.61-
49PhosphorylationVFQKALRSLRRYPLP
HHHHHHHHHHCCCCC		27.3826670566
53PhosphorylationALRSLRRYPLPLRSG
HHHHHHCCCCCCCCC		11.5920860994
64UbiquitinationLRSGKEAKILQHFGD
CCCCCHHHHHHHHHH		45.07-
86PhosphorylationERLQRHRTSGGDHAP
HHHHHHHCCCCCCCC		26.1229255136
87PhosphorylationRLQRHRTSGGDHAPD
HHHHHHCCCCCCCCC		40.5129255136
95PhosphorylationGGDHAPDSPSGENSP
CCCCCCCCCCCCCCC		21.6529255136
97PhosphorylationDHAPDSPSGENSPAP
CCCCCCCCCCCCCCC		63.7929255136
101PhosphorylationDSPSGENSPAPQGRL
CCCCCCCCCCCCCCC		20.3823401153
114PhosphorylationRLAEVQDSSMPVPAQ
CCEEECCCCCCCCCC		16.0828555341
115PhosphorylationLAEVQDSSMPVPAQP
CEEECCCCCCCCCCC		35.0820860994
123UbiquitinationMPVPAQPKAGGSGSY
CCCCCCCCCCCCCCC		47.81-
136PhosphorylationSYWPARHSGARVILL
CCCCCCCCCCEEEEE		28.70-
159PhosphorylationPNGHHFLTKEELLQR
CCCCCCCCHHHHHHH		35.1521406692
171PhosphorylationLQRCAQKSPRVAPGS
HHHHHHHCCCCCCCC		13.0823663014
178PhosphorylationSPRVAPGSARPWPAL
CCCCCCCCCCCHHHH		21.7523663014
197PhosphorylationHRNLVLRTHQPARYS
HCCCCCCCCCCCCCC		22.2430576142
203PhosphorylationRTHQPARYSLTPEGL
CCCCCCCCCCCHHHH		15.3322210691
204PhosphorylationTHQPARYSLTPEGLE
CCCCCCCCCCHHHHH		21.8830576142
335UbiquitinationLDHIVERKRLDDLCS
HHHHHHHHCHHHHHH		43.75-
406UbiquitinationVKRTADIKESAAYLA
EEECCCHHHHHHHHH		46.28-
408PhosphorylationRTADIKESAAYLALL
ECCCHHHHHHHHHHH		17.1324719451
411PhosphorylationDIKESAAYLALLTRG
CHHHHHHHHHHHHHH		7.6921406692
416PhosphorylationAAYLALLTRGLQRLY
HHHHHHHHHHHHHHH		24.4421406692
489UbiquitinationVRGVSGEKAAALVDR
HHCCCHHHHHHHHHC		47.02-
499PhosphorylationALVDRYSTPASLLAA
HHHHCCCCHHHHHHH		17.5924719451
502PhosphorylationDRYSTPASLLAAYDA
HCCCCHHHHHHHHHH		25.7222210691
507PhosphorylationPASLLAAYDACATPK
HHHHHHHHHHCCCHH		9.8522210691
512PhosphorylationAAYDACATPKEQETL
HHHHHCCCHHHHHHH		34.4722210691
524UbiquitinationETLLSTIKCGRLQRN
HHHHHHHHHCHHHHH		30.63-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
87SPhosphorylationKinaseCSNK2A1P68400
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MUS81_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MUS81_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EME1_HUMANEME1physical
12721304
CHK2_HUMANCHEK2physical
11741546
TERT_HUMANTERTgenetic
19363487
TERF2_HUMANTERF2physical
19363487
WEE1_HUMANWEE1physical
21859861
EME1_HUMANEME1physical
21962513
PLK1_HUMANPLK1physical
21962513
SLX4_HUMANSLX4physical
24012755
SLX4_HUMANSLX4physical
25416956
UHRF1_HUMANUHRF1physical
25818288
EME1_HUMANEME1physical
19363487
CBP_HUMANCREBBPgenetic
24104479
ZN496_HUMANZNF496genetic
24104479
AT7L1_HUMANATXN7L1genetic
24104479
ZN181_HUMANZNF181genetic
24104479
BRD9_HUMANBRD9genetic
24104479
LTK_HUMANLTKgenetic
24104479
TM209_HUMANTMEM209genetic
24104479
ZNF17_HUMANZNF17genetic
24104479
ZN358_HUMANZNF358genetic
24104479
FACD2_HUMANFANCD2genetic
24104479
TCPH_HUMANCCT7genetic
24104479
PLEK2_HUMANPLEK2genetic
24104479
TRAF6_HUMANTRAF6genetic
24104479
CK5P2_HUMANCDK5RAP2genetic
24104479
DPOD2_HUMANPOLD2genetic
24104479
SREK1_HUMANSREK1genetic
24104479
TIM_HUMANTIMELESSgenetic
24104479
RPAB5_HUMANPOLR2Lgenetic
24104479
DNJB9_HUMANDNAJB9genetic
24104479
RS3_HUMANRPS3genetic
24104479
IMA7_HUMANKPNA6genetic
24104479
TFB1M_HUMANTFB1Mgenetic
24104479
TIF1A_HUMANTRIM24genetic
24104479
RAMP1_HUMANRAMP1genetic
24104479
BRAF_HUMANBRAFgenetic
24104479
STIL_HUMANSTILgenetic
24104479
ZN142_HUMANZNF142genetic
24104479
RFC1_HUMANRFC1genetic
24104479
IDHP_HUMANIDH2genetic
24104479
DDX23_HUMANDDX23genetic
24104479
GTPB8_HUMANGTPBP8genetic
24104479
MDFI_HUMANMDFIgenetic
24104479
WRN_HUMANWRNgenetic
24104479
SMAG2_HUMANSAMD4Bgenetic
24104479
DUS3L_HUMANDUS3Lgenetic
24104479
INO80_HUMANINO80genetic
24104479
ALMS1_HUMANALMS1genetic
24104479
SNW1_HUMANSNW1genetic
24104479
PIGB_HUMANPIGBgenetic
24104479
TERA_HUMANVCPgenetic
24104479
RPC10_HUMANPOLR3Kgenetic
24104479
XIAP_HUMANXIAPgenetic
24104479
ELK4_HUMANELK4genetic
24104479
RFTN1_HUMANRFTN1genetic
24104479
BL1S1_HUMANBLOC1S1genetic
24104479
SFPQ_HUMANSFPQgenetic
24104479
K2026_HUMANKIAA2026genetic
24104479
VWCE_HUMANVWCEgenetic
24104479
MBP_HUMANMBPgenetic
24104479
PCX2_HUMANPCNXL2genetic
24104479
SF3A2_HUMANSF3A2genetic
24104479
SLX4_HUMANSLX4physical
21516116
SLX4_HUMANSLX4physical
25224045
EME1_HUMANEME1physical
25224045
EME1_HUMANEME1physical
28514442
XPF_HUMANERCC4physical
28514442
SLX4_HUMANSLX4physical
28514442
ERCC1_HUMANERCC1physical
28514442
RRP44_HUMANDIS3physical
28514442
EME1_HUMANEME1physical
25319828
DCAF1_HUMANVPRBPphysical
27354282
EME1_HUMANEME1physical
27354282
DDB1_HUMANDDB1physical
27354282
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MUS81_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASSSPECTROMETRY.

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