PLEK2_HUMAN - dbPTM
PLEK2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLEK2_HUMAN
UniProt AC Q9NYT0
Protein Name Pleckstrin-2
Gene Name PLEK2
Organism Homo sapiens (Human).
Sequence Length 353
Subcellular Localization Cell projection, lamellipodium membrane
Peripheral membrane protein. Cytoplasm, cytoskeleton.
Protein Description May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation..
Protein Sequence MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITCPCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNSFKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEAVTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEDGVLKE
-------CCCCCEEE		10.7922814378
13UbiquitinationLKEGFLVKRGHIVHN
EEEEEEEECCEEEEE		55.6027667366
32PhosphorylationWFILRQNTLVYYKLE
EEEEECCEEEEEEEE		14.84-
48UbiquitinationGRRVTPPKGRILLDG
CCCCCCCCCCEEEEC		63.1227667366
116PhosphorylationGKVQQLHSLRNSFKL
CCHHHHHHHHHHCCC		37.3020815410
120PhosphorylationQLHSLRNSFKLPPHI
HHHHHHHHCCCCCCC		19.8230266825
128PhosphorylationFKLPPHISLHRIVDK
CCCCCCCCHHHHHHH		18.3223312004
135UbiquitinationSLHRIVDKMHDSNTG
CHHHHHHHHCCCCCC		27.5222817900
145PhosphorylationDSNTGIRSSPNMEQG
CCCCCCCCCCCCCCC		48.5025627689
146PhosphorylationSNTGIRSSPNMEQGS
CCCCCCCCCCCCCCC		15.5025159151
153PhosphorylationSPNMEQGSTYKKTFL
CCCCCCCCEECCCCC		28.4024043423
154PhosphorylationPNMEQGSTYKKTFLG
CCCCCCCEECCCCCC		46.3024043423
155PhosphorylationNMEQGSTYKKTFLGS
CCCCCCEECCCCCCH		16.5124043423
156UbiquitinationMEQGSTYKKTFLGSS
CCCCCEECCCCCCHH		45.4821906983
157UbiquitinationEQGSTYKKTFLGSSL
CCCCEECCCCCCHHH		33.8122817900
185PhosphorylationLEAVTLASMLMEENF
HHHHHHHHHHHHHCC		18.6326074081
200PhosphorylationLRPVGVRSMGAIRSG
CCCCCCCCCCCCCCC		21.1124719451
221PhosphorylationLDDSTALYTFAESYK
CCCCHHHHHHHHHHH		9.4327642862
234SumoylationYKKKISPKEEISLST
HHCCCCCHHHCCCEE		62.28-
234SumoylationYKKKISPKEEISLST
HHCCCCCHHHCCCEE		62.28-
240PhosphorylationPKEEISLSTVELSGT
CHHHCCCEEEEECCE		24.5028348404
241PhosphorylationKEEISLSTVELSGTV
HHHCCCEEEEECCEE		24.2428348404
247PhosphorylationSTVELSGTVVKQGYL
EEEEECCEEEECCEE		20.81-
256UbiquitinationVKQGYLAKQGHKRKN
EECCEECCCCCCCCC		54.9727667366
280PhosphorylationKDPAFLHYYDPSKEE
CCCCCEEECCCCCCC		16.2327259358
280UbiquitinationKDPAFLHYYDPSKEE
CCCCCEEECCCCCCC		16.2321963094
281PhosphorylationDPAFLHYYDPSKEEN
CCCCEEECCCCCCCC		15.6122817900
295PhosphorylationNRPVGGFSLRGSLVS
CCCCCCEEECCHHHH		22.0424719451
305UbiquitinationGSLVSALEDNGVPTG
CHHHHHHHHCCCCCC		49.5021963094
314UbiquitinationNGVPTGVKGNVQGNL
CCCCCCCCCCCCCCE		46.2221906983
316UbiquitinationVPTGVKGNVQGNLFK
CCCCCCCCCCCCEEE		19.7427667366
326PhosphorylationGNLFKVITKDDTHYY
CCEEEEEECCCCCEE		31.26-
330PhosphorylationKVITKDDTHYYIQAS
EEEECCCCCEEEECC		23.1628102081
332PhosphorylationITKDDTHYYIQASSK
EECCCCCEEEECCCH		12.3528102081
333PhosphorylationTKDDTHYYIQASSKA
ECCCCCEEEECCCHH		4.4822817900
339UbiquitinationYYIQASSKAERAEWI
EEEECCCHHHHHHHH		52.3421906983
350UbiquitinationAEWIEAIKKLT----
HHHHHHHHHHC----		49.1027667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLEK2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLEK2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLEK2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHIP2_HUMANINPPL1physical
22939629
RS19_HUMANRPS19physical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLEK2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-333, AND MASSSPECTROMETRY.

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