PIGB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIGB_HUMAN
• UniProt AC: Q92521
• Protein Name: GPI mannosyltransferase 3
• Gene Name: PIGB
• Organism: Homo sapiens (Human).
• Sequence Length: 554
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly..
• Protein Sequence: MRRPLSKCGMEPGGGDASLTLHGLQNRSHGKIKLRKRKSTLYFNTQEKSARRRGDLLGENIYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGRIGSHIYVYERKLKGKFNMKMKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRRPLSKCGMEPG --CCCCHHHCCCCCC	28.69	24719451
18	Phosphorylation	EPGGGDASLTLHGLQ CCCCCCCCEEHHCCC	26.99	29083192
20	Phosphorylation	GGGDASLTLHGLQNR CCCCCCEEHHCCCCC	17.76	29083192
26	N-linked_Glycosylation	LTLHGLQNRSHGKIK EEHHCCCCCCCCCEE	53.09	UniProtKB CARBOHYD
39	Phosphorylation	IKLRKRKSTLYFNTQ EEECCCCCEEEEECH	27.90	23401153
40	Phosphorylation	KLRKRKSTLYFNTQE EECCCCCEEEEECHH	28.63	30266825
42	Phosphorylation	RKRKSTLYFNTQEKS CCCCCEEEEECHHHH	8.55	28796482
45	Phosphorylation	KSTLYFNTQEKSARR CCEEEEECHHHHHHH	28.36	30266825
48	Ubiquitination	LYFNTQEKSARRRGD EEEECHHHHHHHHHC	39.33	21963094
114	Phosphorylation	EWTERLRSYTYPLIF HHHHHHHHCCHHHHH	26.81	30206219
115	Phosphorylation	WTERLRSYTYPLIFA HHHHHHHCCHHHHHH	12.12	30206219
116	Phosphorylation	TERLRSYTYPLIFAS HHHHHHCCHHHHHHH	21.65	30206219
117	Phosphorylation	ERLRSYTYPLIFASI HHHHHCCHHHHHHHH	6.44	30206219
123	Phosphorylation	TYPLIFASIYKILHL CHHHHHHHHHHHHHH	18.72	30206219
125	Phosphorylation	PLIFASIYKILHLLG HHHHHHHHHHHHHHC	6.89	30206219
234	Phosphorylation	LAFIIRPTAVILWTP HHHHHCCHHHHHHHH	24.57	-
240	Phosphorylation	PTAVILWTPLLFRHF CHHHHHHHHHHHHHH	10.70	-
244	Ubiquitination	ILWTPLLFRHFCQEP HHHHHHHHHHHCCCC	8.21	21963094
259	Ubiquitination	RKLDLILHHFLPVGF HHHHHHHHHCCCCCH	11.58	21963094
287	Ubiquitination	FGQWTLVQFNFLKFN HCCEEEEEEECEECE	30.58	21963094
356	Phosphorylation	LLVYSMLSHKEFRFI HHHHHHHCCCCHHHH	24.70	-
385	Ubiquitination	LTHLKTWKKPALSFL HHHHHCCCCHHHHHH	54.86	21963094
402	Phosphorylation	SNLFLALYTGLVHQR HHHHHHHHHCHHHCC	7.99	18083107
405	Ubiquitination	FLALYTGLVHQRGTL HHHHHHCHHHCCCHH	2.10	21963094
420	Ubiquitination	DVMSHIQKVCYNNPN HHHHHHHHHHHCCCC	33.40	21963094
427	N-linked_Glycosylation	KVCYNNPNKSSASIF HHHHCCCCCCCEEEE	59.99	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIGB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIGB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIGB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PIGB_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.