ZN181_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN181_HUMAN
• UniProt AC: Q2M3W8
• Protein Name: Zinc finger protein 181
• Gene Name: ZNF181
• Organism: Homo sapiens (Human).
• Sequence Length: 571
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MPQVTFNDVAIDFTHEEWGWLSSAQRDLYKDVMVQNYENLVSVAGLSVTKPYVITLLEDGKEPWMMEKKLSKGMIPDWESRWENKELSTKKDNYDEDSPQTVIIEKVVKQSYEFSNSKKNLEYIEKLEGKHGSQVDHFRPAILTSRESPTADSVYKYNIFRSTFHSKSTLSEPQKISAEGNSHKYDILKKNLPKKSVIKNEKVNGGKKLLNSNKSGAAFSQGKSLTLPQTCNREKIYTCSECGKAFGKQSILNRHWRIHTGEKPYECRECGKTFSHGSSLTRHLISHSGEKPYKCIECGKAFSHVSSLTNHQSTHTGEKPYECMNCGKSFSRVSHLIEHLRIHTQEKLYECRICGKAFIHRSSLIHHQKIHTGEKPYECRECGKAFCCSSHLTRHQRIHTMEKQYECNKCLKVFSSLSFLVQHQSIHTEEKPFECQKCRKSFNQLESLNMHLRNHIRLKPYECSICGKAFSHRSSLLQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQRIHTGEKPYKCNECGKAFSKGSNLTAHQRVHNGEKPNSVVSVEKPLDYMNHYTCEKSYRRETV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Sumoylation	VIIEKVVKQSYEFSN EEEEHHHHHHHCCCC	36.19	-
109	Sumoylation	VIIEKVVKQSYEFSN EEEEHHHHHHHCCCC	36.19	25218447
126	Sumoylation	KNLEYIEKLEGKHGS HHHHHHHHHCCCCCC	42.13	28112733
126	Ubiquitination	KNLEYIEKLEGKHGS HHHHHHHHHCCCCCC	42.13	-
144	Phosphorylation	HFRPAILTSRESPTA CCCCCHHCCCCCCCC	21.45	24719451
145	Phosphorylation	FRPAILTSRESPTAD CCCCHHCCCCCCCCC	30.52	-
148	Phosphorylation	AILTSRESPTADSVY CHHCCCCCCCCCCCH	26.83	-
153	Phosphorylation	RESPTADSVYKYNIF CCCCCCCCCHHHEEH	25.53	-
182	Phosphorylation	KISAEGNSHKYDILK EECCCCCHHHHHHHH	32.01	22985185
185	Phosphorylation	AEGNSHKYDILKKNL CCCCHHHHHHHHHCC	11.64	25884760
214	Sumoylation	KKLLNSNKSGAAFSQ HHCCCCCCCCCCCCC	50.52	-
214	Sumoylation	KKLLNSNKSGAAFSQ HHCCCCCCCCCCCCC	50.52	-
224	Phosphorylation	AAFSQGKSLTLPQTC CCCCCCCCCCCCCCC	33.15	28555341
248	Ubiquitination	ECGKAFGKQSILNRH HHHHHHCCHHHHHCC	34.12	-
260	Phosphorylation	NRHWRIHTGEKPYEC HCCCEEECCCCCEEC	44.67	28111955
286	Phosphorylation	SLTRHLISHSGEKPY HHHHHHHHCCCCCCE	20.26	28348404
288	Phosphorylation	TRHLISHSGEKPYKC HHHHHHCCCCCCEEE	41.69	28348404
321	Phosphorylation	THTGEKPYECMNCGK CCCCCCCEECCCCCC	32.59	21406692
329	Phosphorylation	ECMNCGKSFSRVSHL ECCCCCCCHHHHHHH	17.46	21406692
331	Phosphorylation	MNCGKSFSRVSHLIE CCCCCCHHHHHHHHH	38.57	21406692
334	Phosphorylation	GKSFSRVSHLIEHLR CCCHHHHHHHHHHHH	16.09	-
344	Phosphorylation	IEHLRIHTQEKLYEC HHHHHHCCCCCHHHC	35.73	-
372	Phosphorylation	IHHQKIHTGEKPYEC CCCCCCCCCCCCCCC	50.97	-
384	Acetylation	YECRECGKAFCCSSH CCCCCCCCEEECCHH	50.37	7377539
400	Phosphorylation	TRHQRIHTMEKQYEC HHHHHHHHHHHHHHH	25.34	27251275
441	Phosphorylation	ECQKCRKSFNQLESL CHHHHHHHHHHHHHH	15.30	22496350
484	Phosphorylation	LQHHRIHTGEKPYEC HHCCCCCCCCCCEEE	44.67	28111955
489	Phosphorylation	IHTGEKPYECIKCGK CCCCCCCEEEEECCC	34.20	22817900
497	Phosphorylation	ECIKCGKTFSCSSNL EEEECCCEEECCCCC	13.18	24719451
512	Phosphorylation	TVHQRIHTGEKPYKC EEEEEEECCCCCEEC	44.67	29496963
517	Phosphorylation	IHTGEKPYKCNECGK EECCCCCEECCCCCC	38.96	18767875
518	Sumoylation	HTGEKPYKCNECGKA ECCCCCEECCCCCCC	38.83	-
518	Sumoylation	HTGEKPYKCNECGKA ECCCCCEECCCCCCC	38.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN181_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN181_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN181_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN181_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.