PCX2_HUMAN - dbPTM
PCX2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCX2_HUMAN
UniProt AC A6NKB5
Protein Name Pecanex-like protein 2
Gene Name PCNX2 {ECO:0000312|HGNC:HGNC:8736}
Organism Homo sapiens (Human).
Sequence Length 2137
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H)..
Protein Sequence MVSQVLQLLRQGVWAALTGGWYHDPEQSKFTNSCHLYLWLFLLLLPLALHLAFPPNAIIVFFYCSAVTIFFTIIKLVSYRLHLMFDKGEVIQQKPSRKEEKPNKDKEAKGEHITNHRNPSNNRQIHNGKKEEASRNLSTPPLRCSSRGQSITSHHSSGPLELSAQETVEDLKGVILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPVATETLINGKGKERGGKGQPPLRHRSEGGLVDKGPLKKLPHLSLSQYDLLETDVSFQPWGSENSVLIPEPVSCPRGSIRERVQSKSPQDSLSSSCPQCDTIVAKPVEEPADTSCQVDTSCQGDLPLHQEVDSSDSEVAVTLIDTSQPGDPLSLHEPIKIVITMSSTPNSMTDLESSLHLRVVGTEKTSVKSDAEPTNPGAAGSPNAEQISIPVITLDLPEGGGGGVPCPEGNGSERTPERLKTRVSTNQCSGYGSGEGGNAIKDHSSSSREPWESVSRLTPDTGSESKVGKEGQTNLDPSSCKSSHEKRHARVLSVDSGTDVFLSKSSAEIVNDTEKTMPTSKSDLEAKEGQMPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEILENEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSVLQVISGPETSVQEEISVDAMHVFIDEHGEIRSCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCSSTQGKFNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCRRASQEDMGLDDTASQQSVSDEQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
114PhosphorylationEAKGEHITNHRNPSN
CCCCCCCCCCCCCCC		27.21-
120PhosphorylationITNHRNPSNNRQIHN
CCCCCCCCCCCCCCC		50.73-
136N-linked_GlycosylationKKEEASRNLSTPPLR
CHHHHHHCCCCCCCC		35.53UniProtKB CARBOHYD
138PhosphorylationEEASRNLSTPPLRCS
HHHHHCCCCCCCCCC		42.28-
139PhosphorylationEASRNLSTPPLRCSS
HHHHCCCCCCCCCCC		31.90-
145PhosphorylationSTPPLRCSSRGQSIT
CCCCCCCCCCCCCCC		19.3529116813
146PhosphorylationTPPLRCSSRGQSITS
CCCCCCCCCCCCCCC		44.0229116813
189PhosphorylationIAPVSSTSPGIKVES
CCCCCCCCCCCEEEC		24.0724719451
254AcetylationLVDKGPLKKLPHLSL
CCCCCCHHCCCCCCC		56.2319818575
404PhosphorylationRVVGTEKTSVKSDAE
EEECCCCCCCCCCCC		32.30-
449N-linked_GlycosylationGVPCPEGNGSERTPE
CCCCCCCCCCCCCHH		49.51UniProtKB CARBOHYD
460PhosphorylationRTPERLKTRVSTNQC
CCHHHHHHCCCCCCC		40.6824144214
463PhosphorylationERLKTRVSTNQCSGY
HHHHHCCCCCCCCCC		20.5329116813
464PhosphorylationRLKTRVSTNQCSGYG
HHHHCCCCCCCCCCC		26.8429116813
468PhosphorylationRVSTNQCSGYGSGEG
CCCCCCCCCCCCCCC		25.8624144214
470PhosphorylationSTNQCSGYGSGEGGN
CCCCCCCCCCCCCCC		7.5729116813
472PhosphorylationNQCSGYGSGEGGNAI
CCCCCCCCCCCCCCC		25.7824144214
492PhosphorylationSSREPWESVSRLTPD
CCCCCCHHHHHHCCC		22.86-
542PhosphorylationSGTDVFLSKSSAEIV
CCCCEEECCCCCCCC		21.0122496350
550N-linked_GlycosylationKSSAEIVNDTEKTMP
CCCCCCCCCCCCCCC		57.03UniProtKB CARBOHYD
572N-linked_GlycosylationAKEGQMPNESNFLEF
HHCCCCCCCCCHHHH		61.05UniProtKB CARBOHYD
581PhosphorylationSNFLEFVSLLESINT
CCHHHHHHHHHHCCC		32.3429978859
585PhosphorylationEFVSLLESINTSKMT
HHHHHHHHCCCCCCC		22.5529978859
587N-linked_GlycosylationVSLLESINTSKMTAS
HHHHHHCCCCCCCCH		47.80UniProtKB CARBOHYD
588PhosphorylationSLLESINTSKMTASS
HHHHHCCCCCCCCHH		28.2329978859
589PhosphorylationLLESINTSKMTASSQ
HHHHCCCCCCCCHHH		18.8829978859
598N-linked_GlycosylationMTASSQLNGSAEQNE
CCCHHHCCCCHHHHH		34.43UniProtKB CARBOHYD
613N-linked_GlycosylationESGLLRDNCSQEKKE
HCCCCCCCCCHHHHH		22.39UniProtKB CARBOHYD
780PhosphorylationLLMVARRTQSETPRH
HHHHHHHCCCCCCCC		30.78-
782PhosphorylationMVARRTQSETPRHVS
HHHHHCCCCCCCCCC		42.71-
784PhosphorylationARRTQSETPRHVSQD
HHHCCCCCCCCCCCC		30.76-
798PhosphorylationDLEASSCSSTQGKFN
CCHHHCCCCCCCCCC		38.0721712546
799PhosphorylationLEASSCSSTQGKFNR
CHHHCCCCCCCCCCH		29.1321712546
882PhosphorylationLVMASCQYSLLKSVQ
HHHHHHHHHHHHHCC		12.9624719451
883PhosphorylationVMASCQYSLLKSVQP
HHHHHHHHHHHHCCC		11.0124719451
887PhosphorylationCQYSLLKSVQPDPAS
HHHHHHHHCCCCCCC		26.4226074081
894PhosphorylationSVQPDPASPIHGHNQ
HCCCCCCCCCCCCCC		29.7626074081
904PhosphorylationHGHNQIITYSRPIYF
CCCCCEECCCCHHHH		19.6426074081
905PhosphorylationGHNQIITYSRPIYFC
CCCCEECCCCHHHHH		7.7126074081
906PhosphorylationHNQIITYSRPIYFCV
CCCEECCCCHHHHHH		23.9526074081
991PhosphorylationDMLFFGGSAVSGITS
CCCCCCCCHHHHHHH		26.3517924679
994PhosphorylationFFGGSAVSGITSAVY
CCCCCHHHHHHHHHH		24.9717924679
1052PhosphorylationSYHLSRQSSDPSVLM
HHHHHCCCCCHHHHH		35.2827251275
1053PhosphorylationYHLSRQSSDPSVLMS
HHHHCCCCCHHHHHH		45.2427251275
1078PhosphorylationLHQNLAESAADPLPK
HHHHHHHHCCCCCCH		24.1319664994
1090PhosphorylationLPKKMKDSVTDVLKW
CCHHHCCHHHHHHHH		22.7728509920
1092PhosphorylationKKMKDSVTDVLKWDL
HHHCCHHHHHHHHHH		25.0928509920
1193PhosphorylationWLQCFEKYILYPALI
HHHHHHHHCHHHHHH		6.7520886841
1196PhosphorylationCFEKYILYPALILNA
HHHHHCHHHHHHHHH		4.1220886841
1278PhosphorylationFMVSILFSKLGDLLH
HHHHHHHHHHHHHHH		24.4324719451
1360PhosphorylationFWEKNYNTRRVDNSN
HHHHCCCCCCCCCCC		14.97-
1412N-linked_GlycosylationLVLGRWGNYSSGDCF
EECCCCCCCCCCCEE		26.93UniProtKB CARBOHYD
1496PhosphorylationAFHLRWLTWEITQTQ
HHHHHHHHHEEECHH		17.6927174698
1500PhosphorylationRWLTWEITQTQYILE
HHHHHEEECHHHHHH		17.6627174698
1502PhosphorylationLTWEITQTQYILEGY
HHHEEECHHHHHHCE		18.0627174698
1504PhosphorylationWEITQTQYILEGYSI
HEEECHHHHHHCEEE		15.7427174698
1509PhosphorylationTQYILEGYSILDNNA
HHHHHHCEEECCCCC		5.3327174698
1510PhosphorylationQYILEGYSILDNNAA
HHHHHCEEECCCCCC		27.7727174698
1518PhosphorylationILDNNAATMLQVFDL
ECCCCCCHHHHHHHH		18.9227174698
1539PhosphorylationYYIKSIIYYMVTSPK
HHHHHHHHHHHCCHH		5.4829083192
1540PhosphorylationYIKSIIYYMVTSPKL
HHHHHHHHHHCCHHH		3.7629083192
1543PhosphorylationSIIYYMVTSPKLLSW
HHHHHHHCCHHHHHH		23.8428111955
1544PhosphorylationIIYYMVTSPKLLSWI
HHHHHHCCHHHHHHH		14.5028111955
1549PhosphorylationVTSPKLLSWIKNESL
HCCHHHHHHHCCHHH		36.8728111955
1553N-linked_GlycosylationKLLSWIKNESLLKSL
HHHHHHCCHHHHHHC		34.65UniProtKB CARBOHYD
1555PhosphorylationLSWIKNESLLKSLQP
HHHHCCHHHHHHCHH		48.6924719451
1771PhosphorylationMLHRSFLSFKVIKVN
EEECCCCEEEEEEEC		22.4724719451
1805PhosphorylationNRNPERGSIQNNKQV
CCCCCCCCCCCHHHH		27.50-
1818N-linked_GlycosylationQVLRNLINSSCDQPL
HHHHHHHHCCCCCCC		30.91UniProtKB CARBOHYD
1937PhosphorylationTGRRKGRSQSVQAHS
CCCCCCCCHHHHHHH		35.1622210691
1939PhosphorylationRRKGRSQSVQAHSAL
CCCCCCHHHHHHHHH		19.9022210691
1947PhosphorylationVQAHSALSQRPPMLS
HHHHHHHHCCCCCCC		24.7022210691
1969PhosphorylationSRQTFLQTSTSVHEL
HHHHHHHHCCCHHHH		35.8028509920
1970PhosphorylationRQTFLQTSTSVHELA
HHHHHHHCCCHHHHH		13.0122496350
1972PhosphorylationTFLQTSTSVHELAQR
HHHHHCCCHHHHHHH		22.6528509920
1986PhosphorylationRLSGSRLSLHASATS
HHCCCCEEEEEECCC		19.59-
2054N-linked_GlycosylationLSAAEGGNTSDTQSS
CCCCCCCCCCCCCCC		47.46UniProtKB CARBOHYD
2109PhosphorylationLAEAVADTLGVVCRR
HHHHHHHHHHHHHHH		18.70-
2118PhosphorylationGVVCRRASQEDMGLD
HHHHHHHCCHHCCCC		32.08-
2127PhosphorylationEDMGLDDTASQQSVS
HHCCCCCCCCCCCCC		28.07-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCX2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCX2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCX2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PCX2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCX2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-991 AND SER-994, ANDMASS SPECTROMETRY.

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