dbPTM

RPC10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPC10_HUMAN
UniProt AC	Q9Y2Y1
Protein Name	DNA-directed RNA polymerase III subunit RPC10
Gene Name	POLR3K
Organism	Homo sapiens (Human).
Sequence Length	108
Subcellular Localization	Nucleus, nucleolus .
Protein Description	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)..
Protein Sequence	MLLFCPGCGNGLIVEEGQRCHRFSCNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWENVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	GQRCHRFSCNTCPYV CCEEEEEECCCCCCH	13.35	-
27	Phosphorylation	CHRFSCNTCPYVHNI EEEEECCCCCCHHHH	21.13	-
30	Phosphorylation	FSCNTCPYVHNITRK EECCCCCCHHHHHHH	19.25	-
35	Phosphorylation	CPYVHNITRKVTNRK CCCHHHHHHHHHCCC	29.74	-
71	Ubiquitination	STAESCPKCEHPRAY CCHHHCCCCCCCHHE	57.49	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RPC10_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPC10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPC10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RPAC1_HUMAN	POLR1C	physical	26344197
RPC4_HUMAN	POLR3D	physical	26344197

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPC10_HUMAN

Related Literatures of Post-Translational Modification