AT7L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT7L1_HUMAN
• UniProt AC: Q9ULK2
• Protein Name: Ataxin-7-like protein 1
• Gene Name: ATXN7L1
• Organism: Homo sapiens (Human).
• Sequence Length: 861
• Protein Sequence: MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNVDLEEAGKEGGKSREVMRLNKEDMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCERRHGSMCRPSPSPVSPASNPRTSLVQVKTKACLSGHHSASSTSKPFKTPKDNLLTSSSKQHTVFPAKGSRDKPCVPVPVVSLEKIPNLVKADGANVKMNSTTTTAVSASSTSSSAVSTPPLIKPVLMSKSVPPSPEKILNGKGILPTTIDKKHQNGTKNSNKPYRRLSEREFDPNKHCGVLDPETKKPCTRSLTCKTHSLSHRRAVPGRKKQFDLLLAEHKAKSREKEVKDKEHLLTSTREILPSQSGPAQDSLLGSSGSSGPEPKVASPAKSRPPNSVLPRPSSANSISSSTSSNHSGHTPEPPLPPVGGDLASRLSSDEGEMDGADESEKLDCQFSTHHPRPLAFCSFGSRLMGRGYYVFDRRWDRFRFALNSMVEKHLNSQMWKKIPPAADSPLPSPAAHITTPVPASVLQPFSNPSAVYLPSAPISSRLTSSYIMTSAMLSNAAFVTSPDPSALMSHTTAFPHVAATLSIMDSTFKAPSAVSPIPAVIPSPSHKPSKTKTSKSSKVKDLSTRSDESPSNKKRKPQSSTSSSSSSSSSSLQTSLSSPLSGPHKKNCVLNASSALNSYQAAPPYNSLSVHNSNNGVSPLSAKLEPSGRTSLPGGPADIVRQVGAVGGSSDSCPLSVPSLALHAGDLSLASHNAVSSLPLSFDKSEGKKRKNSSSSSKACKITKMPGMNSVHKKNPPSLLAPVPDPVNSTSSRQVGKNSSLALSQSSPSSISSPGHSRQNTNRTGRIRTLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	TLDRKVPSPEAFLGK CCCCCCCCHHHHCCC	38.06	25159151
48	Phosphorylation	AFLGKPWSSWIDAAK HHCCCCHHHHHHHHH	25.07	29083192
49	Phosphorylation	FLGKPWSSWIDAAKL HCCCCHHHHHHHHHH	24.96	29083192
74	Phosphorylation	AGKEGGKSREVMRLN HHHCCCCCHHHHCCC	36.63	23879269
124	Phosphorylation	HCERRHGSMCRPSPS HHHHHCCCCCCCCCC	14.48	23663014
129	Phosphorylation	HGSMCRPSPSPVSPA CCCCCCCCCCCCCCC	20.75	23663014
131	Phosphorylation	SMCRPSPSPVSPASN CCCCCCCCCCCCCCC	42.12	23663014
134	Phosphorylation	RPSPSPVSPASNPRT CCCCCCCCCCCCCCC	20.38	23663014
137	Phosphorylation	PSPVSPASNPRTSLV CCCCCCCCCCCCCEE	51.23	23663014
141	Phosphorylation	SPASNPRTSLVQVKT CCCCCCCCCEEEEEC	27.89	23312004
142	Phosphorylation	PASNPRTSLVQVKTK CCCCCCCCEEEEECC	28.02	23312004
148	Phosphorylation	TSLVQVKTKACLSGH CCEEEEECCHHHCCC	25.64	23312004
163	Acetylation	HSASSTSKPFKTPKD CCCCCCCCCCCCCCC	55.34	23954790
166	Acetylation	SSTSKPFKTPKDNLL CCCCCCCCCCCCCCC	72.88	26051181
178	Acetylation	NLLTSSSKQHTVFPA CCCCCCCCCCEEECC	48.31	26051181
186	Acetylation	QHTVFPAKGSRDKPC CCEEECCCCCCCCCC	58.62	26051181
191	Acetylation	PAKGSRDKPCVPVPV CCCCCCCCCCEEECE	38.93	26051181
247	Phosphorylation	LIKPVLMSKSVPPSP CCCCCCCCCCCCCCH	20.02	29255136
249	Phosphorylation	KPVLMSKSVPPSPEK CCCCCCCCCCCCHHH	32.33	30266825
253	Phosphorylation	MSKSVPPSPEKILNG CCCCCCCCHHHHHCC	39.35	30266825
281	Acetylation	NGTKNSNKPYRRLSE CCCCCCCCCCHHHHH	43.16	26051181
287	Phosphorylation	NKPYRRLSEREFDPN CCCCHHHHHCCCCCC	32.56	25159151
311	Phosphorylation	TKKPCTRSLTCKTHS CCCCCCCEEEEECCC	15.18	-
372	Phosphorylation	QSGPAQDSLLGSSGS CCCCCCHHHCCCCCC	17.26	22468782
380	Phosphorylation	LLGSSGSSGPEPKVA HCCCCCCCCCCCCCC	62.99	22468782
437	Phosphorylation	GDLASRLSSDEGEMD CCHHHHHCCCCCCCC	34.33	27732954
438	Phosphorylation	DLASRLSSDEGEMDG CHHHHHCCCCCCCCC	44.25	27732954
476	Methylation	FGSRLMGRGYYVFDR CCHHHHCCCEEEEEC	18.90	-
502	Phosphorylation	MVEKHLNSQMWKKIP HHHHHHHHHHHHHCC	27.98	25262027
602	Phosphorylation	DSTFKAPSAVSPIPA HCCCCCCCCCCCCCC	46.27	23312004
605	Phosphorylation	FKAPSAVSPIPAVIP CCCCCCCCCCCCCCC	19.48	25159151
613	Phosphorylation	PIPAVIPSPSHKPSK CCCCCCCCCCCCCCC	28.10	25159151
615	Phosphorylation	PAVIPSPSHKPSKTK CCCCCCCCCCCCCCC	48.78	21712546
619	Phosphorylation	PSPSHKPSKTKTSKS CCCCCCCCCCCCCCC	58.73	21712546
634	Phosphorylation	SKVKDLSTRSDESPS HHCCCCCCCCCCCCC	41.30	21712546
636	Phosphorylation	VKDLSTRSDESPSNK CCCCCCCCCCCCCCC	45.90	21712546
639	Phosphorylation	LSTRSDESPSNKKRK CCCCCCCCCCCCCCC	38.32	21712546
641	Phosphorylation	TRSDESPSNKKRKPQ CCCCCCCCCCCCCCC	71.24	-
649	Phosphorylation	NKKRKPQSSTSSSSS CCCCCCCCCCCCCCC	44.07	-
649	O-linked_Glycosylation	NKKRKPQSSTSSSSS CCCCCCCCCCCCCCC	44.07	30379171
650	Phosphorylation	KKRKPQSSTSSSSSS CCCCCCCCCCCCCCC	27.36	-
651	Phosphorylation	KRKPQSSTSSSSSSS CCCCCCCCCCCCCCC	37.56	-
654	Phosphorylation	PQSSTSSSSSSSSSS CCCCCCCCCCCCCCH	33.72	-
655	Phosphorylation	QSSTSSSSSSSSSSL CCCCCCCCCCCCCHH	35.87	-
656	Phosphorylation	SSTSSSSSSSSSSLQ CCCCCCCCCCCCHHH	35.87	-
657	Phosphorylation	STSSSSSSSSSSLQT CCCCCCCCCCCHHHH	35.87	-
720	Phosphorylation	KLEPSGRTSLPGGPA EECCCCCCCCCCCHH	37.83	25627689
721	Phosphorylation	LEPSGRTSLPGGPAD ECCCCCCCCCCCHHH	31.07	25627689
783	Phosphorylation	EGKKRKNSSSSSKAC CCCCCCCCCCCCCHH	34.33	25852190
784	Phosphorylation	GKKRKNSSSSSKACK CCCCCCCCCCCCHHH	43.57	25852190
785	Phosphorylation	KKRKNSSSSSKACKI CCCCCCCCCCCHHHH	38.15	25852190
786	Phosphorylation	KRKNSSSSSKACKIT CCCCCCCCCCHHHHC	37.49	25852190
787	Phosphorylation	RKNSSSSSKACKITK CCCCCCCCCHHHHCC	26.64	25852190
793	Phosphorylation	SSKACKITKMPGMNS CCCHHHHCCCCCCCC	13.54	-
829	Phosphorylation	SRQVGKNSSLALSQS CCCCCCCCCEEECCC	30.16	23312004
830	Phosphorylation	RQVGKNSSLALSQSS CCCCCCCCEEECCCC	27.36	27732954
834	Phosphorylation	KNSSLALSQSSPSSI CCCCEEECCCCCCCC	23.55	22199227
836	Phosphorylation	SSLALSQSSPSSISS CCEEECCCCCCCCCC	40.62	22199227
837	Phosphorylation	SLALSQSSPSSISSP CEEECCCCCCCCCCC	22.59	25849741
839	Phosphorylation	ALSQSSPSSISSPGH EECCCCCCCCCCCCC	42.10	22199227
840	Phosphorylation	LSQSSPSSISSPGHS ECCCCCCCCCCCCCC	29.85	27732954
842	Phosphorylation	QSSPSSISSPGHSRQ CCCCCCCCCCCCCCC	32.21	27732954
843	Phosphorylation	SSPSSISSPGHSRQN CCCCCCCCCCCCCCC	32.98	22199227
847	Phosphorylation	SISSPGHSRQNTNRT CCCCCCCCCCCCCCC	41.29	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT7L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT7L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT7L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR109_HUMAN	KRTAP10-9	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.